Calcium Signaling Derangement and Disease Development and Progression

Sivaraman, Vijay; Onyenwoke, Rob U.

doi:10.3390/biology10040291

Cited by 3 publications

(2 citation statements)

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“…Ca 2+ dysregulation is involved in the manifestation of several pulmonary diseases [48]. Because of this fact, an understanding of Ca 2+ signaling mechanisms and the role that Ca 2+ signaling plays in disease pathology is important.…”

Section: Discussionmentioning

confidence: 99%

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Calcium-Dependent Pulmonary Inflammation and Pharmacological Interventions and Mediators

Onyenwoke

Sivaraman

2021

Biology

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Pulmonary diseases present a significant burden worldwide and lead to severe morbidity and mortality. Lung inflammation caused by interactions with either viruses, bacteria or fungi is a prominent characteristic of many pulmonary diseases. Tobacco smoke and E-cig use (“vaping”) are considered major risk factors in the development of pulmonary disease as well as worsening disease prognosis. However, at present, relatively little is known about the mechanistic actions by which smoking and vaping may worsen the disease. One theory suggests that long-term vaping leads to Ca2+ signaling dysregulation. Ca2+ is an important secondary messenger in signal transduction. Cellular Ca2+ concentrations are mediated by a complex series of pumps, channels, transporters and exchangers that are responsible for triggering various intracellular processes such as cell death, proliferation and secretion. In this review, we provide a detailed understating of the complex series of components that mediate Ca2+ signaling and how their dysfunction may result in pulmonary disease. Furthermore, we summarize the recent literature investigating the negative effects of smoking and vaping on pulmonary disease, cell toxicity and Ca2+ signaling. Finally, we summarize Ca2+-mediated pharmacological interventions that could potentially lead to novel treatments for pulmonary diseases.

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Section: Discussionmentioning

confidence: 99%

“…Ca 2+ dysregulation is an attributable trait that was described for various diseases including pulmonary diseases such as asthma and ALI [48]. However, little is known about the mechanistic action of Ca 2+ dysregulation in these diseases.…”

Section: Additional Ca 2+ Signaling Componentsmentioning

confidence: 99%