Calcium transport by isolated brush border and basolateral membrane vesicles: Role of essential fatty acid supplementation

Effects of arachidonic acid and docosahexaenoic acid on differentiation and mineralization of MC3T3‐E1 osteoblast‐like cells

“…Polyunsaturated fatty acids (PUFAs) have been implicated in bone homeostasis both in vitro [1][2][3] and in vivo. [4][5][6][7][8] There is increasing evidence that lack of certain PUFAs in the diet can induce bone loss, [9][10][11] while dietary supplementation of some PUFAs has been shown to be beneficial for bone.…”

“…2 Some suggested mechanisms of action for the PUFAs in these models include the following: modulation of calcium absorption from the intestine, increased bone mineralization, enhancement of bone collagen synthesis, and reduction of urinary calcium excretion, thereby increasing the pool of available calcium for bone mineralization in the body. 1,4,5,12,13 Others have shown that acidic phospholipids facilitate cartilage mineralization in the growth plate, 15 while prostaglandins, which are synthesized from fatty acids, affect insulin-like growth factors and bone formation in animals. 16,17 The effects of PUFAs at the cellular level are not fully understood.…”

n-3 Fatty acids and cardiovascular disease: Actions and molecular mechanisms

“…Molecular mechanisms by which n-3 FA act on CVD while still not fully defined, include a spectrum of events varying from altering membrane fluidity [57] and receptor responses following their incorporation into cell membranes to direct binding to intracellular receptors regulating gene transcription [58,59]. Many of these effects are depicted in Figure 1.…”

Inhibition of Osteoporosis Due to Restricted Food Intake by the Fish Oils DHA and EPA and Perilla Oil in the Rat

“…The fish oils DHA and EPA and P oil appeared to inhibit Ca excretion. EPA supplementation is reported to increase Ca absorption 10,11) and decrease Ca excretion. [12][13][14][15] Therefore, the fish oils DHA and EPA and perilla oil appear to inhibit osteoporosis due to restricted food intake to decrease Ca excretion.…”

“…8) PGE 2 has also been demonstrated to enhance PTH-stimulated bone resorption. 9) Linoleic acid, EPA, and gamma linolenic acid supplementation are reported to increase Ca absorption, 10,11) and decrease calcium excretion. [12][13][14][15] Hence inhibition of osteoporosis due to restricted food intake by SB oil rich in linoleic acid, P oil with much alpha linolenic acid, and the fish oils EPA and DHA was investigated in this study.…”