Calcium Transport and Signaling in Mitochondria

Bravo-Sagua, Roberto; Parra, Valentina; López-Crisosto, Camila; Díaz, Paula; Quest, Andrew F. G.; Lavandero, Sergio

doi:10.1002/cphy.c160013

Cited by 215 publications

(156 citation statements)

References 101 publications

Supporting

Mentioning

156

Contrasting

Order By: Relevance

“…In other cell types, mitochondria are known to act as Ca 2+ i stores, in addition to the ER, and play an important role in maintenance of Ca 2+ i homoeostasis (Rizzuto, De Stefani, Raffaello, & Mammucari, 2012). Specifically, increased OxPhos activity likely triggers mitochondrial Ca 2+ uptake through the mitochondrial Ca 2+ uniporter (mCu), resulting in increased Ca 2+ mt stores, which have been shown to increase mitochondrial oxidative function and ATP production (Bravo-Sagua et al, 2017). Investigation of Ca 2+ mt uptake in sperm is limited, but considerable evidence suggests maintenance of Ca 2+ mt homoeostasis is essential for motility regulation in human (Bravo et al, 2015) and bovine sperm (Rodriguez, Satorre, & Beconi, 2012).…”

Section: Alci Um and S Perm Motilit Ymentioning

confidence: 99%

Sperm mitochondrial regulation in motility and fertility in horses

Meyers

Bulkeley

Foutouhi

2019

Reprod Domestic Animals

View full text Add to dashboard Cite

The biological nature of age‐related declines in fertility in males of any species, including stallions, has been elusive. In horses, the economic costs to the breeding industry are frequently extensive. Mitochondrial function in ejaculated sperm, which is essential for sperm motility, is reflected by adenosine triphosphate production, mitochondrial oxidative efficiency and production of reactive oxygen species, and that this balance may become compromised in ageing stallions and during the process of cryopreservation. This presentation will focus on mitochondrial integrity and function as an avenue for understanding the pathophysiology of sperm when undergoing cryopreservation and male ageing. We discuss the importance of understanding the differences and similarities of sperm mitochondria to that of somatic cells regarding structure and mitochondrial biochemistry relating to sperm function. The roles of oxidative phosphorylation and glycolysis in sperm mitochondria are outlined as is the method of determining oxygen consumption and calcium homoeostasis in sperm mitochondria. Further, we outline the role of oxidative stress and reactive oxygen species.

show abstract

Section: Alci Um and S Perm Motilit Ymentioning

confidence: 99%

Sperm mitochondrial regulation in motility and fertility in horses

Meyers

Bulkeley

Foutouhi

2019

Reprod Domestic Animals

View full text Add to dashboard Cite

show abstract

“…These include atherosclerosis, 10–14 ischaemia‐reperfusion, 11,15–19,94 infection/sepsis, 20–37 and various autoimmune diseases 38–50 . Due to the direct link between mitochondrial stress and intracellular calcium dyshomeostasis, 84–86 the effect of intracellular calcium on CpG‐ODN‐mediated innate immune signalling is relevant to the study of these disease states associated with sterile inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…Exposing WEHI‐2312 B lymphoma cells to CpG‐ODN results in degradation of both IκBα and IκBβ, 83 but whether this occurs in non‐cancerous cells is unknown. While it is well known that mitochondrial stress can disrupt intracellular calcium homeostasis, 84–86 how this affects CpG‐ODN TLR9‐NFκB signalling is unknown.…”

Section: Introductionmentioning

confidence: 99%

CpG‐ODN‐mediated TLR9 innate immune signalling and calcium dyshomeostasis converge on the NFκB inhibitory protein IκBβ to drive IL1α and IL1β expression

et al. 2020

View full text Add to dashboard Cite

Sterile inflammation contributes to many pathological states associated with mitochondrial injury. Mitochondrial injury disrupts calcium homeostasis and results in the release of CpG-rich mitochondrial DNA. The role of CpG-stimulated TLR9 innate immune signalling and sterile inflammation is well studied; however, how calcium dyshomeostasis affects this signalling is unknown. Therefore, we interrogated the relationship besween intracellular calcium and CpG-induced TLR9 signalling in murine macrophages. We found that CpG-ODN-induced NFjB-dependent IL1a and IL1b expression was significantly attenuated by both calcium chelation and calcineurin inhibition, a finding mediated by inhibition of degradation of the NFjB inhibitory protein IjBb. In contrast, calcium ionophore exposure increased CpG-induced IjBb degradation and IL1a and IL1b expression. These results demonstrate that through its effect on IjBb degradation, increased intracellular Ca 2+ drives a pro-inflammatory TLR9-mediated innate immune response. These results have implications for the study of innate immune signalling downstream of mitochondrial stress and injury.

show abstract

“…The prime example of this is the effects of calcium on mitochondrial function: mitochondria can rapidly take up calcium, which stimulates their function, but too much induces mitochondrial permeability transition and death [72]. The stress can come in many forms, ranging from compounds that inhibit cellular function, to hypoxia, to starvation, radiation and critically, physical activity.…”

Section: What Hormesis Tells Us; Order From Chaosmentioning

confidence: 99%

The Hormesis of Thinking: A Deeper Quantum Thermodynamic Perspective?

Nunn¹,

Guy²,

Bell³

2017

Int J Neurorehabilitation Eng

View full text Add to dashboard Cite

We are able to read this because of quantum and thermodynamic principles that via an inorganic proton gradient, possibly generated 4.2 billion years ago, gave rise to a system that has an awareness of time and space by using energy to integrate information. Life can be described as a dissipative system driven by an energy gradient that uses information to positively reinforce its self-sustaining structure, which in turn increases its non-linear decisional capacity. Key in the evolution of life has been stress coupled to natural selection, which usually meant an increased demand for energy. As hormesis describes the adaptive response to stress, we propose that hormesis embraces not only the evolution of life, but that of intelligence itself, as natural selection would favour systems that enhances its efficiency. A component of the hormetic response in eukaryotes is the mitochondrion, which itself relies on quantum effects such as tunnelling. This suggests that quantum effects control the stability of individual cells as well as long-lived cellular networks. Hormesis, which can be anti-inflammatory, is therefore key in maintaining the functional stability of complex systems, including the brain. In contrast, a lack of classical hormetic factors, such as physical activity, plant polyphenols, or calorie restriction, will lead to accelerated cognitive decline, which is associated with increased inflammation. However, there may be another previously unidentified factor that could also be considered hormetic, and that is thinking itself. Here we propose that the process of "thinking", and managing complex movement, induces "stress" in the neuronal system and is therefore in itself part of maintaining cognitive health and reserve throughout life. In effect, the right amount of thinking and information processing can beneficially induce adaptation, and this itself could be explainable by quantum thermodynamics.

show abstract

Calcium Transport and Signaling in Mitochondria

Cited by 215 publications

References 101 publications

Sperm mitochondrial regulation in motility and fertility in horses

Sperm mitochondrial regulation in motility and fertility in horses

CpG‐ODN‐mediated TLR9 innate immune signalling and calcium dyshomeostasis converge on the NFκB inhibitory protein IκBβ to drive IL1α and IL1β expression

The Hormesis of Thinking: A Deeper Quantum Thermodynamic Perspective?

Contact Info

Product

Resources

About