We investigate the effect of a return U-bend on flow behaviour in the vertical upward section of a largediameter pipe. A wire mesh sensor was employed to study the void fraction distributions at axial distances of 5, 28 and 47 pipe diameters after the upstream bottom bend. It was found that, the bottom bend has considerable impacts on up-flow behaviours. In all conditions, contour plots of the crosssectional phase distribution measurement using the wire mesh sensor (WMS) show that centrifugal effect of the U-bend causes appreciable misdistribution in the adjacent straight section. However, flow asymmetry significantly reduces at an axial distance of 47D from the U-bend. Flow regime maps generated from three axial locations showed that, in addition to bubbly, intermittent and annular flows, oscillatory flow occurred particularly when gas and liquid flow rates were relatively low. At this position, the mean void fractions were in agreement with those from other large-pipe studies.Comparisons were made with existing void fraction correlations. Among the correlations surveyed, drift flux-type correlations were found to give the best predictive results.