Calcium supplementation on bone loss in postmenopausal women

Shea, Beverley; Wells, George A.; Cranney, Ann; Zytaruk, Nicole; Griffith, Lauren; Hamel, Candyce; Ortiz, Zulma; Peterson, Joan; Tugwell, Peter; Welch, Vivian

doi:10.1002/14651858.cd004526.pub2

Cited by 93 publications

(52 citation statements)

References 28 publications

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“…Studies were excluded if participants had undergone bariatric surgery or were taking medications designed to induce weight loss. Studies were also excluded if the intervention involved calcium supplementation or supervised exercise, or if exercise was the primary means of eliciting weight loss, because of potential confounding effects of calcium supplementation (35,56) or physical activity on bone mass. (57) Because physical activity is frequently recommended for weight management, to reduce publication bias we included interventions in which exercise was recommended as part of a healthier lifestyle, provided that the exercise was not supervised or was not the primary focus of the intervention.…”

Section: Methodsmentioning

confidence: 99%

Does Diet-Induced Weight Loss Lead to Bone Loss in Overweight or Obese Adults? A Systematic Review and Meta-Analysis of Clinical Trials

Zibellini

Seimon

Lee

et al. 2015

Journal of Bone and Mineral Research

116

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Diet-induced weight loss has been suggested to be harmful to bone health. We conducted a systematic review and meta-analysis (using a random-effects model) to quantify the effect of diet-induced weight loss on bone. We included 41 publications involving overweight or obese but otherwise healthy adults who followed a dietary weight-loss intervention. The primary outcomes examined were changes from baseline in total hip, lumbar spine, and total body bone mineral density (BMD), as assessed by dual-energy X-ray absorptiometry (DXA). Secondary outcomes were markers of bone turnover. Diet-induced weight loss was associated with significant decreases of 0.010 to 0.015 g/cm 2 in total hip BMD for interventions of 6, 12, or 24 (but not 3) months' duration (95% confidence intervals [CIs], -0.014 to -0.005, -0.021 to -0.008, and -0.024 to -0.000 g/cm 2 , at 6, 12, and 24 months, respectively). There was, however, no statistically significant effect of diet-induced weight loss on lumbar spine or whole-body BMD for interventions of 3 to 24 months' duration, except for a significant decrease in total body BMD (-0.011 g/cm 2 ; 95% CI, -0.018 to -0.003 g/cm 2 ) after 6 months. Although no statistically significant changes occurred in serum concentrations of N-terminal propeptide of type I procollagen (P1NP), interventions of 2 or 3 months in duration (but not of 6, 12, or 24 months' duration) induced significant increases in serum concentrations of osteocalcin (0.26 nmol/L; 95% CI, 0.13 to 0.39 nmol/L), C-terminal telopeptide of type I collagen (CTX) (4.72 nmol/L; 95% CI, 2.12 to 7.30 nmol/L) or N-terminal telopeptide of type I collagen (NTX) (3.70 nmol/L; 95% CI, 0.90 to 6.50 nmol/L bone collagen equivalents [BCEs]), indicating an early effect of diet-induced weight loss to promote bone breakdown. These data show that in overweight and obese individuals, a single diet-induced weight-loss intervention induces a small decrease in total hip BMD, but not lumbar spine BMD. This decrease is small in comparison to known metabolic benefits of losing excess weight.

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Section: Methodsmentioning

confidence: 99%

Does Diet-Induced Weight Loss Lead to Bone Loss in Overweight or Obese Adults? A Systematic Review and Meta-Analysis of Clinical Trials

Zibellini

Seimon

Lee

et al. 2015

Journal of Bone and Mineral Research

116

View full text Add to dashboard Cite

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“…Regarding the effects of diet, the balanced ingestion of calcium (8,9)/vitamin D (10)/vitamin K (11) is recommended by the "Japanese 2015 Guidelines for Prevention and Treatment of Osteoporosis" (1), and several studies have reported that it increases BMD, thereby preventing fractures (12)(13)(14). In the intervention performed in the present study, a leaflet was delivered to visually promote understanding, and guidance through detailed explanations was conducted.…”

