Calcium phosphate cements: effect of fluorides on the setting and hardening of β-tricalcium phosphate-dicalcium phosphate-calcite cements

Mirtchi, A A; Lemaître, Jean-Pierre; Munting, Everard

doi:10.1016/0142-9612(91)90150-9

Cited by 37 publications

(15 citation statements)

References 9 publications

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“…However, it has not been observed in enamel, dentin or bone. In biomedicine, β-TCP is used in calcium orthophosphate bone cements [144,145,146,147]. In combination with HA, β-TCP forms a biphasic calcium phosphate (BCP [148]) [151,152,153,154,155,156,157,158,159,160].…”

Section: The Members Of the Calcium Orthophosphate Familymentioning

confidence: 99%

“…The need of biomaterials for minimal invasive surgery has induced the development of a concept of self-setting bone cements made from calcium orthophosphates to be applied as injectable and/or mouldable bone substitutes [78,84,85,86,87,93,94,95,96,106,107,108,109,110,144,145,146,147,170,171,338,654,655,668,685,686,687,688,689]. This is a low temperature bioceramics.…”

Section: Calcium Orthophosphates As Biomaterials and Bioceramicsmentioning

confidence: 99%

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Calcium Orthophosphates in Nature, Biology and Medicine

Dorozhkin¹

2009

Materials

692

550

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The present overview is intended to point the readers’ attention to the important subject of calcium orthophosphates. These materials are of the special significance because they represent the inorganic part of major normal (bones, teeth and dear antlers) and pathological (i.e. those appearing due to various diseases) calcified tissues of mammals. Due to a great chemical similarity with the biological calcified tissues, many calcium orthophosphates possess remarkable biocompatibility and bioactivity. Materials scientists use this property extensively to construct artificial bone grafts that are either entirely made of or only surface-coated with the biologically relevant calcium ortho-phosphates. For example, self-setting hydraulic cements made of calcium orthophosphates are helpful in bone repair, while titanium substitutes covered by a surface layer of calcium orthophosphates are used for hip joint endoprostheses and as tooth substitutes. Porous scaffolds made of calcium orthophosphates are very promising tools for tissue engineering applications. In addition, technical grade calcium orthophosphates are very popular mineral fertilizers. Thus ere calcium orthophosphates are of great significance for humankind and, in this paper, an overview on the current knowledge on this subject is provided.

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Section: The Members Of the Calcium Orthophosphate Familymentioning

confidence: 99%

Section: Calcium Orthophosphates As Biomaterials and Bioceramicsmentioning

confidence: 99%

Calcium Orthophosphates in Nature, Biology and Medicine

Dorozhkin¹

2009

Materials

692

550

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“…[36][37][38][39][40] However, cement type calcium phosphate material in paste form processes self-setting property in situ, thereby solving these technical problems. [41][42][43][44] The characteristic properties of the self setting materials work to prevent intervention for undesirable connective tissues or dispersion of the calcium phosphate particles in to the surrounding tissue.…”

Section: Discussionmentioning

confidence: 99%

An experimental study of use of absorbable plate in combination with self-setting α-tricalcium phosphate for orthognathic surgery

Okabe

Ueki

Marukawa

et al. 2010

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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An experimental study of use of absorbable plate in combination with self-setting α-tricalcium phosphate for orthognathic surgery Abstract Purpose: The purpose of this study was to histologically and immuno-histochemically evaluate bone formation using both of self-setting α-tricalcium phosphate (α-TCP; BIOPEX ® ) and absorbable plate (Super FIXSORB ® -MX) in rabbit cranium bone.Study design: Adult male Japanese white rabbits (n=16, 12-16 weeks, 2.5-3.0 kg) were used. The surgical defects were made in the nasal bone of a rabbit and BIOPEX ® was implanted in the left side and no material in the right side. Two-hall-absorbable plate and two screws (Super FIXSORB ® -MX) were fixed across the defect in each side. The rabbits were sacrificed at1, 4, 12 and 24 weeks postoperatively, and formalin-fixed specimens were embedded in acrylic resin. The specimens were stained with hematoxylin and eosin. For immune-histochemical analysis, the specimens were treated with bone morphogenetic protein-2 (BMP-2) antibodies. Finally, these were evaluated microscopically.Results: New bone formation was observed in the region of absorbable plate and nasal membrane after more than 4 weeks. The area of BIOPEX ® ＋new bone was significantly 3 larger than that of control side after 1, 4 and 12 weeks (P<0.05). The number of BMP-2 stained cell in experimental side was significantly larger than that in control side after 4 and 12 weeks (P<0.05). Conclusion

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“…On mixing in aqueous media the reaction leads to the formation of acicular apatite crystals which resulted in hardening. Several modifications of t he original formula have been propos ed [110,111 ] and some of them include fluoride ions as a soluble salt (NaF, ge nerally) [112][113]. Fluoride ions favour the formation of apatite crystals and accelerate the hydrolysis reaction of the calcium salts originally present in the cement paste.…”

Section: Fluoridated Cementsmentioning

confidence: 99%