Calicivirus Emergence from Ocean Reservoirs: Zoonotic and Interspecies Movements

Smith, Alvin W.; Skilling, Douglas E.; Cherry, Neil J.; Mead, Jay H.; Matson, David O.

doi:10.3201/eid0401.980103

Cited by 119 publications

(93 citation statements)

References 15 publications

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“…One serotype of SMSV was reported to infect humans (51,53). The zoonotic potential of feline calicivirus has been suggested by the observation of a human antibody against it (53). More recently, the potential existence of animal reservoirs and the possibility of interspecies transmission have been suggested by the phylogenetic relatedness and classification of bovine and porcine viruses, isolated from the enteric tracts or fecal specimens of infected animals, within the genera Norovirus and Sapovirus, respectively (6,9,20,35,49,57,60).…”

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confidence: 99%

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Inter- and Intragenus Structural Variations in Caliciviruses and Their Functional Implications

Chen¹,

Neill

Noel

et al. 2004

J Virol

125

108

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The family Caliciviridae is divided into four genera and consists of single-stranded RNA viruses with hosts ranging from humans to a wide variety of animals. Human caliciviruses are the major cause of outbreaks of acute nonbacterial gastroenteritis, whereas animal caliciviruses cause various host-dependent illnesses with a documented potential for zoonoses. To investigate inter-and intragenus structural variations and to provide a better understanding of the structural basis of host specificity and strain diversity, we performed structural studies of the recombinant capsid of Grimsby virus, the recombinant capsid of Parkville virus, and San Miguel sea lion virus serotype 4 (SMSV4), which are representative of the genera Norovirus (genogroup 2), Sapovirus, and Vesivirus, respectively. A comparative analysis of these structures was performed with that of the recombinant capsid of Norwalk virus, a prototype member of Norovirus genogroup 1. Although these capsids share a common architectural framework of 90 dimers of the capsid protein arranged on a T‫3؍‬ icosahedral lattice with a modular domain organization of the subunit consisting of a shell (S) domain and a protrusion (P) domain, they exhibit distinct differences. The distally located P2 subdomain of P shows the most prominent differences both in shape and in size, in accordance with the observed sequence variability. Another major difference is in the relative orientation between the S and P domains, particularly between those of noroviruses and other caliciviruses. Despite being a human pathogen, the Parkville virus capsid shows more structural similarity to SMSV4, an animal calicivirus, suggesting a closer relationship between sapoviruses and animal caliciviruses. These comparative structural studies of caliciviruses provide a functional rationale for the unique modular domain organization of the capsid protein with an embedded flexibility reminiscent of an antibody structure. The highly conserved S domain functions to provide an icosahedral scaffold; the hypervariable P2 subdomain may function as a replaceable module to confer host specificity and strain diversity; and the P1 subdomain, located between S and P2, provides additional fine-tuning to position the P2 subdomain.

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confidence: 99%

“…Recent studies have indicated that some animal caliciviruses are capable of crossing species barriers and potentially use humans as their hosts. One serotype of SMSV was reported to infect humans (51,53). The zoonotic potential of feline calicivirus has been suggested by the observation of a human antibody against it (53).…”

mentioning

confidence: 99%

Inter- and Intragenus Structural Variations in Caliciviruses and Their Functional Implications

Chen¹,

Neill

Noel

et al. 2004

J Virol

125

108

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“…In the human household environment, small roundstructured viruses (SRSVs) are a major cause of epidemic gastroenteritis, and 'classic ' human caliciviruses (HuCVs) cause paediatric diarrhoeal disease in humans, while among pets feline calicivirus (FCV) and rabbit haemorrhagic disease virus (RHDV) are major causes of disease in these animals. In recent years these caliciviruses have become the subject of extensive research and numerous studies have addressed the molecular biology, epidemiology and evolutionary aspects of these viruses (for recent reviews see Clarke & Lambden, 1997 ;Smith et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Organization of the canine calicivirus genome from the RNA polymerase gene to the poly(A) tail.

Roerink¹,

Hashimoto²,

Tohya³

et al. 1999

Journal of General Virology

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In recent years a wealth of data has become available about the caliciviruses that infect humans, as well as those which infect a range of animal species, notably cats, rabbits, pigs and marine animals. However, in the two decades since the earliest reports of calicivirus infection in dogs, very little has become known about the epidemiology, pathogenicity and molecular biology of the caliciviruses that may infect canines. In 1990, a canine calicivirus (CaCV) was isolated from a 2-month-old diarrhoeic domestic dog in Japan. This virus, which can be grown in cultured cells of canine origin, has the classic ' Star of David ' morphology of caliciviruses, and the one major structural protein was shown to be immunogenic in dogs. In this study, a 3n8 kb region of the genome of this CaCV isolate from the RNA polymerase gene to the 3h poly(A) tail was cloned and sequenced, and phylogenetic analysis was undertaken in order to establish the relationship of CaCV to other animal and human caliciviruses. This CaCV isolate had a nucleotide sequence, genomic organization and phylogenetic position closest to, but clearly distinct from, both feline calicivirus and San Miguel sea lion virus isolates. These findings suggest that CaCV represents a new clade of animal caliciviruses, presumably as a member of the recently proposed new genus Vesivirus.

