Calcium phosphate cements: study of the β-tricalcium phosphate — dicalcium phosphate — calcite cements

Mirtchi, A A; Lemaître, Jean-Pierre; Munting, Everard

doi:10.1016/0142-9612(90)90121-6

Cited by 89 publications

(34 citation statements)

References 6 publications

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“…Reports on calcium phosphate cement are available in the literature and different formulations can be seen [1][2][3][4][5][6][7][8][9][10][11]. The authors developed a system based on Monma's report [14,15], in which an cx-TCP/DCPD mixture was mixed with water containing sodium succinate, for control of the setting time of 8-10 min, and sodium chondroitine sulphate, for smooth mixing.…”

Section: Discussionmentioning

confidence: 99%

Calcium phosphate cement: in vitro and in vivo studies of the α-tricalcium phosphate-dicalcium phosphate dibasic-tetracalcium phosphate monoxide system

Kurashina

Kitamura

Hirano

et al. 1995

J Mater Sci: Mater Med

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In this paper, calcium phosphate cement consisting of ~-tricalcium phosphate (a-TCP), dicalcium phosphate dibasic (DCPD) and tetracalcium phosphate monoxide (TeCP) was investigated in vitro and in vivo. Measurements of compressive strength against soaking time in simulated body fluid (SBF) showed a rapid increase of the hardness for the first 7 days. The gained strength was retained up to 1 year and the maximal mean value was 94.7 (_+ 14.4)MPa. X-ray diffraction (XRD) and scanning electron microscopy (SEM) presented precipitates of hydroxyapatite (HA) after mixing, also after soaking in SBF and after implantation in rat subcutaneous tissues. However, the conversion to HA happened in different ways between in vitro and in vivo exposures. Histologic examinations showed that the cement causes the same reactions at the interface with surrounding soft tissues as HA. The authors consider the cement to be a promising material as a bone substitute, bone cement or dental material, however, further studies in a paste form and in bone tissue environments are necessary.

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Section: Discussionmentioning

confidence: 99%

Calcium phosphate cement: in vitro and in vivo studies of the α-tricalcium phosphate-dicalcium phosphate dibasic-tetracalcium phosphate monoxide system

Kurashina

Kitamura

Hirano

et al. 1995

J Mater Sci: Mater Med

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“…The concept of biphasic ceramics has however sparsely been developed in view of controlling the resorption of ionic cements [25][26][27][28][29]. Calcium carbonate compounds have a higher solubility than apatite [30][31] and although some mineral cements containing calcium carbonate have already been proposed, the use of very large proportions of calcium carbonate (≥ 20% w/w in the dry powder ingredients) opens new possibilities which have not yet been explored [4,26,[32][33].…”

Section: Introductionmentioning

confidence: 99%

Calcium carbonate–calcium phosphate mixed cement compositions for bone reconstruction

Combes

Bareille

Rey

2006

J Biomedical Materials Res

116

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The feasibility of making calcium carbonate-calcium phosphate (CaCO 3 -CaP) mixed cements, comprising at least 40 % (w/w) CaCO 3 in the dry powder ingredients, has been demonstrated.Several original cement compositions were obtained by mixing metastable crystalline calcium carbonate phases with metastable amorphous or crystalline calcium phosphate powders in aqueous medium. The cements set within at most 1 hour at 37°C in atmosphere saturated with water. The hardened cement is microporous and exhibits weak compressive strength. The setting reaction appeared to be essentially related to the formation of a highly carbonated nanocrystalline apatite phase by reaction of the mestastable CaP phase with part or almost all of the metastable CaCO 3 phase. The recrystallization of metastable CaP varieties led to a final cement consisting of a highly carbonated poorly crystalline apatite (PCA) analogous to bone mineral associated with various amounts of vaterite and/or aragonite. The presence of controlled amounts of CaCO 3 with a higher solubility than the apatite formed in the welldeveloped calcium phosphate cements might be of interest to increase resorption rates in biomedical cement and favor its replacement by bone tissue. Cytotoxicity testing revealed excellent cytocompatibility of CaCO 3 -CaP mixed cement compositions.

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“…[29][30][31] α-TCP is predominant during bone resorption in the early stage of bone healing; [32][33][34][35] this may lead to technically difficulties in both the filling of particles to fit the bone defects and their delivery to form the desired shape. [36][37][38][39][40] However, cement type calcium phosphate material in paste form processes self-setting property in situ, thereby solving these technical problems. [41][42][43][44] The characteristic properties of the self setting materials work to prevent intervention for undesirable connective tissues or dispersion of the calcium phosphate particles in to the surrounding tissue.…”

Section: Discussionmentioning

confidence: 99%

An experimental study of use of absorbable plate in combination with self-setting α-tricalcium phosphate for orthognathic surgery

Okabe

Ueki

Marukawa

et al. 2010

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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An experimental study of use of absorbable plate in combination with self-setting α-tricalcium phosphate for orthognathic surgery Abstract Purpose: The purpose of this study was to histologically and immuno-histochemically evaluate bone formation using both of self-setting α-tricalcium phosphate (α-TCP; BIOPEX ® ) and absorbable plate (Super FIXSORB ® -MX) in rabbit cranium bone.Study design: Adult male Japanese white rabbits (n=16, 12-16 weeks, 2.5-3.0 kg) were used. The surgical defects were made in the nasal bone of a rabbit and BIOPEX ® was implanted in the left side and no material in the right side. Two-hall-absorbable plate and two screws (Super FIXSORB ® -MX) were fixed across the defect in each side. The rabbits were sacrificed at1, 4, 12 and 24 weeks postoperatively, and formalin-fixed specimens were embedded in acrylic resin. The specimens were stained with hematoxylin and eosin. For immune-histochemical analysis, the specimens were treated with bone morphogenetic protein-2 (BMP-2) antibodies. Finally, these were evaluated microscopically.Results: New bone formation was observed in the region of absorbable plate and nasal membrane after more than 4 weeks. The area of BIOPEX ® ＋new bone was significantly 3 larger than that of control side after 1, 4 and 12 weeks (P<0.05). The number of BMP-2 stained cell in experimental side was significantly larger than that in control side after 4 and 12 weeks (P<0.05). Conclusion

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Calcium phosphate cements: study of the β-tricalcium phosphate — dicalcium phosphate — calcite cements

Cited by 89 publications

References 6 publications

Calcium phosphate cement: in vitro and in vivo studies of the α-tricalcium phosphate-dicalcium phosphate dibasic-tetracalcium phosphate monoxide system

Calcium phosphate cement: in vitro and in vivo studies of the α-tricalcium phosphate-dicalcium phosphate dibasic-tetracalcium phosphate monoxide system

Calcium carbonate–calcium phosphate mixed cement compositions for bone reconstruction

An experimental study of use of absorbable plate in combination with self-setting α-tricalcium phosphate for orthognathic surgery

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