Calcium-Dependent Protein Kinases: Hubs in Plant Stress Signaling and Development

Schulz, Philipp; Herde, Marco; Romeis, Tina

doi:10.1104/pp.113.222539

Cited by 302 publications

(205 citation statements)

References 63 publications

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“…Although RLKs have been found to be important regulators of root hair growth in Arabidopsis under low-P conditions (Lan et al, 2013), their role seems to be much more general, as they also function in defense and stress responses, including drought, salinity, and cold (Lehti-Shiu et al, 2009;Ye et al, 2009;Das and Pandey, 2010;Marshall et al, 2012;Schulz et al, 2013;Vivek et al, 2013), possibly acting as hubs in stress signaling and development (Das and Pandey, 2010;Asano et al, 2012;Schulz et al, 2013). Several RLKs such as CRPK1 have been shown to play key roles in abiotic stress tolerance, positively or negatively regulating stress tolerance by modulating abscisic acid signaling and reducing the accumulation of reactive oxygen species (Lan et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Duplicate and Conquer: Multiple Homologs ofPHOSPHORUS-STARVATION TOLERANCE1Enhance Phosphorus Acquisition and Sorghum Performance on Low-Phosphorus Soils

et al. 2014

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Low soil phosphorus (P) availability is a major constraint for crop production in tropical regions. The rice (Oryza sativa) protein kinase, PHOSPHORUS-STARVATION TOLERANCE1 (OsPSTOL1), was previously shown to enhance P acquisition and grain yield in rice under P deficiency. We investigated the role of homologs of OsPSTOL1 in sorghum (Sorghum bicolor) performance under low P. Association mapping was undertaken in two sorghum association panels phenotyped for P uptake, root system morphology and architecture in hydroponics and grain yield and biomass accumulation under low-P conditions, in Brazil and/or in Mali. Root length and root surface area were positively correlated with grain yield under low P in the soil, emphasizing the importance of P acquisition efficiency in sorghum adaptation to low-P availability. SbPSTOL1 alleles reducing root diameter were associated with enhanced P uptake under low P in hydroponics, whereas Sb03g006765 and Sb03g0031680 alleles increasing root surface area also increased grain yield in a low-P soil. SbPSTOL1 genes colocalized with quantitative trait loci for traits underlying root morphology and dry weight accumulation under low P via linkage mapping. Consistent allelic effects for enhanced sorghum performance under low P between association panels, including enhanced grain yield under low P in the soil in Brazil, point toward a relatively stable role for Sb03g006765 across genetic backgrounds and environmental conditions. This study indicates that multiple SbPSTOL1 genes have a more general role in the root system, not only enhancing root morphology traits but also changing root system architecture, which leads to grain yield gain under low-P availability in the soil.

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Section: Discussionmentioning

confidence: 99%

Duplicate and Conquer: Multiple Homologs ofPHOSPHORUS-STARVATION TOLERANCE1Enhance Phosphorus Acquisition and Sorghum Performance on Low-Phosphorus Soils

et al. 2014

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“…This is in concert with earlier results. According to Schulz et al (2013), CDPKs have a major role in pollen tube growth. Twelve members of the Arabidopsis CDPK gene family are predominantly expressed in pollen (Myers et al 2009).…”

Section: Discussionmentioning

confidence: 99%

Genome-wide analysis and expression profiling of calcium-dependent protein kinases in potato (Solanum tuberosum)

et al. 2017

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“…Our previous proteomics analysis showed that NbCDPKiso2 was present in the affinity-purified fraction of RCNMV replication complex (29). CDPK is a calcium sensor protein and comprises a multigene family (e.g., 34 members in A. thaliana and 29 members in tomato), which is divided into four subgroups (38)(39)(40). Phylogenetic analysis revealed that NbCDPKiso2 belongs to subgroup II CDPK (Fig.…”

