Calcium export by sodium-calcium exchange in bovine chromaffin cells

Ca2+ clearance mechanisms in isolated rat adrenal chromaffin cells.

“…CCCP seems to raise the peak [Ca2+]i reached, even when Ca2+ entry is somewhat depressed (Figs 9F and lOC and E). These observations indicate that uptake into mitochondria can be fast enough to occur during the several-hundred millisecond depolarizations used here and this could interfere with the usual way of measuring endogenous fastacting cytoplasmic buffer strength (Neher & Augustine, 1992;Tse et al 1994 Na+-Ca2+ exchange is reported to be one of the major pathways for Ca2+ extrusion from bovine chromaffin cells (Powis, O'Brien & Von Grafenstein, 1991). In rat chromaffin cells, [Ca2+]i decay was moderately slowed by Na+ replacement (Fig.…”

Li+ in Bipolar Disorder – Possible Mechanisms of Its Pharmacological Mode of Action

“…This indicates that, under increased cellular excitability conditions, a new contribution to Li + influx appears which results from the activation of L-type voltagesensitive Ca 2+ channels. When the cells are depolarised, the intracellular Ca 2+ concentration largely increases, increasing the activity of the Na + /Ca 2+ exchanger, known to be a highcapacity, low-affinity mechanism of Ca 2+ efflux (Kao & Cheung, 1990;Powis et al, 1991). In our experiments, we propose that the Na + /Ca 2+ exchanger uses the external Na + and Li + to remove intracellular Ca 2+ accumulated during cell depolarisation.…”

Cytosolic organelles shape calcium signals and exo–endocytotic responses of chromaffin cells

“…In bovine chromaffin cells NCX1 can favour Na + -dependent Ca 2+ influx [143] or Ca 2+ export [144] and has been proposed to participate in the regulation of [Ca 2+ ] c and exocytosis in cat [150,161,162] and bovine chromaffin cells [142,143,153,[163][164][165]. In addition, chromaffin cells co-express NCX and the retinal rod-type K + -dependent Na + /Ca 2+ exchanger [166].…”

“…The Ca 2+ exit mode is referred to as the forward mode, and the Ca 2+ entry mode as the reverse mode of the NCX [141]. Bovine chromaffin cells express the major isoform of the NCX, namely NCX1 [142], which can mediate Na + -dependent Ca 2+ influx [143] or Ca 2+ export [144], depending on the circumstances.…”