Calixarene modified montmorillonite: a novel design for biosensing applications

Abstract

Here we report the synthesis, characterization and application of calixarene (Calix) modified montmorillonite (Mt) as a platform for bio-applications such as biomolecule immobilization and biosensing technologies.

Synthesis of new anthracene‐substituted calix[4]triazacrown‐5 as highly sensitive fluorescent chemosensor and extractant against hazardous dichromate anion

“…The aim of this work was the synthesis of a new calixarene-based fluorogenic chemosensor and an efficient extractant towards hazardous dichromate anion. For this purpose, calix [4]arene diester (3) [26][27][28] was treated with diethylene triamine in a mixture of toluene and EtOH (1:1) to obtain calix [4]triazacrown-5 (4) [29,30] at cone conformation (see Scheme 1). A simple Schiff's base reaction for calix [4] triazacrown-5 (4) with 9-anthracenecarboxaldehyde in a mixture of THF and MeOH (1:3) gave a new calixarene derivative (Ant-AzClx)…”

“…The compounds p-tert-butylcalix [4]arene (1), calix [4]arene (2), 1,3-Odimethyl ester calix [4]arene derivative (3) and calix [4]triazacrown-5 (4) were synthesized according to literature procedures. [26][27][28][29][30] The anthracene functionalized calix [4]triazacrown-5 (Ant-AzClx) is synthesized here for the first time. To a mixture of calix [4]triazacrown-5 (4) (542.7 mg, 0.834 mmol) in CH 3 OH (10 ml) were added a solution of 9-anthracene carboxaldehyde (0.206 g, 1.0 mmol) in 10 ml tetrahydrofuran (THF), and the reaction mixture was stirred under reflux.…”

New Trends in Nanoclay-Modified Sensors

“…Enzymatic glucose biosensors based on nanoclays have recently acquired attention due to their good performance in terms of detection limit, stability, sensibility, and selectivity for in vitro glucose determination from human biological fluids [57][58][59]. Several authors have applied raw and functionalized clays in biosensors' preparation for glucose detection, as stated in Table 5 [60][61][62][63][64][65][66][67][68][69][70][71][72]. A schematic representation of an enzyme biosensor based on electrode with nanoclay for glucose determination is shown in Figure 3 [23].…”

“…Sonmez et al [63] reported the synthesis, characterization, and application of calixarene (Calix)-modified montmorillonite as a platform for biomolecule immobilization and biosensing. This modification enhanced the biomolecule immobilization capability of Mt.…”

Polyglycolide–montmorillonite as a novel nanocomposite platform for biosensing applications

“…7 Mt has the widest application potential in bio-based detection technologies due to attainability, well identified intercalation/exfoliation chemistry, and high surface area. In our previous studies, methyl amine, dimethylamine, 8 trimethylamine, 9 amino acid (glycine, lysine, and glutamic acid, histidine), 10,11 and calixarene 12 intercalated Mt were used as attachment platforms to prepare glucose oxidase, pyranose oxidase (POx), laccase and microbial biosensors. Clay nanocomposites also have attracted a lot of attention in recent years.…”