Pentosidine, an Advanced Glycation Endproduct, and Arthritis

Takahashi, Masaaki

doi:10.2174/157339706778699797

Cited by 7 publications

(5 citation statements)

References 31 publications

(43 reference statements)

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“…3) Also we did not include papers that only cover a specific disease (such as Diabetes) to increase external validity. As mentioned previously, AGE’s have an effect on different types of human tissues [ 24 , 26 , 31 , 32 ]. It must be considered that other AGE’s-induced effects, such as effects on the nervous system, ligaments, tendons or joint capsules, could contribute to the decline of physical performance and functions.…”

Section: Discussionmentioning

confidence: 99%

“…Cross-linking AGE’s are responsible for an increasing proportion of insoluble extracellular matrix and thickening of tissue as well as increasing mechanical stiffness and loss of elasticity [ 12 , 22 , 23 ]. Cross-linking AGE’s are considered as being involved in the pathophysiology of arthritis [ 24 , 25 ]. In fact, the accumulation of AGE’s in human articular cartilage increases cartilage stiffness and brittleness.…”

Section: Introductionmentioning

confidence: 99%

“…Consequently, the cartilage becomes increasingly prone to damage and degeneration [ 26 , 27 ]. In rheumatoid arthritis, elevated levels of cross-linking AGE’s in serum and/or synovial fluids also appear to correlate with the levels of inflammatory markers and the disease activity [ 24 ]. Another impact on the musculoskeletal system is within the skeletal bone where AGE-induced crosslinks in the collagen matrix alter the mechanical properties of bone by increasing stiffness and fragility [ 27 – 29 ].…”

Section: Introductionmentioning

confidence: 99%

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The Contribution of Advanced Glycation End product (AGE) accumulation to the decline in motor function

Drenth

Zuidema

Bunt

et al. 2016

Eur Rev Aging Phys Act

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Diminishing motor function is commonly observed in the elderly population and is associated with a wide range of adverse health consequences. Advanced Glycation End products (AGE’s) may contribute to age-related decline in the function of cells and tissues in normal ageing. Although the negative effect of AGE’s on the biomechanical properties of musculoskeletal tissues and the central nervous system have been previously described, the evidence regarding the effect on motor function is fragmented, and a systematic review on this topic is lacking. Therefore, a systematic review was conducted from a total of eight studies describing AGE’s related to physical functioning, physical performance, and musculoskeletal outcome which reveals a positive association between high AGE’s levels and declined walking abilities, inferior ADL, decreased muscle properties (strength, power and mass) and increased physical frailty. Elevated AGE’s levels might be an indication to initiate (early) treatment such as dietary advice, muscle strengthening exercises, and functional training to maintain physical functions. Further longitudinal observational and controlled trial studies are necessary to investigate a causal relationship, and to what extent, high AGE’s levels are a contributing risk factor and potential biomarker for a decline in motor function as a component of the ageing process.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Contribution of Advanced Glycation End product (AGE) accumulation to the decline in motor function

Drenth

Zuidema

Bunt

et al. 2016

Eur Rev Aging Phys Act

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“…27,28 The source of pentosidine production is glycosidation and oxidative stress, which may be mainly associated with pentosidine production in RA. HOCl is also produced by neutrophils and leads to the generation of dicarbonyls or pentoses, which produce pentosidine in the last stage.…”

Section: Discussionmentioning

confidence: 99%

Methotrexate reduces the levels of pentosidine and 8-hydroxy-deoxy guanosine in patients with rheumatoid arthritis

et al. 2007

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This study was performed to investigate whether methotrexate (MTX) affects the levels of oxidative stress markers, including pentosidine one of the glycation end products (AGEs) or 8-hydroxy-deoxy guanosine (8-OHdG). These stress markers represent DNA damage; 19 rheumatoid arthritis (RA) patients underwent MTX treatment. The levels of serum total, urinary total, urinary-free pentosidine and also urinary 8-OHdG, as well as clinical parameters, including disease activity scores for 28 joints (DAS28) were measured at baseline and at 3 and 6 months after the initial treatment with MTX. After the initial treatment with MTX, serum total and urinary total pentosidine levels were reduced at 6 months, and urinary-free pentosidine levels were reduced at 3 and 6 months. Urinary 8-OHdG levels also were significantly reduced at 6 months after the initial treatment with MTX. This study demonstrated that MTX plays a role as a regulator against pentosidine formation and oxidative DNA damage in RA patients.

