Calcium phosphate cements: action of setting regulators on the properties of the β-tricalcium phosphate-monocalcium phosphate cements

Mirtchi, A A; Lemaître, Jean-Pierre; Munting, Everard

doi:10.1016/0142-9612(89)90120-8

Cited by 129 publications

(69 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…One is a cement based on calcium phosphate materials, such as ␤-TCP. [15][16][17][18] This type is resorbable and is mainly used as a bone substitute because it is not strong enough for use under weight-bearing conditions. The second type is a cement made by mixing a bioactive filler, such as HA powder, with resin.…”

Section: Discussionmentioning

confidence: 99%

Transmission electron microscopic study of interface between bioactive bone cement and bone: Comparison of apatite and wollastonite containing glass-ceramic filler with hydroxyapatite and ?-tricalcium phosphate fillers

Okada

Kobayashi

Fujita

et al. 1999

J. Biomed. Mater. Res.

View full text Add to dashboard Cite

We developed a bioactive bone cement that consists of apatite and wollastonite containing glass-ceramic (AW-GC) powder and bisphenol-a-glycidyl methacrylate (Bis-GMA) based resin. In this study, we made three types of cement (designated AWC, HAC, and TCPC) consisting of either AW-GC, hydroxyapatite (HA), or beta-tricalcium phosphate (beta-TCP) powder as the inorganic filler and Bis-GMA based resin as the organic matrix. These cements were implanted into rat tibiae and cured in situ. Specimens were prepared 1, 2, 4, and 8 weeks after the operation and observed using transmission electron microscopy. Each of the bone cements was in direct contact with the bone. In AWC-implanted tibiae, the uncured surface layer of Bis-GMA based resin was completely filled with newly formed bone-like tissue 2 weeks after implantation. The AW-GC particles were surrounded by bone and were in contact with bone through an apatite layer. No intervening soft tissue was seen. In HAC-implanted tibiae, it took 4 weeks for the uncured layer to completely fill with newly formed bonelike tissue. The HA particles were also in contact with bone through an apatite layer. In TCPC-implanted tibiae, it took 8 weeks for the uncured layer to fill with newly formed bone-like tissue. The new bone that formed on the TCPC was not as dense as that on the AWC or HAC, and an intervening apatite layer was not evident. Results indicated that AWC had higher bioactivity than either HAC or TCPC.

show abstract

Section: Discussionmentioning

confidence: 99%

Transmission electron microscopic study of interface between bioactive bone cement and bone: Comparison of apatite and wollastonite containing glass-ceramic filler with hydroxyapatite and ?-tricalcium phosphate fillers

Okada

Kobayashi

Fujita

et al. 1999

J. Biomed. Mater. Res.

View full text Add to dashboard Cite

show abstract

“…One is based on calcium phosphate materials, such as ␤-tricalcium phosphate. [16][17][18][19] This type is resorbable and is used mainly as a bone substitute because it is not strong enough for use under loadbearing conditions. The second type is made by mixing a bioactive filler, such as hydroxyapatite powder, with resin.…”

Section: Discussionmentioning

confidence: 99%

Repair of segmental bone defects using bioactive bone cement: Comparison with PMMA bone cement

Okada

Kawanabe

Fujita

et al. 1999

J. Biomed. Mater. Res.

View full text Add to dashboard Cite

We developed a bioactive bone cement (BABC) that consists of apatite and wollastonite containing glass ceramic (AW-GC) powder and bisphenol-A-glycidyl dimethacrylate (Bis-GMA) based resin. In the present study, the effectiveness of the BABC for repair of segmental bone defects under load-bearing conditions was examined using a rabbit tibia model. Polymethylmethacrylate (PMMA) bone cement was used as a control. A 15-mm length of bone was resected from the middle of the shaft of the tibia, and the tibia was fixed by two Kirschner wires. The defects were replaced by cement. Each cement was used in 12 rabbits; six rabbits were sacrificed at 12 and 25 weeks after surgery, and the tibia containing the bone cement was excised and tension tested. At both the intervals studied, the failure loads of the BABC were significantly higher than those of the PMMA cement. The BABC was in direct contact with bone, whereas soft tissue was observed between the cement and bone in all PMMA cement specimens. Results indicated that the BABC was useful as a bone substitute under load-bearing conditions.

show abstract

“…Calcium phosphate cements precipitating brushite have been developed by Lemam( tre et al for more than 10 yr [5,6]. -Tricalcium phosphate ( -TCP) and monocalcium phosphate monohydrate powders are mixed with water and dissolution}precipitation phenomenon * Correspondence address: Departments of Orthopaedics and Bioengineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0412, USA.…”

Section: Introductionmentioning

confidence: 99%

The effects of calcium phosphate cement particles on osteoblast functions

et al. 2000

View full text Add to dashboard Cite

Calcium phosphate cements (CPC) are increasingly used in the orthopedic "eld. This kind of cement has potential applications in bone defect replacements, osteosynthetic screw reinforcements or drug delivery. In vivo studies have demonstrated a good osteointegration of CPC. However, it was also observed that the resorption of CPC could create particles. It is known from orthopedic implant studies that particles can be responsible for the peri-implant osteolysis. Biocompatibility assessment of CPC should then be performed with particles. In this study, we quanti"ed the functions of osteoblasts in the presence of -TCP, brushite and cement particles. Two particle sizes were prepared. The "rst one corresponded to the critical diameter range 1}10 m and the second one had a diameter larger than 10 m. We found that CPC particles could adversely a!ect the osteoblast functions. A decrease in viability, proliferation and production of extracellular matrix was measured. A dose e!ect was also observed. A ratio of 50 CPC particles per osteoblast could be considered as the maximum number of particles supported by an osteoblast. The smaller particles had stronger negative e!ects on osteoblast functions than the larger ones. Future CPC development should minimize the generation of particles smaller than 10 m.

show abstract

Calcium phosphate cements: action of setting regulators on the properties of the β-tricalcium phosphate-monocalcium phosphate cements

Cited by 129 publications

References 3 publications

Transmission electron microscopic study of interface between bioactive bone cement and bone: Comparison of apatite and wollastonite containing glass-ceramic filler with hydroxyapatite and ?-tricalcium phosphate fillers

Transmission electron microscopic study of interface between bioactive bone cement and bone: Comparison of apatite and wollastonite containing glass-ceramic filler with hydroxyapatite and ?-tricalcium phosphate fillers

Repair of segmental bone defects using bioactive bone cement: Comparison with PMMA bone cement

The effects of calcium phosphate cement particles on osteoblast functions

Contact Info

Product

Resources

About