Calorie Restricted Diet and Urinary Pentosidine in Patients with Rheumatoid Arthritis

Iwashige, Kenichi; Kouda, Katsuyasu; Kouda, Mitsuo; Horiuchi, K.; Takahashi, Masaaki; Nagano, Akira; Tanaka, Toshiro; Takeuchi, Hisanao

doi:10.2114/jpa.23.19

Cited by 45 publications

(24 citation statements)

References 44 publications

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“…We conducted a regimen of caloric restriction combined with fasting in patients with rheumatoid arthritis, and then evaluated urinary pentosidine levels. Pentosidine was significantly decreased at the end of the study (day 54) [40]. The study showed that under a low energy diet, a reduction of disease activity in rheumatoid arthritis was accompanied by a reduction of urinary pentosidine.…”

Section: Rodriguez-garcia Et Al Measured Serum Pentosidine In Patienmentioning

confidence: 74%

Pentosidine, an Advanced Glycation Endproduct, and Arthritis

Takahashi¹

2006

CRR

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Pentosidine is one of the advanced glycation end-products (AGEs). Its significant elevation was firstly observed in diabetes mellitus, and later found in patients with end-stage renal failure. In addition, during the aging process, pentosidine accumulates in the extracellular matrix and causes insolubility and protease resistance of extracellular matrix proteins. In cartilage, pentosidine is crosslinked in collagen and proteoglycan, and thus increases the stiffness of the cartilage. Carbonyl stress, oxidative stress and aging progress the formation and accumulation of pentosidine. In arthritis, a significant elevation of pentosidine was found in rheumatoid arthritis and moreover in osteoarthritis. This review will discuss the relationship between pentosidine and arthritis, and its role as a potential marker for arthritis.

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Section: Rodriguez-garcia Et Al Measured Serum Pentosidine In Patienmentioning

confidence: 74%

Pentosidine, an Advanced Glycation Endproduct, and Arthritis

Takahashi¹

2006

CRR

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“…Our results differ from those observed in patients with rheumatoid arthritis. In the latter condition, a decrease in AGEs was observed after consecutive cycles of fasting and caloric restriction [44]; however, the entire intervention period was much longer than in our study protocol, and the primary endpoint was the urinary pentosidine level. We were only able to measure CML, a non-cross-linking type of AGEs, which may not be as strongly involved in the deterioration of cartilage integrity as is pentosidine.…”

Section: Discussionmentioning

confidence: 99%

AGE-RAGE Interaction Does Not Explain the Clinical Improvements after Therapeutic Fasting in Osteoarthritis

et al. 2017

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Background: Therapeutic fasting improves joint pain in patients with osteoarthritis (OA), but the underlying mechanisms are unknown. Interactions of advanced glycation end products (AGEs) and their receptors (RAGE) play a role in OA pathogenesis. This study aimed to investigate whether the benefits of fasting in OA can be explained by changes in AGEs or RAGE. Patients and Methods: 37 patients with OA underwent fasting for 8 days. Serum levels of an AGE (N-ε-(carboxymethyl)-lysine; CML) and the soluble RAGE (sRAGE) as well as clinical outcome parameters such pain characteristics (measured by visual analogue scale; VAS), joint function (determined by the Western Ontario and McMaster Universities Arthritis Index; WOMAC), and quality of life (via the 36-Item Short-Form Health Survey (SF-36) questionnaire) were assessed. The variables were measured at baseline, the end of fasting, and at follow-up at 4 weeks. Results: The CML levels did not significantly change from baseline to the end of intervention (Δ = -25.6 ± 92.2 ng/ml; p = 0.10). In contrast, the sRAGE levels (Δ = -182.7 ± 171.4 ng/ml; p < 0.0001) and the sRAGE/CML ratio (Δ = -0.4 ± 0.6; p < 0.001) significantly decreased, but they returned to baseline levels 4 weeks after the end of fasting. The scores for pain, WOMAC, and the physical subscale of the SF-36 significantly improved during fasting. There was no correlation between the clinical outcomes and changes in serum levels of CML, sRAGE, or the sRAGE/CML ratio. Conclusions: Fasting resulted in a significant but non-sustained reduction of sRAGE levels and the sRAGE/CML ratio in OA, while the CML levels did not change. Improvement in clinical endpoints of OA does not correlate with changes in CML or sRAGE.

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“…There are no controlled long-term studies of reduced energy intake without mal-nutrition on patients with RA. However, Iwasahige et al [19] recently conducted a regiment for 54 days of caloric restriction combined with fasting in ten patients with RA. The patients lost in weight, and interestingly, the composite disease activity score of Lansbury was significantly reduced.…”

Section: Discussionmentioning

confidence: 99%

Weight reduction is not a major reason for improvement in rheumatoid arthritis from lacto-vegetarian, vegan or Mediterranean diets

Sköldstam

Brudin²,

Hagfors

et al. 2005

Nutr J

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Objectives: Several investigators have reported that clinical improvements of patients with rheumatoid arthritis (RA), from participating in therapeutic diet intervention studies, have been accompanied by loss of body weight. This has raised the question whether weight reduction per se can improve RA. In order to test this hypothesis, three previously conducted diet intervention studies, comprising 95 patients with RA, were pooled. Together with Age, Gender, and Disease Duration, change during the test period in body weight, characterised dichotomously as reduction or no reduction (dicho∆Body Weight), as well as Diet (dichotomously as ordinary diet or test diet), were the independent variables. Dependent variables were the difference (∆) from baseline to conclusion of the study in five different disease outcome measures. ∆ESR and ∆Pain Score were both characterised numerically and dichotomously (improvement or no improvement). ∆Acute Phase Response, ∆Physical Function, and ∆Tender Joint Count were characterised dichotomously only. Multiple logistic regression was used to analyse associations between the independent and the disease outcome variables.Results: Statistically significant correlations were found between Diet and three disease outcome variables i.e. ∆Acute-Phase Response, ∆Pain Score, and ∆Physical Function. ∆ Body Weight was univariately only correlated to ∆Acute-Phase Response but not significant when diet was taken into account. Conclusion:Body weight reduction did not significantly contribute to the improvement in rheumatoid arthritis when eating lacto-vegetarian, vegan or Mediterranean diets.

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Calorie Restricted Diet and Urinary Pentosidine in Patients with Rheumatoid Arthritis

Cited by 45 publications

References 44 publications

Pentosidine, an Advanced Glycation Endproduct, and Arthritis

Pentosidine, an Advanced Glycation Endproduct, and Arthritis

AGE-RAGE Interaction Does Not Explain the Clinical Improvements after Therapeutic Fasting in Osteoarthritis

Weight reduction is not a major reason for improvement in rheumatoid arthritis from lacto-vegetarian, vegan or Mediterranean diets

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