“…This hypothesis has recently been proposed especially for the highest frequencies, in which dielectric and resistive heating could increase the local temperature and increase the entropy of the exposed biologic system (Sheppard et al, 2008). However, a thermal mechanism should be rejected taking into account that: (1) the distance between the antenna and the head drastically reduces the absorbed power (Schö nborn et al, 1999); (2) increase of skin temperature would be easily dissipated through the blood flow (Van Leeuwen et al, 1999); and (3) near-infrared light penetrates through the brain at least 1.5 cm in-depth, in which temperature changes are far below the danger level (Wang and Fujiwara, 1999;Bernardi et al, 2000). Thus, several nonthermal mechanisms could be involved, such as: (1) proteins conformational variations resulting in proteins functional changes; (2) modifications in the binding of ligands, such as Ca + + to cell receptors, also resulting in a changed receptor function; (3) absorption of RF energy by the vibrational states of biologic components, such as microtubules; (4) enhanced attraction amongst cells (the pearl-chain effect); and (5) demodulation of a modulated RF signal, producing extremely lowfrequency electric fields (for a review, see Challis, 2005).…”