Calcium isotope ratios in animal and human bone

Reynard, Linda M.; Henderson, Gideon M.; Hedges, R. E. M.

doi:10.1016/j.gca.2010.04.002

Cited by 83 publications

(91 citation statements)

References 71 publications

(126 reference statements)

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“…0 ¼ F diet − F bone þF resorp − F bile − F urine [5] and Eq. 6: 0 ¼ F diet δ diet − F bone ðδ soft þ ε bone Þ þ F resorp δ bone − F bile ðδ soft þ ε bile Þ − F urine ðδ soft þ ε urine Þ:…”

Section: Methodsunclassified

“…We estimated the fractionation factor of bone formation to be 7.5 ± 1 pptt (1 SD) and based the estimate on the offset between bone and diet in terrestrial vertebrates (4,5). This value seems to be similar among a phylogenetically wide range of vertebrates (4,5) and is unlikely to vary between individuals. ε 44/42 Ca urine .…”

Section: Datamentioning

confidence: 99%

“…First, in vertebrates, bone formation favors the lighter isotopes of Ca (4,5), thus depleting soft tissue of light Ca isotopes. Bone resorption releases this isotopically light Ca back into soft tissue with little or no isotope selectivity.…”

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confidence: 99%

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Rapidly assessing changes in bone mineral balance using natural stable calcium isotopes

Morgan

Skulan

Gordon

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

121

104

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The ability to rapidly detect changes in bone mineral balance (BMB) would be of great value in the early diagnosis and evaluation of therapies for metabolic bone diseases such as osteoporosis and some cancers. However, measurements of BMB are hampered by difficulties with using biochemical markers to quantify the relative rates of bone resorption and formation and the need to wait months to years for altered BMB to produce changes in bone mineral density large enough to resolve by X-ray densitometry. We show here that, in humans, the natural abundances of Ca isotopes in urine change rapidly in response to changes in BMB. In a bed rest experiment, use of high-precision isotope ratio MS allowed the onset of bone loss to be detected in Ca isotope data after about 1 wk, long before bone mineral density has changed enough to be detectable with densitometry. The physiological basis of the relationship between Ca isotopes and BMB is sufficiently understood to allow quantitative translation of changes in Ca isotope abundances to changes in bone mineral density using a simple model. The rate of change of bone mineral density inferred from Ca isotopes is consistent with the rate observed by densitometry in long-term bed rest studies. Ca isotopic analysis provides a powerful way to monitor bone loss, potentially making it possible to diagnose metabolic bone disease and track the impact of treatments more effectively than is currently possible.osteopenia | biomarker | medical geology | biosignature | spaceflight

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Section: Methodsunclassified

Section: Datamentioning

confidence: 99%

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Rapidly assessing changes in bone mineral balance using natural stable calcium isotopes

Morgan

Skulan

Gordon

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

121

104

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“…In former studies, the focus was on the possible influence of dairy product consumption on bone Ca isotope composition. Unfortunately, results did not allow animal milk intake to be distinguished from intrinsic biological variability (38)(39)(40).…”

Section: Significancementioning

confidence: 99%

Assessing human weaning practices with calcium isotopes in tooth enamel

Tacail

Thivichon-Prince

Martin

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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Weaning practices differ among great apes and likely diverged during the course of human evolution, but behavioral inference from the fossil record is hampered by a lack of unambiguous biomarkers. Here, we show that early-life dietary transitions are recorded in human deciduous tooth enamel as marked variations in Ca isotope ratios (δ 44/42 Ca). Using a sequential microsampling method along the enamel growth axis, we collected more than 150 enamel microsamples from 51 deciduous teeth of 12 different modern human individuals of known dietary histories, as well as nine enamel samples from permanent third molars. We measured and reconstructed the evolution of 44 Ca/ 42 Ca ratios in enamel from in utero development to first months of postnatal development. We show that the observed variations of δ 44/42 Ca record a transition from placental nutrition to an adult-like diet and that Ca isotopes reflect the duration of the breastfeeding period experienced by each infant. Typically, the δ 44/42 Ca values of individuals briefly or not breastfed show a systematic increase during the first 5-10 mo, whereas individuals with long breastfeeding histories display no measurable variation in δ 44/42 Ca of enamel formed during this time. The use of Ca isotope analysis in tooth enamel allows microsampling and offers an independent approach to tackle challenging questions related to past population dynamics and evolution of weaning practices in hominins.calcium isotopes | tooth enamel | dietary transitions | weaning | breast milk

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“…Calcium isotopes of human bone apatite may serve as useful archaeological source to reflect past human diet (mainly dairy or plant products), with an average fractionation of 0.65-0.75‰ relative to the diet (Chu et al 2006;Reynard et al 2010Reynard et al , 2011Reynard et al , 2013. Reynard et al (2011) concluded that in case of mixed dietary habits, milk consumption cannot be segregated out as the important source of calcium isotope ratios estimated from the bones.…”

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confidence: 99%

Role of stable isotope analyses in reconstructing past life-histories and the provenancing human skeletal remains: a review

Sehrawat

Kaur

2017

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This article reviews the present scenario of use of stable isotopes (mainly δ13C, δ 15 N, δ 18 O, 87 Sr) to trace past life behaviours like breast feeding and weaning practices, the geographic origin, migration history, paleodiet and subsistence patterns of past populations from the chemical signatures of isotopes imprinted in human skeletal remains. This approach is based on the state that food-web isotopic signatures are seen in the human bones and teeth and such signatures can change parallely with a variety of biogeochemical processes. By measuring δ 13 C and δ 15N isotopic values of subadult tissues of different ages, the level of breast milk ingestion at particular ages and the components of the complementary foods can be assessed. Strontium and oxygen isotopic analyses have been used for determining the geographic origins and reconstructing the way of life of past populations as these isotopes can map the isotopic outline of the area from where the person acquired water and food during initial lifetime. The isotopic values of strontium and oxygen values are considered specific to geographical areas and serve as reliable chemical signatures of migration history of past human populations (local or non-local to the site). Previous isotopic studies show that the subsistence patterns of the past human populations underwent extensive changes from nomadic to complete agricultural dependence strategies. The carbon and nitrogen isotopic values of local fauna of any archaeological site can be used to elucidate the prominence of freshwater resources in the diet of the past human populations found near the site. More extensive research covering isotopic descriptions of various prehistoric, historic and modern populations is needed to explore the role of stable isotope analysis for provenancing human skeletal remains and assessing human migration patterns/routes, geographic origins, paleodiet and subsistence practices of past populations.

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Calcium isotope ratios in animal and human bone

Cited by 83 publications

References 71 publications

Rapidly assessing changes in bone mineral balance using natural stable calcium isotopes

Rapidly assessing changes in bone mineral balance using natural stable calcium isotopes

Assessing human weaning practices with calcium isotopes in tooth enamel

Role of stable isotope analyses in reconstructing past life-histories and the provenancing human skeletal remains: a review

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