Calcium Phosphate Cement: Review of Mechanical and Biological Properties

Ambard, Alberto; Mueninghoff, Leonard A.

doi:10.1111/j.1532-849x.2006.00129.x

Cited by 342 publications

(262 citation statements)

References 46 publications

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“…Setting of calcium orthophosphate cements and concretes occurs mostly within the initial ~ 6 hours, yielding a ~ 80% conversion to the final products and a compressive strength of 40 -60 MPa. A hardening rate is strongly influenced by a powder to liquid ratio, as well as by addition of other chemicals [156,[514][515][516][517][518][519][520][521][522]. Despite a large number of formulations, all calcium orthophosphate cements can only form two different end products: CDHA and DCPD [156,515,516].…”

Section: Cements and Concretesmentioning

confidence: 99%

“…The need of bioceramics for minimal invasive surgery has induced the development of a concept of self-setting formulations consisting of only calcium orthophosphates to be applied as injectable and/or mouldable bone substitutes [156,400,401,418,475,[514][515][516][517][518][519][520][521][522]. In addition, there are reinforced formulations, which, in a certain sense, might be defined as calcium orthophosphate concretes [516].…”

Section: Cements and Concretesmentioning

confidence: 99%

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Medical Application of Calcium Orthophosphate Bioceramics

Dorozhkin¹

2011

BIO

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In the late 1960's, a strong interest was raised in biomedical applications of ceramic materials (named bioceramics a little bit later). Bioceramics was initially used as reasonable alternatives to metals in order to increase their biocompatibility. However, within a short period, it has grown into a diverse class of biomaterials, presently including three essential types: relatively bioinert, bioactive (or surface reactive) and bioresorbable bioceramics. This review is limited to bioceramics prepared from calcium orthophosphates only, which belong to the categories of bioactive and bioresorbable compounds. There have been a number of important advances in this field during the past 30 -40 years. The research was shifted from an initial study on the develop-ment of bioinert bioceramics towards bioactive and bioresorbable bioceramics, and these different types of calcium orthophosphate bioceramics can be tuned through the structural and compositional control. At the turn of the millennium, a new concept of calcium orthophosphate bioceramics has been developed to promote a regeneration of bones. Current biomedical applications of calcium orthophosphate bioceramics include artificial replacements for hips, knees, teeth, tendons and ligaments, as well as repair for periodontal disease, maxillofacial reconstruction, augmenttation and stabilization of the jawbone, spinal fusion and bone fillers after tumor surgery. Potential future applications of calcium orthophosphate bioceramics are demonstrated in drug delivery systems, effective carriers of growth factors, bioactive peptides and/or various types of cells for tissue engineering purposes.

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Section: Cements and Concretesmentioning

confidence: 99%

Section: Cements and Concretesmentioning

confidence: 99%

Medical Application of Calcium Orthophosphate Bioceramics

Dorozhkin¹

2011

BIO

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“…The advantages of CPC include a fast setting time, excellent moldability and good osteoconductivity (4,(6)(7)(8)(9). The early structural support that CPC offers is beneficial for large bone defects at risk of fracture.…”

Section: Discussionmentioning

confidence: 99%

“…There are various surgical treatment strategies for benign bone tumors, consisting of curettage, curettage with autologous/allogeneic bone grafting, and curettage with artificial bone grafting (3)(4)(5)(6)(7)(8). Calcium phosphate cement (CPC) is an injectable biocompatible bone substitute that has been used for various applications in orthopedic surgery, due to its easy handling, high mechanical strength and good osteoconductive biological properties (4,(6)(7)(8)(9). A previous study reported that CPC offered a useful bone substitute for the treatment of bone and soft tissue tumors; however, the follow-up time was short (median follow-up, 18.5 months) (6).…”

Section: Introductionmentioning

confidence: 99%

Treatment of bone defect with calcium phosphate cement subsequent to tumor curettage in pediatric patients

et al. 2015

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Abstract. The aim of the present study was to investigate the mid-to long-term clinical performance of calcium phosphate cement (CPC) in the treatment of benign bone tumors in pediatric patients with a follow-up of at least 2-years. The cases of 33 patients with benign bone tumors treated by curettage and subsequent implantation of CPC were retrospectively reviewed. The patients consisted of 13 males and 20 females, with a median age of 13 years and median follow-up time of 79 months. All patients were alive at the time of review. No toxicity was detected in routine blood tests. Radiography was used to confirm that CPC was well adapted to the surrounding host bone, although the resorbability of CPC was not obtained for all patients at the final follow-up. Local tumor recurrence occurred in 4 patients. None of the patients reported post-operative fractures. In total, 6 patients required a second surgical procedure, as follows: 4 patients in whom local tumor recurrence occurred; 1 patient with post-operative superficial wound infection, who underwent wound debridement; and 1 patient that required the removal of CPC due to deep infection at the proximal humerus. All patients had regained full physical function without any pain at the final follow-up. The present study recommends that the properties of CPC should be taken into consideration and applied to the reconstruction of bone defects subsequent to curettage of bone tumors.

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INTRODUÇÃOOs cimentos de fosfato de cálcio são utilizados cada vez mais como biomateriais por se ligarem química e biologicamente com o tecido ósseo adjacente com posterior reabsorção [1]. Suas aplicações vão desde reconstrução de partes de tecidos ósseos traumatizados [2,3] a formulações que apresentam ações antimicrobianas [4,5].

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