Callystatin A, a potent cytotoxic polyketide from the marine sponge, Callyspongia truncata

Pterocidin, a Cytotoxic Compound from the Endophytic Streptomyces hygroscopicus

“…Similar polyketidederived d-lactones have been isolated from actinomycetes [8ϳ12] and marine sponges [13,14] and many of them show antitumor activity. The structure of 1 is closely related to sultriecin [8], PD 113271 [9], and pironetin [10], antitumor compounds produced by Streptomyces species.…”

“…The molecular formula of 1 was established to be C 23 H 34 O 6 based on 13 (Table 1) revealed the presence of signals due to one carbonyl carbon, one oxygenated sp 2 quaternary carbon, nine sp 2 methines, four sp 3 methines adjacent to oxygen atoms, one sp 3 methine, two sp 3 methylenes, three methoxy groups, and two methyls. Since six out of 7 unsaturations were accounted for, 1 was inferred to possess one ring.…”

Analytical characterization and structure elucidation of metabolites from Aspergillus ochraceus MP2 fungi

“…Results: Three bioactive compounds were characterized to reveal their identity, chemical formula and structure. The Contents lists available at ScienceDirect which live in the canals, between cells, and even inside the cell [11] . A variety of antimicrobial substances have been isolated from various species of marine sponges [12] .…”

6-Hydroxymethyl-1-phenazine-carboxamide and 1,6-phenazinedimethanol from a marine bacterium, Brevibacterium sp. KMD 003, associated with marine purple vase sponge

“…[1][2][3][4] Marine sponges of genus Callyspongia have been shown to contain bioactive secondary metabolites such as pyridine alkaloids, 5 polyacetylenes, 6 peptides, 7 sulfated meroterpenoids 8 and polyketide. 9 However, little is known about the secondary metabolite production of microbes derived from Callyspongia. To date, only two cultured microbes, a carotenoid-producing Streptomyces sp.…”