Calibrated magnetic resonance hydrometry: An in vitro study

Abstract

Purpose:To demonstrate a quantitative approach to measuring fluid volumes with standard single shot RARE sequences. Materials and Methods:In phantom experiments, magnetic resonance hydrometry (MRH), in combination with various calibration phantoms (5 mL up to 500 mL) as internal standards, was used to quantify fluid volumes. In total, 16 volume phantoms were investigated with six different calibration phantoms. In addition, noise correction was implemented to correct the quantification results and to avoid the influence of random noise in the image.Results: All MR measurements show significant correlations of up to r ϭ 0.99 (P Ͻ .05) with the real applied volume in the investigated phantoms. However, measurements of large volumes were more precise with large calibration phantoms. Noise reduction did not change the correlation between measured and real applied volumes, but did reduce the error of the measured volumes. Calibrated magnetic resonance hydrometry (cMRH) is able to quantify volumes of fluid fast and noninvasively. The volumes of the used calibration phantoms have to be at least in the order of magnitude of the volumes that are to be measured. Conclusion:In vitro, cMRH using a single-shot rapid acquisition with refocused echoes (ssRARE) sequence and calibration phantoms is a fast and accurate method of quantifying steady amounts of fluid.

Quantitative secretin MRCP (MRCPQ): results in 215 patients with known or suspected pancreatic pathology

“…As previously shown in phantom experiments, smaller calibration volumes (<30 ml) would result in more error. Similarly, the position of the internal water control, close to the area of interest, is important to minimise coil and field inhomogeneity effects [14]. If this voxel does not contain 100% water, the calculated flow rate will be spuriously high.…”

Calibrated magnetic resonance hydrometry to quantify pancreatic juice: A preliminary study

“…Recently, some researchers proposed a new method for quantification of pancreatic juice: secretin MR hydrometry (1,2). It was reported that the volume of pancreatic juice secretion significantly correlates with the maximal consistency of bicarbonate in the pancreatic juice after secretin stimulation (3,4); a decrease in the maximal consistency of bicarbonate was proposed as one of the early signs of a deficiency in the pancreatic exocrine function.…”