Calcium orthophosphate deposits: Preparation, properties and biomedical applications

Dorozhkin, Sergey V.

doi:10.1016/j.msec.2015.05.033

Cited by 262 publications

(165 citation statements)

References 937 publications

(1,055 reference statements)

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“…This ratio is significantly lower than that if stoichiometric HAP (1.67) and is on the order of what would be expected for ACP (although here, literature reports Ca/P ratios between 1.20 and 2.20) [59] or OCP. However, HAP is well known to form calcium-deficient apatite, and Ca/P ratios for these materials have been as low as 1.50 [59,60].…”

Section: Figurementioning

confidence: 99%

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Water-Soluble Cellulose Derivatives Are Sustainable Additives for Biomimetic Calcium Phosphate Mineralization

et al. 2016

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Abstract:The effect of cellulose-based polyelectrolytes on biomimetic calcium phosphate mineralization is described. Three cellulose derivatives, a polyanion, a polycation, and a polyzwitterion were used as additives. Scanning electron microscopy, X-ray diffraction, IR and Raman spectroscopy show that, depending on the composition of the starting solution, hydroxyapatite or brushite precipitates form. Infrared and Raman spectroscopy also show that significant amounts of nitrate ions are incorporated in the precipitates. Energy dispersive X-ray spectroscopy shows that the Ca/P ratio varies throughout the samples and resembles that of other bioinspired calcium phosphate hybrid materials. Elemental analysis shows that the carbon (i.e., polymer) contents reach 10% in some samples, clearly illustrating the formation of a true hybrid material. Overall, the data indicate that a higher polymer concentration in the reaction mixture favors the formation of polymer-enriched materials, while lower polymer concentrations or high precursor concentrations favor the formation of products that are closely related to the control samples precipitated in the absence of polymer. The results thus highlight the potential of (water-soluble) cellulose derivatives for the synthesis and design of bioinspired and bio-based hybrid materials.

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Section: Figurementioning

confidence: 99%

“…* Note that for ACP, the Ca/P ratios in the literature vary from ca. 1.20 to 2.20 [59,60]. Table 1 summarizes the results from elemental analysis.…”

Section: Figurementioning

confidence: 99%

Water-Soluble Cellulose Derivatives Are Sustainable Additives for Biomimetic Calcium Phosphate Mineralization

et al. 2016

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“…Calcium phosphate (CaP) compounds, such as hydroxyapatite (HA) which contains the main inorganic component of the bone, were adopted as coating material by many researchers. It was revealed that CaP/HA surface coating not only increases the biocompatibility but also provides a very tight implant-tissue bonding [34,35]. In addition, porous material is believed to have a reasonable and an adjustable modulus of elasticity [36].…”

Section: Introductionmentioning

confidence: 99%

A Review of Additive Mixed-Electric Discharge Machining: Current Status and Future Perspectives for Surface Modification of Biomedical Implants

Aliyu

Rani

Ginta

et al. 2017

Advances in Materials Science and Engineering

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Surface treatment remained a key solution to numerous problems of synthetic hard tissues. The basic methods of implant surface modification include various physical and chemical deposition techniques. However, most of these techniques have several drawbacks such as excessive cost and surface cracks and require very high sintering temperature. Additive mixed-electric discharge machining (AM-EDM) is an emerging technology which simultaneously acts as a machining and surface modification technique. Aside from the mere molds, dies, and tool fabrication, AM-EDM is materializing to finishing of automobiles and aerospace, nuclear, and biomedical components, through the concept of material migrations. The mechanism of material transfer by AM-EDM resembles electrophoretic deposition, whereby the additives in the AM-EDM dielectric fluids are melted and migrate to the machined surface, forming a mirror-like finishing characterized by extremely hard, nanostructured, and nanoporous layers. These layers promote the bone in-growth and strengthen the cell adhesion. Implant shaping and surface treatment through AM-EDM are becoming a key research focus in recent years. This paper reports and summarizes the current advancement of AM-EDM as a potential tool for orthopedic and dental implant fabrication. Towards the end of this paper, the current challenges and future research trends are highlighted.

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“…Therefore, CaPs are commonly used to coat orthopedic and dental implants [2][3][4]. CaP-based coatings, such as hydroxyapatite (HAP) and tricalcium phosphate (TCP), are known to have good bioactive ability and, consequently, to promote the regeneration of bones [5].…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Ceramics Consisting of Hydroxyapatite for Orthopaedic Implants

et al. 2017

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Abstract:This study aims to analyze hydroxyapatite (HAP) coatings enriched with Mg and Ti prepared by a magnetron sputtering technique on Ti6Al4V substrate. For preparation of the coatings, three magnetron targets (HAP, MgO and TiO 2 ) were simultaneously co-worked. The concentration of Mg added was varied by modifying the power applied to the MgO target. In all coatings, the Ti concentration was maintained constant by keeping the same cathode power fed during the whole deposition. The influence of different Mg dopant contents on the formation of phase, microstructure and morphology of the obtained Ti-doped HAP coatings were characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). Moreover, the effects of Mg addition upon corrosion, mechanical and biological properties were also investigated. Mg-and Ti-doped HAP coating obtained at low radio-frequency (RF) power fed to the MgO target provided material with high corrosion resistance compared to other coatings and bare alloy. A slight decrease in hardness of the coatings was found after the Mg addition, from 8.8 to 5.7 GPa. Also, the values of elastic modulus were decreased from 87 to 53 GPa, this being an advantage for biomedical applications. The coatings with low Mg concentration proved to have good deformation to yielding and higher plastic properties. Biological test results showed that the novel surfaces exhibited excellent properties for the adhesion and growth of bone cells. Moreover, early adherent vital cell numbers were significantly higher on both coatings compared to Ti6Al4V, suggesting that Mg ions may accelerate initial osteoblast adhesion and proliferation.

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Calcium orthophosphate deposits: Preparation, properties and biomedical applications

Cited by 262 publications

References 937 publications

Water-Soluble Cellulose Derivatives Are Sustainable Additives for Biomimetic Calcium Phosphate Mineralization

Water-Soluble Cellulose Derivatives Are Sustainable Additives for Biomimetic Calcium Phosphate Mineralization

A Review of Additive Mixed-Electric Discharge Machining: Current Status and Future Perspectives for Surface Modification of Biomedical Implants

Biodegradable Ceramics Consisting of Hydroxyapatite for Orthopaedic Implants

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