2007
DOI: 10.1152/ajpcell.00120.2006
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Calcium-independent phospholipase A2-catalyzed plasmalogen hydrolysis in hypoxic human coronary artery endothelial cells

Abstract: Meyer MC, McHowat J. Calcium-independent phospholipase A2-catalyzed plasmalogen hydrolysis in hypoxic human coronary artery endothelial cells. Am J Physiol Cell Physiol 292: C251-C258, 2007. First published August 30, 2006; doi:10.1152/ajpcell.00120.2006.-Thrombin stimulation of human coronary artery endothelial cells (HCAEC) results in activation of a membrane-associated, calcium-independent phospholipase A2 (iPLA2) that selectively hydrolyzes membrane plasmalogen phospholipids. Rupture of an atherosclerotic … Show more

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Cited by 24 publications
(10 citation statements)
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“…However, expression of 5-LO in these cells resulted in ∼1.9-fold increase in cyst LT levels in response to hypoxia. The substrate, arachidonic acid, required for LT synthesis was likely formed due to hypoxia-mediated activation of phospholipase A 2 in endothelial cells as previously shown (40,41).…”
Section: Discussionmentioning
confidence: 63%
See 1 more Smart Citation
“…However, expression of 5-LO in these cells resulted in ∼1.9-fold increase in cyst LT levels in response to hypoxia. The substrate, arachidonic acid, required for LT synthesis was likely formed due to hypoxia-mediated activation of phospholipase A 2 in endothelial cells as previously shown (40,41).…”
Section: Discussionmentioning
confidence: 63%
“…3D), the same pharmacological inhibitors that inhibited hypoxia-induced FLAP mRNA expression. The substrate, arachidonic acid, for LT synthesis was likely formed endogenously in response to hypoxia, as hypoxia is known to activate phospholipase A 2 in endothelial cells (40,41).…”
Section: Hypoxia-mediated Lt Formation In Endothelial Cells Requires mentioning
confidence: 99%
“…Exposure of hypoxia as well as thrombin stimulation to endothelial cells induce the activation of membrane-associated calciumindependent phospholipase A 2 , which selectively hydrolyzes membrane Pls and preferentially PlsCho with arachidonic acid in sn -2 ( 32 ).…”
Section: Discussionmentioning
confidence: 99%
“…Studies have shown that microRNA-192 levels are high in tissues from type 1 and type 2 diabetic mice and also in diabetic kidney glomeruli (57,58). The locked nucleic acid-modified oligonucleotides, as microRNAinhibitors have been delivered successfully in mice (59), and locked nucleic acid-modified anti-microRNA-192 have been shown to specifically reduce microRNA-192 levels in mouse kidney and reduce diabetic nephropathy (58). Our studies demonstrate for the first time, to our knowledge, that posttranscriptional repression by microRNA-195a provides another avenue by which ET-1-mediated MIP-1b expression can be modulated.…”
Section: Discussionmentioning
confidence: 99%