Caloric restriction induced epigenetic effects on aging

Zhai, Jingfang; Kongsberg, William H.; Pan, Yinbo; Hao, Canhua; Wang, Xiaojing; Sun, Jie

doi:10.3389/fcell.2022.1079920

Cited by 16 publications

(6 citation statements)

References 225 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recent discoveries in the anatomy of the facial fat compartment have conceptually and interventionally revolutionized the approach to adding volume to specific deflated soft tissue compartments, creating a more individualized youthful restoration of the face [48,49]. Rendering or even reconstructing the characteristics of facial youth starts from the skeletal structure and goes progressively up to the SMAS.…”

Section: Anatomical Base Of Modern Surgery-superficial Musculoaponeur...mentioning

confidence: 99%

“…CR studies continued to develop throughout the 20th century. A 2020 study fed rats with fewer calories than their ad-libitum counterparts and found that 57% of the age-related genetic changes that occurred in normal rats did not occur in calorie-restricted rats [49]. MRI or CT imaging of SMAS are also evolving to demask its implications into the phenomena of the aging face [50][51][52].…”

Section: Anatomical Base Of Modern Surgery-superficial Musculoaponeur...mentioning

confidence: 99%

See 1 more Smart Citation

Personalized Research on the Aging Face—A Narrative History

Hînganu,

Cucu,

Hînganu

2024

JPM

View full text Add to dashboard Cite

Throughout history, people have struggled to find out the secret of youth. The aim of the manuscript is to review the main achievements regarding the exploration of the aging face phenomenon. It should be very important to know the evolution in this field due to the increase in life expectancy among the population. Our purpose is for the current study to serve as a starting point towards exploring novel research avenues in molecular biology and the confocal immunofluorescence of cervicofacial soft tissues, employing cutting-edge techniques. All changes in the shape of the facial skeleton, soft tissue, retaining ligaments, fat compartments, and the skin envelope contribute to facial aging to varying degrees.

show abstract

Section: Anatomical Base Of Modern Surgery-superficial Musculoaponeur...mentioning

confidence: 99%

Section: Anatomical Base Of Modern Surgery-superficial Musculoaponeur...mentioning

confidence: 99%

Personalized Research on the Aging Face—A Narrative History

Hînganu,

Cucu,

Hînganu

2024

JPM

View full text Add to dashboard Cite

show abstract

“…Eating an unhealthy diet with calorie excess will certainly promote the development of atherosclerosis, ISR, and ST [64]. CR protects DNA methylation, histone modification, and non-coding RNA (nc-RNA), which prevent VSMC proliferation, migration, and inflammation, which play an important role in developing atherosclerosis and ISR [65,66]. Most individuals who follow PBDs generally do not necessitate CR since these diets inherently promote a sense of satiety.…”

Section: Caloric Restriction Is An Essential Factor In Combating Infl...mentioning

confidence: 99%

How a Plant-Based Diet (PBD) Reduces In-Stent Restenosis (ISR) and Stent Thrombosis (ST)

2024

Cardio Open

View full text Add to dashboard Cite

Despite the advances in stent design, coating drugs, polymers, the use of intravascular imaging, special devices (such as intravascular lithotripsy, ultra-high-pressure non-compliant balloons, and drug-coated balloons), and improved operator skills and techniques, the problem of in-stent restenosis (ISR) and stent thrombosis (ST) remains a challenge for interventional cardiologists. Atherosclerotic lesions, ISR, and ST, are systemic metabolic chronic inflammatory illnesses with a local manifestation in the coronary vessels. Therefore, we propose managing these systemic illnesses systemically through plant-based diet (PBD) intervention. We explain how PBD intervention can help mitigate atherosclerosis, ISR, and ST. Thus, PBD intervention can overcome biological and epigenetic problems in managing ISR and ST similarly to reversing atherosclerosis. Our team is pioneering the implementation of PBD for cardiology patients who have undergone coronary intervention. So far, the results have been very promising. We hope that in the future, many research studies will be performed to investigate further the role of PBD in decreasing the incidence of ISR and ST

show abstract

“…Обмеження калорій (ОК) вважають найбільш фізіологічним індуктором аутофагії [40][41][42]. Зростає число даних про те, що старіння сповільнюють харчові продукти, які містять природні сполуки ресвератрол, катехіни (зокрема, ґаллат епіґаллокатехіну (повністю англійською, EGCG), який у великих кількостях присутній у чаї), екстракт прополісу, креозол і флавон лютеолозід (флавон, різновид флавоноїду).…”

Section: аутофагія в умовах обмеження калорійunclassified

Biomedical significance of the therapeutic use of autophagy (literature review)

Sribna

2024

ECM

View full text Add to dashboard Cite

Autophagy, or is an intracellular degradation pathway for improperly functioning aggre-gation-prone proteins, damaged organelles, unwanted macromolecules, and invading patho-gens. The process is necessary for maintaining cell and tissue homeostasis, which contributes to the survival of the organism, and is actively studied. The purpose of this work was the search, selection and analysis of the literature on autophagy as one of the main mechanisms of maintaining cellular homeostasis under conditions of oxidative stress; cellular aging; calo-rie restriction; as well as about the targeted effect on autophagy in the conditions of various diseases. The following generalizations were made: 1) the ability to be directly activated in response to the intense formation of reactive oxygen species in cells allows us to consider autophagy as an important element of antioxidant protection, therefore, the study of ways and means of effective autophagy management is becoming relevant today; 2) dietary con-sumption of autophagy activators may promote health and extend lifespan through multiple mechanisms, including reduction of oxidative stress, induction of autophagy, and suppression of inflammation; 3) studies aimed at elucidating the role of sirtuins, which are key regulators of cellular metabolism and oxidative stress, are gaining relevance in the initiation of autoph-agy. Currently, sirtuin-dependent mechanisms of autophagy require research in experimental models using mammalian cells; 4) continuing the study of autophagy processes will allow a better understanding of physiological aspects and help ensure progress in the development of new strategies for the prevention and treatment of human diseases (including those related to age); 5) autophagy is crucial for cellular physiology, autophagy dysfunction is in-volved in the pathogenesis of various human diseases, and therefore the therapeutic use of autophagy has potential biomedical significance. Keywords: cell death, cellular homeostasis, oxidative stress, cellular aging, calorie restriction, targeted effect on autophagy.

show abstract

Caloric restriction induced epigenetic effects on aging

Cited by 16 publications

References 225 publications

Personalized Research on the Aging Face—A Narrative History

Personalized Research on the Aging Face—A Narrative History

How a Plant-Based Diet (PBD) Reduces In-Stent Restenosis (ISR) and Stent Thrombosis (ST)

Biomedical significance of the therapeutic use of autophagy (literature review)

Contact Info

Product

Resources

About