Calculation of direct and indirect damages of Auger electron-emitting radionuclides based on the atomic geometric model: A simulation study using Geant4-DNA toolkit

Ahmadi, Parvin; Zafarghandi, Mojtaba Shamsaei; Shokri, Aliasghar

doi:10.1016/j.nimb.2020.08.007

Nuclear Instruments and Methods in Physics Research Section B:

2020

DOI: 10.1016/j.nimb.2020.08.007

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Calculation of direct and indirect damages of Auger electron-emitting radionuclides based on the atomic geometric model: A simulation study using Geant4-DNA toolkit

Parvin Ahmadi

Mojtaba Shamsaei Zafarghandi

Aliasghar Shokri

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2024

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Cited by 2 publications

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The effects of cell displacement on DNA damages in targeted radiation therapy using Geant4-DNA

Ganjgah,

Taherparvar

2024

Sci Rep

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Charged particle radiation can, directly and indirectly, affect cells by breaking DNA strands. This effect includes DNA single-strand breaks (SSB) and DNA double-strand breaks (DSB), which may cause cell death and mitotic failure. Thus, using short-range charged particles such as Auger electrons (AEs) not only leads to the destruction of the target cell but also prevents the nearby healthy cells from exposing to ionizing radiation. In this study, two spherical cells (C and C 2 ) and their cell nucleus, both made of liquid water, were modeled. An atomic DNA model constructed in the Geant4-DNA Monte Carlo (MC) simulation toolkit was placed inside the nucleus of the C and C 2 cells. The number of direct and indirect SSB, DSB, and hybrid DSB (HDSB), caused by some of the most widely-used Auger electron-emitting (AEE) radionuclides, including 99m Tc, 111 In, 123 I, 125 I, and 201 Tl, distributed within different compartments of the C cell, was calculated in the C and C 2 cells, considering the distance between the surface of the two cells ranges from 0 to 5 μm. The present work aimed to investigate the biological effects of AEE radionuclides and their potential for cancer treatment through targeted radiation therapy. The results indicate the impact of 201 Tl > 125 I > 123 I > 111 In > 99m Tc on DNA damage when the target is C (first spherical cell). On the other hand, for C 2 at distances of 0 to 5 μm, the impact of 99m Tc > 123 I > 111 In > 201 Tl > 125 I on DNA damage is observed.

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The effects of cell displacement on DNA damages in targeted radiation therapy using Geant4-DNA

Ganjgah,

Taherparvar

2024

Sci Rep

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Modelling Potential Candidates for Targeted Auger Therapy

Buchanan,

Aboagye,

Evitts

et al. 2024

Biophysica

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Targeted Auger emitters are being considered as a cancer treatment owing to the high linear energy transfer of Auger electrons. When targeted to cancers, this allows for a highly efficient treatment with a low risk of damage to surrounding healthy tissue. The purpose of this study was to determine the most DNA-damaging Auger emitters from a range of radionuclides, some of which are clinically utilised. A Monte Carlo method-based software (Geant4-DNA version 10.7) was used to determine the energy deposition and number of DNA double-strand breaks from Auger (and internal conversion) electrons imposed on a tetranucleosome. The Auger emitters, 119Sb and 103Pd, have similar or slightly greater damaging properties compared to 123I, 111In, and 89Zr. 193mPt demonstrated the greatest therapeutic potency. Whilst 125I was highly damaging, its relatively long half-life (60 days) makes it less desirable for clinical use. Geant4-DNA modelling identified the radionuclide 193mPt as being highly favourable for use in radiotherapy.

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Calculation of direct and indirect damages of Auger electron-emitting radionuclides based on the atomic geometric model: A simulation study using Geant4-DNA toolkit

Cited by 2 publications

References 50 publications

The effects of cell displacement on DNA damages in targeted radiation therapy using Geant4-DNA

The effects of cell displacement on DNA damages in targeted radiation therapy using Geant4-DNA

Modelling Potential Candidates for Targeted Auger Therapy

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