Calponin 3 Acts as a Potential Diagnostic and Prognostic Marker and Promotes Glioma Cell Proliferation, Migration, and Invasion

Xie, Yituan; Ding, Wei; Xiang, Yang; Wang, Xiangyu; Yang, Junbao

doi:10.1016/j.wneu.2022.06.136

Cited by 7 publications

(1 citation statement)

References 26 publications

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“…G protein inhibitory α subunit 2 (Gαi2) increases the expression of the NF-κB target gene Sp1 (a transcription factor) through dephosphorylation of the p65 subunit, and at the same time, Sp1 has been confirmed to bind to the Gαi2 promoter region, mediating Gαi2 overexpression [ 64 ]. Calponin 3 (CNN3), melanoma cell adhesion molecule (MCAM, also named CD146), chemerin (also known as retinoic acid receptor responder protein 2 (RARRES2)), retinol-binding protein 1 (RBP1), growth differentiation factor 15 (GDF15), G protein-coupled receptor 17 (GPR17), and cysteamine (2-aminoethanethiol) dioxygenase (ADO) can induce the phosphorylation of p65 to promote GBM cell proliferation [ 65 , 66 , 67 , 68 , 69 , 70 , 71 ].…”

Section: Nf-κb Activation Is Involved In Development and Progression ...mentioning

confidence: 99%

The Recent Research Progress of NF-κB Signaling on the Proliferation, Migration, Invasion, Immune Escape and Drug Resistance of Glioblastoma

Shi

Cui

2023

IJMS

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Glioblastoma multiforme (GBM) is the most common and invasive primary central nervous system tumor in humans, accounting for approximately 45–50% of all primary brain tumors. How to conduct early diagnosis, targeted intervention, and prognostic evaluation of GBM, in order to improve the survival rate of glioblastoma patients, has always been an urgent clinical problem to be solved. Therefore, a deeper understanding of the molecular mechanisms underlying the occurrence and development of GBM is also needed. Like many other cancers, NF-κB signaling plays a crucial role in tumor growth and therapeutic resistance in GBM. However, the molecular mechanism underlying the high activity of NF-κB in GBM remains to be elucidated. This review aims to identify and summarize the NF-κB signaling involved in the recent pathogenesis of GBM, as well as basic therapy for GBM via NF-κB signaling.

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Section: Nf-κb Activation Is Involved In Development and Progression ...mentioning

confidence: 99%

The Recent Research Progress of NF-κB Signaling on the Proliferation, Migration, Invasion, Immune Escape and Drug Resistance of Glioblastoma

Shi

Cui

2023

IJMS

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siRNA-based strategies to combat drug resistance in gastric cancer

Khaleel,

Alshahrani,

Rizaev

et al. 2024

Med Oncol

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Mechanoregulation and function of calponin and transgelin

Rasmussen,

Jin

2024

Biophysics Reviews

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It is well known that chemical energy can be converted to mechanical force in biological systems by motor proteins such as myosin ATPase. It is also broadly observed that constant/static mechanical signals potently induce cellular responses. However, the mechanisms that cells sense and convert the mechanical force into biochemical signals are not well understood. Calponin and transgelin are a family of homologous proteins that participate in the regulation of actin-activated myosin motor activity. An isoform of calponin, calponin 2, has been shown to regulate cytoskeleton-based cell motility functions under mechanical signaling. The expression of the calponin 2 gene and the turnover of calponin 2 protein are both under mechanoregulation. The regulation and function of calponin 2 has physiological and pathological significance, as shown in platelet adhesion, inflammatory arthritis, arterial atherosclerosis, calcific aortic valve disease, post-surgical fibrotic peritoneal adhesion, chronic proteinuria, ovarian insufficiency, and tumor metastasis. The levels of calponin 2 vary in different cell types, reflecting adaptations to specific tissue environments and functional states. The present review focuses on the mechanoregulation of calponin and transgelin family proteins to explore how cells sense steady tension and convert the force signal to biochemical activities. Our objective is to present a current knowledge basis for further investigations to establish the function and mechanisms of calponin and transgelin in cellular mechanoregulation.

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Calponin 3 Acts as a Potential Diagnostic and Prognostic Marker and Promotes Glioma Cell Proliferation, Migration, and Invasion

Cited by 7 publications

References 26 publications

The Recent Research Progress of NF-κB Signaling on the Proliferation, Migration, Invasion, Immune Escape and Drug Resistance of Glioblastoma

The Recent Research Progress of NF-κB Signaling on the Proliferation, Migration, Invasion, Immune Escape and Drug Resistance of Glioblastoma

siRNA-based strategies to combat drug resistance in gastric cancer

Mechanoregulation and function of calponin and transgelin

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