Section: Discussionmentioning

confidence: 99%

Ability of community pharmacists to promote self-care and self-medication by local residents [I]: Improvements in bone mineral density

Wada

Ennyu

et al. 2017

DD&T

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“…Увеличение экскреции кальция в суточной моче при лечении препаратом Кальций-Д 3 Никомед форте, указы-вающее на повышение объема всасывания кальция в ЖКТ [17], и нормализация уровня ПТГ свидетельствуют об устранении кальциевого дефицита при лечении препара-тами Кальций-Д 3 Никомед и Кальций-Д 3 Никомед форте. По данным многих авторов, назначение комбинированной терапии кальцием и витамином D приводит к снижению уровня биохимических маркеров костной резорбции [3,15].…”

Section: Discussionunclassified

EFFEKTIVNOST' PRIMENENIYaKOMBINIROVANNOY TERAPII KAL'TsIEMS VYSOKIMI I SREDNIMI DOZAMI VITAMINA D3dlya profilaktiki postmenopauzal'nogo osteoporoza

Древаль¹,

MARChENKOVA²,

Kryukova³

et al. 2007

Osteopor Bone Dis

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Проведено исследование эффективности средних (400 МЕ/сут.) и высоких (800 МЕ/сут.) дозировок витамина D в сочетании с кальцием (1000 мг/сут.) для профилактики остеопороза у женщин в постменопаузе с остеопеническим синдромом. В исследование включили 30 женщин в возрасте 45-70 лет с остеопенией L 2 -L 4 , из которых были сфор-мированы 3 исследуемые группы по 10 человек: 1 -группа лечения препаратом Кальций-Д 3 Никомед форте, 2 -груп-па лечения препаратом Кальций-Д 3 Никомед и 3 -группа сравнения.На фоне терапии препаратом Кальций-Д 3 Никомед форте повысилась МПК в позвоночнике (p<0,05) и трохантере (p<0,01), а при лечении препаратом Кальций-Д 3 Никомед показатели МПК во всех отделах скелета практически не изменились. В то же время в группе сравнения отмечалась достоверная потеря МПК в позвоночнике (p<0,05), области Варда (p<0,05), трохантере (p<0,05) и проксимальном отделе бедра в целом (p<0,001). На фоне терапии обоими препара-тами нормализовался исходно повышенный уровень ПТГ, хотя изменений уровня кальциемии при этом не отмечалось. Одновременно в группе сравнения снизились уровень общего кальция сыворотки крови (p<0,05) и экскреция кальция в суточной моче, увеличилась концентрация неорганического фосфора (p<0,05), и, как следствие, повысился уровень ПТГ (p<0,05). Также в группах лечения наблюдались достоверное уменьшение активности щелочной фосфатазы (p<0,05) и стабильные показатели остеокальцина, в то время как в группе сравнения уровни этих показателей существенно возросли (p<0,05 через 6 месяцев и p<0,05 через 12 месяцев).Таким образом, результаты исследования продемонстрировали высокую эффективность средних и высоких дози-ровок витамина D в сочетании с кальцием при профилактике постменопаузального остеопороза, однако высокие дозы витамина D оказывают более существенный эффект на МПК.

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Calcium supplementation on bone loss in postmenopausal women

Abstract: Calcium supplementation alone has a small positive effect on bone density. The data show a trend toward reduction in vertebral fractures, but it is unclear if calcium reduces the incidence of non vertebral fractures.

Cited by 93 publications

References 28 publications

Does Diet-Induced Weight Loss Lead to Bone Loss in Overweight or Obese Adults? A Systematic Review and Meta-Analysis of Clinical Trials

Does Diet-Induced Weight Loss Lead to Bone Loss in Overweight or Obese Adults? A Systematic Review and Meta-Analysis of Clinical Trials

Ability of community pharmacists to promote self-care and self-medication by local residents [I]: Improvements in bone mineral density

EFFEKTIVNOST' PRIMENENIYaKOMBINIROVANNOY TERAPII KAL'TsIEMS VYSOKIMI I SREDNIMI DOZAMI VITAMINA D3dlya profilaktiki postmenopauzal'nogo osteoporoza

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