Section: Rcnmv Triggers An Intracellular Ros Burst Via the P27 Replicmentioning

confidence: 99%

Harnessing host ROS-generating machinery for the robust genome replication of a plant RNA virus

Hyodo

Hashimoto

Kuchitsu

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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As sessile organisms, plants have to accommodate to rapid changes in their surrounding environment. Reactive oxygen species (ROS) act as signaling molecules to transduce biotic and abiotic stimuli into plant stress adaptations. It is established that a respiratory burst oxidase homolog B of Nicotiana benthamiana (NbRBOHB) produces ROS in response to microbe-associated molecular patterns to inhibit pathogen infection. Plant viruses are also known as causative agents of ROS induction in infected plants; however, the function of ROS in plant-virus interactions remains obscure. Here, we show that the replication of red clover necrotic mosaic virus (RCNMV), a plant positive-strand RNA [(+)RNA] virus, requires NbRBOHB-mediated ROS production. The RCNMV replication protein p27 plays a pivotal role in this process, redirecting the subcellular localization of NbRBOHB and a subgroup II calcium-dependent protein kinase of N. benthamiana (NbCDPKiso2) from the plasma membrane to the p27-containing intracellular aggregate structures. p27 also induces an intracellular ROS burst in an RBOH-dependent manner. NbCDPKiso2 was shown to be an activator of the p27-triggered ROS accumulations and to be required for RCNMV replication. Importantly, this RBOH-derived ROS is essential for robust viral RNA replication. The need for RBOHderived ROS was demonstrated for the replication of another (+) RNA virus, brome mosaic virus, suggesting that this characteristic is true for plant (+)RNA viruses. Collectively, our findings revealed a hitherto unknown viral strategy whereby the host ROS-generating machinery is diverted for robust viral RNA replication.positive-strand RNA virus | viral RNA replication | reactive oxygen species | respiratory burst oxidase homolog | calcium-dependent protein kinase P lants have evolved complicated and sophisticated strategies to survive environmental changes. The rapid generation of reactive oxygen species (ROS) is one of the hallmarks of plant responses to various biotic and abiotic stresses (1). Plant NADPH oxidase, termed RBOHs (respiratory burst oxidase homologs), localize at the plasma membrane (PM) and intracellular compartments including the Golgi apparatus (2, 3) and play a key role in ROS production upon the perception of environmental stresses (4). In Nicotiana benthamiana, an RBOHB (NbRBOHB) plays important roles in ROS production triggered by microbe-associated molecular patterns (MAMPs), such as bacterial flagellin and fungal chitin, and facilitates plant immunity against biotrophic pathogens including an oomycete pathogen Phytophthola infestance and tobacco mosaic virus (5-8). RBOH activity is tightly and coordinately regulated posttranslationally [e.g., activation by Ca 2+ , phosphatidic acid (PA), G proteins, or protein kinases] (9-12). It has recently been shown that receptor-like cytoplasmic kinases and calciumdependent protein kinases (CDPKs) regulate RBOHs activity via direct phosphorylation or through modulating regulators of RBOHs during recognition of MAMPs via corresponding surface-loca...

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Calcium-Dependent Protein Kinases: Hubs in Plant Stress Signaling and Development

Abstract: These kinases are identified as integrators in plant signaling, with distinct as well as shared phosphorylation substrates mediating pathway specificity.

Cited by 302 publications

References 63 publications

Duplicate and Conquer: Multiple Homologs ofPHOSPHORUS-STARVATION TOLERANCE1Enhance Phosphorus Acquisition and Sorghum Performance on Low-Phosphorus Soils

Duplicate and Conquer: Multiple Homologs ofPHOSPHORUS-STARVATION TOLERANCE1Enhance Phosphorus Acquisition and Sorghum Performance on Low-Phosphorus Soils

Genome-wide analysis and expression profiling of calcium-dependent protein kinases in potato (Solanum tuberosum)

Harnessing host ROS-generating machinery for the robust genome replication of a plant RNA virus

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