Calcium, Phosphorus, and Vitamin D in Dogs and Cats

Stockman, J.A.; Villaverde, Cecilia; Corbee, Ronald Jan

doi:10.1016/j.cvsm.2021.01.003

Cited by 18 publications

(31 citation statements)

References 54 publications

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“…The 25(OH)VD metabolite has been shown to be the best indicator of whole-body VD status in veterinary patients. 64,65 This form of VD has a long half-life (2-3 weeks) and serves as a reservoir for generation of the biologically active form. 66,67 Serum samples for CRP were sent to Texas A&M University Gastrointestinal Laboratory for the measurement of CRP using an enzyme-linked immunosorbent assay S1, for details on clinical scoring.…”

Section: Biomarker Analysismentioning

confidence: 99%

Serum 25‐hydroxyvitamin D and C‐reactive protein and plasma von Willebrand concentrations in 23 dogs with chronic hepatopathies

Ambrosini

Piedra-Mora

Jennings

et al. 2022

Veterinary Internal Medicne

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Background: Serum concentrations of 25-hydroxyvitamin D (25(OH)VD) and C-reactive protein (CRP) and von Willebrand's factor (vWF) concentration correlate with histopathologic disease grade and stage in chronic inflammatory and fibrotic hepatopathies (CH) in humans. Objectives: To evaluate serum 25(OH)VD and serum CRP concentrations and plasma vWF concentration and determine if they correlate with histopathologic and biochemical variables in dog with CH. Animals: Twenty-three client-owned dogs with a histopathologic diagnosis of CH were prospectively enrolled.Methods: Blood samples were collected before liver biopsy. Correlations between biomarkers and clinical pathological and histopathologic variables were evaluated using Pearson's or Spearman's test.Results: Serum 25(OH)VD concentration (median, 213 nmol/L; range, 42-527 nmol/L) was negatively correlated with serum aspartate aminotransferase activity (AST; rho = À0.59, P < .01), polymorphonuclear neutrophil count (PMN; r = À0.46, P < .05), and positively correlated with serum albumin concentration (r = 0.69, P < .001). Serum CRP concentration (median, 7.4 μg/L; range, 1-44.9 μg/L) was positively correlated with overall histopathologic necroinflammatory activity (r = 0.78, P < .001) and fibrosis score (rho = 0.49, P < .05). Plasma vWF concentration (median, 73.3%; range, 15-141%) was Abbreviations: 25(OH)VD, 25-hydroxyvitamin D; ALP, alkaline phosphatase; ALT, alanine aminotransferase; aPTT, activated partial thromboplastin time; AST, aspartate aminotransferase; CH, chronic hepatopathies; CRP, C-reactive protein; H&E, hematoxylin and eosin; PMN, polymorphonuclear neutrophil; PT, prothrombin time; vWF, von Willebrand's factor; WBC, white blood cell.

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Section: Biomarker Analysismentioning

confidence: 99%

Serum 25‐hydroxyvitamin D and C‐reactive protein and plasma von Willebrand concentrations in 23 dogs with chronic hepatopathies

Ambrosini

Piedra-Mora

Jennings

et al. 2022

Veterinary Internal Medicne

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“…It requires sequential hydroxylations in the liver and kidney to reach its physiologically active form (calcitriol or 1,25-dihydroxyvitamin D3). It is a steroidal hormone known to regulate calcium and phosphorus homeostasis in the body, as well as bone metabolism, among other properties [25,26]. The blood level of vitamin D is positively correlated with good musculoskeletal health and negatively correlated with OA or mobility reduction [25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

“…It is a steroidal hormone known to regulate calcium and phosphorus homeostasis in the body, as well as bone metabolism, among other properties [25,26]. The blood level of vitamin D is positively correlated with good musculoskeletal health and negatively correlated with OA or mobility reduction [25][26][27][28][29]. It has been shown in some studies that vitamin D supplementation can help patients with OA [25,30,31].…”

Section: Introductionmentioning

confidence: 99%

Adding Krill Oil and Low Molecular Weight Hyaluronic Acid to Movoflex® Soft Chews Helps Improve Dogs’ Mobility

CS¹,

Schreiber²,

CA³

et al. 2022

GJMR

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Movoflex® Soft Chew (Virbac, USA) is a nutritional supplement to support dogs’ mobility. It contains a unique combination of five ingredients: eggshell membrane, hyaluronic acid (HA) of high molecular weight, Boswellia serrata extract, astaxanthin, and vitamin D3. Krill oil and low molecular weight HA are now added to the supplement. The tolerance of this advanced formula was first evaluated in dogs. The aspect, palatability of the chew, and effectiveness on mobility criteria were then assessed by sixty-nine dog owners who were regular users of the current Movoflex® Soft Chews. The chew was found to be well-tolerated and similar in terms of aspect and acceptability to the current one. All but one mobility criteria significantly improved after 30 days, including the ability to walk, climb, stand, interact with people, or the way of walking.

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“…However, studies have established that high levels of dietary Ca for puppies and growing dogs can result in adverse growth and health effects, with certain breeds and dog size categories being most susceptible [ 3 , 4 , 5 , 6 ]. Cofactors such as health status [ 7 , 8 ] or synergistic or inhibitory interactions of Ca with other minerals [ 9 , 10 , 11 , 12 , 13 ], particularly P and vitamins [ 14 , 15 ], are also thought to be influential in modifying its potential effect on health.…”

Section: Introductionmentioning

confidence: 99%

No Observed Adverse Effects on Health Were Detected in Adult Beagle Dogs When Fed a High-Calcium Diet for 40 Weeks

Atwal¹,

Stockman²,

Gilham³

et al. 2021

Animals

Self Cite

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The implications of long-term high calcium (Ca) intake are well documented in growing dogs and in adult dogs of large breed size, however, the consequences on other breeds and breed sizes are yet to be determined. Eighteen neutered adult beagles, nine males and nine females aged 1.4–4.4 years, were randomized to control or test diets providing in g∙4184 kJ−1 (1000 kcal−1): 1.44 and 7.19 total Ca balanced with 1.05 and 4.25 total phosphorus, respectively, for 40 weeks. Health parameters, ultrasound scans, radiographs, glomerular filtration rate, and mineral balance were measured at eight-week intervals. All dogs remained healthy with no measured evidence of orthopedic, urinary, or renal disease. The test diet resulted in a 5.2 fold increase in fecal Ca excretion. Apparent Ca digestibility (%) and Ca balance (g/d) did not significantly (p > 0.05) change from baseline in the test diet group, although dogs displayed a positive Ca balance (maximum at week 8, 1.11 g/d with 95% CI (0.41, 1.80)) before a neutral Ca balance was restored at week 32. Despite an initial positive Ca balance, we can conclude that no measurable adverse health effects were observed as a result of the test diet fed in this study in beagles over a period of 40 weeks.

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Calcium, Phosphorus, and Vitamin D in Dogs and Cats

Cited by 18 publications

References 54 publications

Serum 25‐hydroxyvitamin D and C‐reactive protein and plasma von Willebrand concentrations in 23 dogs with chronic hepatopathies

Serum 25‐hydroxyvitamin D and C‐reactive protein and plasma von Willebrand concentrations in 23 dogs with chronic hepatopathies

Adding Krill Oil and Low Molecular Weight Hyaluronic Acid to Movoflex® Soft Chews Helps Improve Dogs’ Mobility

No Observed Adverse Effects on Health Were Detected in Adult Beagle Dogs When Fed a High-Calcium Diet for 40 Weeks

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