Calculation of nanoparticle capture efficiency in magnetic drug targeting

Cregg, P.J.; Murphy, Kieran; Mardinoğlu, Adil

doi:10.1016/j.jmmm.2008.06.021

Cited by 36 publications

(25 citation statements)

References 12 publications

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“…Evidently there is not a complete modeling framework and there is no single software package for simulating the entire process, since this would require the integration of multiparticle simulation, molecular simulation, continuum-based models, stochastic methods and nanomechanics. A number of deterministic dynamic modeling approaches for magnetic targeting are presented in (23,78,80,87,88,(96)(97)(98). Nonetheless, critical physical parameters of endovascular navigation are captured by the simplified model depicted in Figure 13, where the untethered nanocapsule is subjected to the apparent weight, magnetic force and torque, and hydrodynamics.…”

Section: Multiscale Modeling and Computational Toolsmentioning

confidence: 99%

MRI-Guided Nanorobotic Systems for Therapeutic and Diagnostic Applications

Vartholomeos

Fruchard

Ferreira

et al. 2011

Annu. Rev. Biomed. Eng.

103

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International audienceThis review presents the state of the art of magnetic resonance imaging(MRI)-guided nanorobotic systems that can perform diagnostic, curative,and reconstructive treatments in the human body at the cellular and subcellular levels in a controllable manner. The concept of an MRI-guided nanorobotic system is based on the use of an MRI scanner to induce the required external driving forces to propel magnetic nanocapsules to a specific target. It is an active targeting mechanism that provides simultaneous propulsion and imaging capabilities, which allow the implementation of real-time feedback control of the targeting process. The architecture of the system comprises four main modules: (a) the nanocapsules, (b) the MRI propulsion module, (c) theMRI trackingmodule (for image processing), and (d ) the controller module. A key concept is the nanocapsule technology, which is based on carriers such as liposomes, polymermicelles, gold nanoparticles, quantum dots, metallic nanoshells, and carbon nanotubes. Descriptions of the significant challenges faced by theMRI-guided nanorobotic system are presented, and promising solutions proposed by the involved research community are discussed. Emphasis is placed on reviewing the limitations imposed by the scaling effects that dominate within the blood vessels and also on reviewing the control algorithms and computational tools that have been developed for real-time propulsion and tracking of the nanocapsules

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Section: Multiscale Modeling and Computational Toolsmentioning

confidence: 99%

MRI-Guided Nanorobotic Systems for Therapeutic and Diagnostic Applications

Vartholomeos

Fruchard

Ferreira

et al. 2011

Annu. Rev. Biomed. Eng.

103

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“…where H 0 is the applied homogeneous magnetic field as in Figure 2 and φ represents the reduced magnetic scalar potential which in the region outside the stent wires is given by [20,19,21] …”

Section: Accepted Manuscriptmentioning

confidence: 99%

Many particle magnetic dipole–dipole and hydrodynamic interactions in magnetizable stent assisted magnetic drug targeting

Cregg

Murphy

Mardinoğlu

et al. 2010

Journal of Magnetism and Magnetic Materials

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The implant assisted magnetic targeted drug delivery system of Avilés, Ebner and Ritter is considered both experimentally (in vitro) and theoretically. The results of a 2D mathematical model are compared with 3D experimental results for a magnetizable wire stent. In this experiment a ferromagnetic, coiled wire stent is implanted to aid collection of particles which consist of single domain magnetic nanoparticles (radius ≈ 10 nm). In order to model the agglomeration of particles known to occur in this system, the magnetic dipole-dipole and hy- A c c e p t e d m a n u s c r i p t PACS: 47.63.mh, 87.85.gf

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“…Thus, the average projection of m the moment in the direction of B total can be calculated from the Langevin function [19,20,6,7,8]…”

Section: Outline Of Modelmentioning

confidence: 99%

“…To overcome these limitations, ferromagnetic materials such as wires, seeds and stents are implanted into the body to increase the local magnetic field strength and this technique is called Implant Assisted Magnetic Drug Targeting (IA-MDT) [5,6,7,8]. Typically IA-MDT models to date have assumed that vessel and implant are considered as rigid and not subjected to any mechanical forces.…”

Section: Introductionmentioning

confidence: 99%

Theoretical modelling of physiologically stretched vessel in magnetisable stent assisted magnetic drug targetingapplication

Mardinoğlu

Cregg

Murphy

et al. 2011

Journal of Magnetism and Magnetic Materials

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The magnetisable stent assisted magnetic targeted drug delivery system in a physiologically stretched vessel is considered theoretically. The changes in the mechanical behaviour of the vessel are analysed under the influence of mechanical forces generated by blood pressure. In this 2D mathematical model a ferromagnetic, coiled wire stent is implanted to aid collection of magnetic drug carrier particles in an elastic tube, which has similar mechanical properties to the blood vessel. A cyclic mechanical force is applied to the elastic tube to mimic the mechanical stress and strain of both the stent and vessel while in the body due to pulsatile blood circulation. The magnetic dipole-dipole and hydrodynamic interactions for multiple particles are included and agglomeration of particles is also modelled. The resulting collection efficiency of the mathematical model shows that the system performance can decrease by as much as 10 % due to the effects of the pulsatile blood circulation.

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Calculation of nanoparticle capture efficiency in magnetic drug targeting

Cited by 36 publications

References 12 publications

MRI-Guided Nanorobotic Systems for Therapeutic and Diagnostic Applications

MRI-Guided Nanorobotic Systems for Therapeutic and Diagnostic Applications

Many particle magnetic dipole–dipole and hydrodynamic interactions in magnetizable stent assisted magnetic drug targeting

Theoretical modelling of physiologically stretched vessel in magnetisable stent assisted magnetic drug targetingapplication

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