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“…Molecular structure of pentosidine. It is comprised of a ribose compound connected to a lysine and arginine residue (Takahashi 2006). estimates of unknown-aged birds.…”

Section: Goals and Objectivesmentioning

confidence: 99%

Development and evaluation of a minimally invasive sampling technique to estimate the age of living birds

Cooey¹

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Development of a Minimally Invasive Sampling Technique to Estimate the Age of Living Birds Crissa K. Cooey Using pest species in initial studies of pentosidine (Ps) aging research for birds may be the catalyst to discovering more effective population control strategies for pest, invasive, and hard to manage birds. Pentosidine is an irreversible, stable, fluorescent, collagen cross-link, created through the Maillard reaction, which has been found to accumulate throughout the lifetime of an organism in various body parts such as skin, lens crystalline, and dura matter. Pentosidine assays are more accurate at determining the age of adult birds in comparison to plumage coloration, eye and mouth color, feather wear, and molt sequences due to the discovery that Ps accumulates with age in the skin of birds. Past studies, however, have only taken place on deceased birds. To be considered a more generally useful tool for wildlife management studies, a procedure to obtain skin samples from living birds is needed. The objective of this project was to develop a minimally invasive sampling technique to age live birds through Ps analysis by 1) determining if differences exist in Ps concentration between the breast and patagium of black vultures (Coragyps atratus), monk parakeets (Myiopsitta monachus), and double-crested cormorants (Phalacrocorax auritus), 2) determining if differences exist in Ps concentration of 6 mm 2 and 20 mm 2 skin samples, and 3) determining if healing rates differ between the breast and patagium and between wounds closed with tissue glue and wounds closed with sutures. Pentosidine concentrations were similar between the breast (x = 8.9 pmol/mg collagen, SE = 0.55) and patagium (x = 8.9 pmol/mg collagen, SE = 0.51) of black vultures (P = 0.97) as well as the breast (x = 11.2 pmol/mg collagen, SE = 1.10) and patagium (x = 10.6 pmol/mg collagen, SE = 1.10) of deceased double-crested cormorants (P = 0.10). Pentosidine, however, was significantly higher in the breast (x = 15.9 pmol/mg collagen, SE = 1.30) than the patagium (x = 11.5 pmol/mg collagen, SE = 1.10) of monk parakeets (P < 0.0001). The Ps concentration was marginally higher in 6 mm 2 skin samples (x = 12.6 pmol/mg collagen, SE = 1.19) when compared to 20 mm 2 skin samples (x = 11.3 pmol/mg collagen, SE = 1.23) of cormorants (P = 0.02). Four new age curves were developed for cormorants (our linear breast skin age curve, our curvilinear breast skin age curve, our linear patagial skin age curve, and our curvilinear patagial skin age curve) and compared to the original Fallon age curve. Age estimates and actual ages for cormorant breast and patagial skins were found to be similar when using our linear and curvilinear breast and patagial skin age curves, but there were significant differences between actual and estimated ages for breast and patagial skin when using the Fallon age curve (P <0.0001 and P <0.0001 respectively). The mean estimated ages for all 5 age curves were found to be accurate to within approximately 1½ years (17.4 months). For 6 mm 2...

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Pentosidine, an Advanced Glycation Endproduct, and Arthritis

Cited by 7 publications

References 31 publications

The Contribution of Advanced Glycation End product (AGE) accumulation to the decline in motor function

The Contribution of Advanced Glycation End product (AGE) accumulation to the decline in motor function

Methotrexate reduces the levels of pentosidine and 8-hydroxy-deoxy guanosine in patients with rheumatoid arthritis

Development and evaluation of a minimally invasive sampling technique to estimate the age of living birds

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