Treatment of bone defect with calcium phosphate cement subsequent to tumor curettage in pediatric patients

Abstract

Abstract. The aim of the present study was to investigate the mid-to long-term clinical performance of calcium phosphate cement (CPC) in the treatment of benign bone tumors in pediatric patients with a follow-up of at least 2-years. The cases of 33 patients with benign bone tumors treated by curettage and subsequent implantation of CPC were retrospectively reviewed. The patients consisted of 13 males and 20 females, with a median age of 13 years and median follow-up time of 79 months. All patients were alive at the time of review. No toxicity was detected in routine blood tests. Radiography was used to confirm that CPC was well adapted to the surrounding host bone, although the resorbability of CPC was not obtained for all patients at the final follow-up. Local tumor recurrence occurred in 4 patients. None of the patients reported post-operative fractures. In total, 6 patients required a second surgical procedure, as follows: 4 patients in whom local tumor recurrence occurred; 1 patient with post-operative superficial wound infection, who underwent wound debridement; and 1 patient that required the removal of CPC due to deep infection at the proximal humerus. All patients had regained full physical function without any pain at the final follow-up. The present study recommends that the properties of CPC should be taken into consideration and applied to the reconstruction of bone defects subsequent to curettage of bone tumors.

Bone grafts and biomaterials substitutes for bone defect repair: A review

“…Phase separation, which means the separation of powder and liquid components during injection, is another important concern associated with the clinical applications of CPCs [136] . By distracting other crucial properties of CPCs, several methods have achieved clinical success in some applications after the abundant studies over the past two decades [137] , [138] , [139] , [140] , [141] . However, recent research tended to gain the relationship of those critical parameters of CPCs by theoretical calculations and analysis [142] , [143] , [144] , [145] , [146] , [147] , [148] , due to the extremely difficult optimization by sole experimental work.…”

Critical review: Injectability of calcium phosphate pastes and cements

“…This ability of CPC has shown great potential in percutaneous surgery whereby CPC is injected into the body to fill bone defects and stabilise fractures. Although CPC has shown clinical success in several orthopaedic applications requiring delivery by injection [6][7][8][9][10][11][12], it is thought that several issues currently prevent routine application in clinical applications. This has given rise to a high volume of studies…”

Mid‐ to long‐term clinical outcome of giant cell tumor of bone treated with calcium phosphate cement following thorough curettage and phenolization

“…CPC is a bone void filler used in orthopaedic surgery (trauma and spine and craniofacial surgery . Furthermore, CPC is also used for filling the cavity after curettage of various types of bone tumors . If a radiolucent area is observed after insufficient filling of the cavity with CPC, the area gradually reduces with time due to bone formation around the CPC …”