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“…GGV. Nach heu ti gem Kennt nis stand kann nicht aus ge schlos sen wer den, dass ei ni ge ani male Ca li ci vi ren durch aus die Spe zies bar riere Tier-Mensch über win den kön nen [17]. In wie weit ein ge wis ses zo o no ti sches Po tenzi al zur enor men Va ri a bi li tät un ter den Noro vi ren be reits bei ge tra gen hat oder erst bei tra gen wird, bleibt wei te ren mo le kular ge ne ti schen Un ter su chun gen vor be halten.…”

Section: Va Ri a Bi LI Tätunclassified

Norovirusinfektionen in Deutschland

Koch

Schneider

Stark

et al. 2006

Bundesgesundheitsbl - Gesundheitsforsch - Gesundheitsschutz

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No ro vi rus in fek tio nen in Deutsch landBun des ge sund heits bl -Ge sund heits forschGe sund heits schutz 2006 · 49:296- Hin ter grund und Ta xo no mieOb wohl ers te Be rich te über Ma gen-DarmEr kran kun gen (Ga stro en te ritiden) be reits vor mehr als 5000 Jah ren in Hie ro gly phenschrif ten auf Pa py rus ver fasst wur den, konn ten erst seit dem ver gan ge nen Jahrhun dert en te ro pa tho ge ne Vi ren als po tenzi el le Er re ger di ag nos tisch ein ge grenzt werden. Dies be züg lich war der im mu n elektro nen mi kro sko pi sche Nach weis von ca. 30 nm gro ßen Par ti keln 1972 durch Ka pi kian et al. [1] in Stuhl pro ben von Frei wil li gen, die mit Stuhl fil trat aus ei nem Ga stro en te ritis aus bruch von 1968 in der Stadt Nor walk im Bun des staat Ohio/USA in fi ziert wurden, ein Durch bruch für die Auf klä rung nicht bak te ri ell ver ur sach ter aku ter Ga stroen te ritiden. In der Fol ge wur den dann weite re Vi ren als ätio lo gi sches Agens epi de mischer und spo ra di scher Ga stro en te ritiden iden ti fi ziert. Heu te ist das zu nächst nach dem Her kunfts ort be nann te Nor walk vi rus (bzw. die Nor walk-like-Vi ren) ne ben dem Ro ta vi rus das be herr schen de vi ra le Agens in fek ti öser Ga stro en te ri tis [2]. Ge mäß einer Fest set zung des In ter na tio nal Com mittee on Ta xo no my of Vi ru ses er folg te Ende 2002 eine Um be nen nung der Nor walklike-Vi ren in No ro vi ren (NV).Ob wohl das No ro vi rus nicht die cha rakte ris ti sche Ca li ci vi rus mor pho lo gie zeigt, wie sie z. B. für das Sa po vi rus (vor mals Sapo ro-like-Vi rus) be kannt ist (. Abb. 1), wur de es doch auf grund sei ner Ge nomstruk tur und -or ga ni sa ti on der Fa mi lie der Ca li ci vi ri dae zu ge ord net. Heu te dif fe renziert man in die ser Vi rus fa mi lie zwi schen 4 Ge ne ra (. Ta bel le 1), den Noro-, Sapo-, Vesi-und La go vi ren [3]. Auf der Grund lage phy lo ge ne ti scher Stu di en (Nu kle in säu-re se quenz ver gleichs ana ly sen) ge hö ren zu dem Ge nus No ro vi rus auch 2 nicht-human pa tho ge ne Vi ren, das Je na vi rus (JV) [4] und das kürz lich ent deck te Maus no rovi rus (MNV) [5]. Vi ro lo gieNo ro vi ren wer den auf grund ih rer Morpho lo gie als klei ne, run de struk tu rier te Vi ren (small round struc tu red vi ru ses) bezeich net. Sie be sit zen eine li nea re, 3'-termi nal po ly ade ny lier te Ein zel strang-RNA po si ti ver Po la ri tät (Grö ße: ca. 7,5 Kb). Das 5'-Ende des Ge noms wird von einem vi rus ko dier ten Pro te in (VPg) flankiert. Die vi ra le RNA ko diert über 3 diffe ren te of fe ne Le serah men (ORF1, 2 und 3) die Nicht struk tur-und Struk tur pro te ine (. Abb. 2) [6,7]. Der ers te of fe ne Leserah men (ORF1, ca. 5100-5300 Nk umfas send) ko diert ein Po ly pro te in, das nach pro teo ly ti scher Spal tung in 6 Nichtstruk tur pro te i ne pro zes siert wird. Über die Funk ti on der Nicht struk tur pro te i ne im vi ra len Re pli ka ti ons zy klus gibt es derzeit nur be grenz te In for ma tio nen. Die funk tio nel le Be deu tung der Nicht struktur pro te i ne wird meh...

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Calicivirus Emergence from Ocean Reservoirs: Zoonotic and Interspecies Movements

Cited by 119 publications

References 15 publications

Inter- and Intragenus Structural Variations in Caliciviruses and Their Functional Implications

Inter- and Intragenus Structural Variations in Caliciviruses and Their Functional Implications

Organization of the canine calicivirus genome from the RNA polymerase gene to the poly(A) tail.

Norovirusinfektionen in Deutschland

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