Calorie restriction improves aging-induced impairment of cognitive function in relation to deregulation of corticosterone status and brain regional GABA system

Chakraborty, Apala; Banerjee, Subrata; Mukherjee, Biswajit; Poddar, Mrinal K.

doi:10.1016/j.mad.2020.111248

Cited by 17 publications

(12 citation statements)

References 93 publications

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“…Gut microbiota have been reported to preferentially ferment peptides over free amino acids [141], and some peptides possess high resistance against gastrointestinal digestion [142]; therefore, these peptides can affect the composition of gut microbiota and can be utilized by the gut microbiota to produce neurotransmitters, such as butyrate [141], which may improve the negative symptoms of neurodegenerative diseases [143]. In fact, butyrate greatly regulates immune functions and energy metabolism of hosts, and mediates host-microbe crosstalk through transporters (MCT1/SLC16A1; SMCT1/SLC5A8) and specific receptors (GPR43/FFAR2; GPR41/FFAR3; GPR109a/HCAR2).…”

Section: Gut Microbiota and Pdmentioning

confidence: 99%

Fermented Soy Products: Beneficial Potential in Neurodegenerative Diseases

Jang

Lim

et al. 2021

Foods

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Fermented soybean products, such as cheonggukjang (Japanese natto), doenjang (soy paste), ganjang (soy sauce), and douchi, are widely consumed in East Asian countries and are major sources of bioactive compounds. The fermentation of cooked soybean with bacteria (Bacillus spp.) and fungi (Aspergillus spp. and Rhizopus spp.) produces a variety of novel compounds, most of which possess health benefits. This review is focused on the preventive and ameliorative potential of fermented soy foods and their components to manage neurodegenerative diseases, including Alzheimer’s and Parkinson’s diseases.

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Section: Gut Microbiota and Pdmentioning

confidence: 99%

Fermented Soy Products: Beneficial Potential in Neurodegenerative Diseases

Jang

Lim

et al. 2021

Foods

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“…During aging, the deterioration in neurohormonal, neurobiochemical (Banerjee et al., 2019; Chakraborty et al., 2020; Oettel & Mukhopadhay, 2004) including antioxidant (Banerjee et al., 2020; Boldyrev et al., 2013; Hipkiss, 2009) systems makes the neural microenvironment vulnerable to oxidative or nitrosative stress, often leading to proteinopathies and consequent neurodegeneration (Green et al, 2006; Fukumoto et al, 1996; Banerjee et al., 2019). Carnosine, being a potential endogenous antioxidant, with its unique physicochemical properties, helps to maintain a normal physiological microenvironment by counteracting oxidative and nitrosative stress in biological system (Banerjee & Poddar, 2020; Boldyrev et al., 2013; Hipkiss, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…During aging, the deterioration in neurohormonal, neurobiochemical (Banerjee et al, 2019;Chakraborty et al, 2020;Oettel & Mukhopadhay, 2004) including antioxidant (Banerjee et al, 2020;Boldyrev et al, 2013;Hipkiss, 2009) systems makes the neural microenvironment vulnerable to oxidative or nitrosative stress, often leading to proteinopathies and consequent neurodegeneration (Green et al, 2006;Fukumoto et al, 1996;Banerjee et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…The cognitive function of the rats was assessed using an 8‐arm radial maze [constructed with a 45‐cm radius circular platform from which eight arms (58‐cm long and 16.5‐cm wide) radiated out at an angle of 45° as shown in Figure 4] according the method described by Chakraborty et al., (2020). Briefly, the rats were habituated to the maze for 10 min one day prior to the initiation of the shaping trials.…”

Section: Methodsmentioning

confidence: 99%

“…Treatments with exogenous carnosine can restore the aging‐induced deterioration of different neurotransmitter systems (Banerjee et al., 2015; Boldyrev et al., 2013; Kyriazis, 2010), post‐synaptic receptors (Banerjee & Poddar, 2016), and their metabolizing enzymatic activities (Banerjee & Poddar, 2015, 2020; Peters et al., 2012) in various brain regions. The reduction in levels of neurotransmitters and functioning of antioxidant systems during aging have been related to neurodegeneration and cognitive impairment (Chakraborty et al., 2020; Zarrindast, 2006), as well as proteinopathies (Marsh & Alifragis, 2018; Russell et al., 2012).…”

Section: Introductionmentioning

confidence: 99%

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Carnosine improves aging‐induced cognitive impairment and brain regional neurodegeneration in relation to the neuropathological alterations in the secondary structure of amyloid beta (Aβ)

Banerjee

Mukherjee

Poddar

et al. 2021

Journal of Neurochemistry

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Aging‐induced proteinopathies, including deterioration of amyloid beta (Aβ) conformation, are associated with reductions in endogenous levels of carnosine and cognitive impairments. Carnosine is a well‐known endogenous antioxidant, which counteracts aging‐induced Aβ plaque formation. The aim of this study was to investigate the effects of exogenous carnosine treatments on aging‐induced changes (a) in the steady‐state level of endogenous carnosine and conformation of Aβ secondary structure in the different brain regions (cerebral cortex, hippocampus, hypothalamus, pons‐medulla, and cerebellum) and (b) cognitive function. Young (4 months) and aged (18 and 24 months) male albino Wistar rats were treated with carnosine (2.0 μg kg−1 day−1; i.t.) or equivalent volumes of vehicle (saline) for 21 consecutive days and were tested for cognition using 8‐arm radial maze test. Brains were processed to assess the conformational integrity of Aβ plaques using Raman spectroscopy and endogenous levels of carnosine were measured in the brain regions using HPLC. Results indicated that carnosine treatments improved the aging‐induced deficits in cognitive function and reduced the β‐sheets in the secondary structure of Aβ protein, as well as mitigating the reduction in the steady‐state levels of carnosine and spine density in the brain regions examined. These results thus, suggest that carnosine can attenuate the aging‐induced: (a) conformational changes in Aβ secondary structure by reducing the abundance of β‐sheets and reductions in carnosine content in the brain regions and (b) cognitive impairment.

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