Calciuria in symptom-free primigravid women remote from term: Is the response to an oral calcium challenge predictable?

Suarez, Victor R.; Miyahira, Juan; Guinn, Debra A.; Fisher, Susan G.; Tomich, Paul G.; Trelles, Juan

doi:10.1016/s0002-9378(99)70028-1

Cited by 6 publications

(4 citation statements)

References 6 publications

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“…Maternal circulating levels of ICTP and PICP were measured in stored serial plasma samples (À70jC) obtained previously at 16,20,24,28,32 and 36 weeks from nine women who developed pre-eclampsia and 17 normal pregnant controls. All the women were white Europeans and part of a larger study to investigate peripheral vascular function using non-invasive methods.…”

Section: Subjectsmentioning

confidence: 99%

A longitudinal study of biochemical markers of bone turnover during normal pregnancy and pregnancies complicated by pre-eclampsia

Anim-Nyame¹

2002

BJOG: An International Journal of Obstetrics and Gynaecology

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Objectives To test the hypothesis that the increased bone turnover observed in established pre-eclampsia is present earlier in pregnancy prior to the diagnosis of pre-eclampsia. Design A prospective longitudinal study.Setting Obstetric Unit at Chelsea and Westminster Hospital, London.Population Nine women who subsequently developed pre-eclampsia and 17 normal pregnant controls.Methods Maternal plasma levels of the cross-linked carboxyl terminal telopeptide of the type I collagen (ICTP), a marker of bone resorption, and of the carboxy-terminal propeptide of type I collagen (PICP), a marker of bone formation, were measured longitudinally in nine women who developed pre-eclampsia and 17 women with normal pregnancy. Serial blood samples were obtained at 16, 20, 24, 28, 32 and 36 weeks of gestation and the levels of ICTP and PICP were measured by radio-immunoassay. Results ICTP and PICP increased progressively in the normal pregnant and pre-eclampsia groups, but the rate of increase was significantly greater in the latter ( P ¼ 0.00002 and 0.0008, unpaired t test, for ICTP and PICP summary measures, respectively). In the pre-eclampsia group, positive correlation were observed between ICTP levels at 36 weeks of gestation and plasma uric acid (r ¼ 0.9, P ¼ 0.001) and degree of proteinuria (r ¼ 0.78, P ¼ 0.04). No correlation was observed between the two bone markers and other variables during normal pregnant group. Conclusion These data show that biochemical markers of bone turnover are greater in pregnancies complicated by pre-eclampsia compared with normal pregnancy but only when the disease is clinically evident.

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Section: Subjectsmentioning

confidence: 99%

A longitudinal study of biochemical markers of bone turnover during normal pregnancy and pregnancies complicated by pre-eclampsia

Anim-Nyame¹

2002

BJOG: An International Journal of Obstetrics and Gynaecology

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“…Furthermore, no relationship was observed between bone markers and ALT levels, suggesting that the elevated levels were unlikely to be due to impaired liver metabolism. Dietary calcium intake was not controlled for, but recent evidence suggests that the altered calcium metabolism in pre‐eclampsia is not due to impaired absorption 28 . In this study, the authors observed that renal calcium excretion by both hypocalciuric and normocalciuric symptom‐free primigravid women remote from term were not statistically different.…”

Section: Discussionmentioning

confidence: 58%

A longitudinal study of biochemical markers of bone turnover during normal pregnancy and pregnancies complicated by pre‐eclampsia

Anim-Nyame

Sooranna

Jones

et al. 2002

BJOG

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“…Hypocalciuria in preeclampsia is not due to poor absorption of calcium, as both hypocalciuric and normocalciuric women responded similarly to an oral calcium challenge. 35 It is unlikely that this parameter contributes to a greater increase in the levels of bone markers in preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

Expression of Concern: Bone turnover in preeclampsia‐complicated pregnancy in North Indian women

Kumar

Devi

Prasad

et al. 2011

J of Obstet and Gynaecol

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Calciuria in symptom-free primigravid women remote from term: Is the response to an oral calcium challenge predictable?

Cited by 6 publications

References 6 publications

A longitudinal study of biochemical markers of bone turnover during normal pregnancy and pregnancies complicated by pre-eclampsia

A longitudinal study of biochemical markers of bone turnover during normal pregnancy and pregnancies complicated by pre-eclampsia

A longitudinal study of biochemical markers of bone turnover during normal pregnancy and pregnancies complicated by pre‐eclampsia

Expression of Concern: Bone turnover in preeclampsia‐complicated pregnancy in North Indian women

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