As for high resolution satellite application field, novel C/SiC honeycomb sandwich structure is the first to propose and develop on account of such many attractive properties as excellent ultrahigh dimensional stability in thermal and moisture coupling environment, lightweight and high load-bearing. Three types of C/SiC honeycomb sandwich structures were fabricated for the first time as opto-mechanical structure in satellite. The innovative interlayer-crosslinking method to weave the continuous carbon fiber fabric of honeycomb core was proposed. The compressive properties of novel C/SiC honeycomb sandwich structures were investigated. Meanwhile, the damage mechanism for sandwich structures were analyzed by non-destructive testing. The results showed that the innovative fabrication processing possessed the capability to prepare high quality C/SiC honeycomb, which was shown from the volume and distribution of pores in the X-ray tomography. The compression modulus and strength of the C/SiC honeycomb reached 927 MPa and 10.76 MPa, and showed better rigidity and higher strength compared with classical honeycombs. Two main types of cracks wall were found in the C/SiC honeycomb, i.e., the horizontal ones in the wall with t thickness and the inclined ones in the wall with 2 t thickness. The outstanding compressive performance was attributed to the high mechanical property of ceramic-matrix composite with fiber pull-out mechanism. The exceptional lightweight capacity was inherited from the low bulk density of honeycomb structure ranged from 0.08 g/cm3 to 0.15 g/cm3. This study can help for the development of lightweight materials for opto-mechanical structure in aerospace optical remote sensing technology.