In tandem hot strip rolling mills, different friction between the rolls and the strip material on the upper and lower strip surface can occur due to asymmetric surface temperatures or different conditions of oil lubrication. To capture these effects, this paper presents a hydrodynamic roll gap model with asymmetric friction. Based on similarities between the rolled material and viscous fluids, fluid mechanics theory is used to derive this model. Due to the nature of this model, the influence of the rolling speed is inherently taken into account, which allows an accurate prediction of the rolling force and the forward slip. As an analytic solution for the hydrodynamic roll gap model is available, it is well suited for online applications in rolling plants. For validation of the proposed model, an experiment with asymmetric work roll roughness was performed. A specimen of steel strip with copper pins inserted was repeatedly rolled to visualize the material flow inside the roll gap for multiple passes. The resulting deformed copper pins were cut out of the strip and show good agreement with the deformation profiles calculated by the developed model.