Calcium, magnesium, and zinc status in experimental hyperthyroidism

Abstract

In this study, experimental hyperthyroidism was established and used to investigate possible alterations in the calcium (Ca), magnesium (Mg), and zinc (Zn) homeostasis by assessing their concentrations in plasma and erythrocytes. In the L-thyroxine-induced hyperthyroidism condition, the experimental animals show a significant decrease in erythrocyte Ca, Mg, and Zn concentrations, and a significant decrease in plasma Mg concentration. Significant positive correlations were found for Mg and Zn both in plasma and in erythrocytes. The results suggest that the homeostasis of Ca, Mg, and Zn is altered during experimental hyperthyroidism.

Changes in the Serum Levels of Trace Elements Before and After the Operation in Thyroid Cancer Patients

“…Measurements conducted immediately after the operation also showed lower serum zinc and The differences between different superscripted letters in the same column are statistically significant (p < 0.05) Table 2 Pre-operative serum element levels of the cases Groups The differences between different superscripted letters in the same column are statistically significant (p < 0.05) Table 4 Post-operative serum element levels of the cases Groups selenium values than the control groups. There are several studies showing a correlation between zinc defect and thyroid hormone levels [16,19,20]. Zinc is an indispensable element in the functioning of 1,5′-deiodinase, which is necessary for the conversion of T 4 to T 3 [6].…”

“…In their study, Kralik and colleagues [13] established that selenium and zinc were important for the thyroid hormone metabolism and the deficiency of these elements would produce a negative impact on thyroid activity. Thyroid cancer patients were also reported to suffer from significantly lower levels of magnesium after the surgical operation [14,15] and experimental hyperthyroidism cases were shown to have lower magnesium levels than their controls both in the erythrocytes and plasma [16]. Altered thyroid activity was claimed to affect copper metabolism as well [2,17].…”

Metallothionein and the biology of aging

“…Third, in the Ames and Snell long-lived dwarf mice, multiple endocrine pathways are disrupted, and it is possible that MT expression is influenced by deficiencies in thyroid stimulating hormone (TSH) or prolactin (PRL) and their effects on zinc metabolism (Figure 4). For instance, hyperthyroidism in humans is associated with altered plasma and erythrocyte zinc concentration (Zhang et al, 2004), and in rats, experimental induction of hyperthyroidism by injection of L-thyroxine leads to decreased zinc erythrocyte concentrations (Simsek et al, 1997). Hyperprolactinemic patients have reduced plasma zinc levels and other studies support an inverse and mutual regulatory relationship between PRL and zinc concentration in plasma (Koppelman, 1988; Madureira et al, 1999).…”

L-thyroxine-induced hyperthyroidism affects elements and zinc in rats

“…In contrast, Simsek et al (9) found high erythrocyte zinc levels but could determine no change in plasma zinc levels in hyperthyroidism. The results reported by authors (8,9) cited above seem inconsistent with the studies arguing that the plasma zinc levels increased in hyperthyroidism (10,11). The studies exploring the relationship between hyperthyroidism and zinc show that the consensus has yet to be reached on this topic.…”

“…It was reported that although intra-erythrocyte zinc levels decreased by 54 % in rats with induced hyperthyroidism, there was no signifi cant change in plasma zinc levels (8). In contrast, Simsek et al (9) found high erythrocyte zinc levels but could determine no change in plasma zinc levels in hyperthyroidism. The results reported by authors (8,9) cited above seem inconsistent with the studies arguing that the plasma zinc levels increased in hyperthyroidism (10,11).…”