Camel milk attenuates the biochemical and morphological features of diabetic nephropathy: Inhibition of Smad1 and collagen type IV synthesis

Korish, Aida A.; Gader, Abdel Galil Abdel; Korashy, Hesham M.; Al-Drees, Abdul Majeed; Alhaider, Abdulqader A.; Arafah, Maha

doi:10.1016/j.cbi.2015.01.013

Cited by 43 publications

(30 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…SMAD1 , SMAD family member 1, is a signal transducer and transcriptional modulator. Decrease in SMAD1 and collagen type IV provides protection in DN 22 . TGFB1 , transforming growth factor, beta 1, is a multifunctional peptide that regulates proliferation, differentiation and adhesion.…”

Section: Resultsmentioning

confidence: 99%

T2DiACoD: A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders

Rani

Mittal

Pramanik

et al. 2017

Sci Rep

View full text Add to dashboard Cite

We performed integrative analysis of genes associated with type 2 Diabetes Mellitus (T2DM) associated complications by automated text mining with manual curation and also gene expression analysis from Gene Expression Omnibus. They were analysed for pathogenic or protective role, trends, interaction with risk factors, Gene Ontology enrichment and tissue wise differential expression. The database T2DiACoD houses 650 genes, and 34 microRNAs associated with T2DM complications. Seven genes AGER, TNFRSF11B, CRK, PON1, ADIPOQ, CRP and NOS3 are associated with all 5 complications. Several genes are studied in multiple years in all complications with high proportion in cardiovascular (75.8%) and atherosclerosis (51.3%). T2DM Patients’ skeletal muscle tissues showed high fold change in differentially expressed genes. Among the differentially expressed genes, VEGFA is associated with several complications of T2DM. A few genes ACE2, ADCYAP1, HDAC4, NCF1, NFE2L2, OSM, SMAD1, TGFB1, BDNF, SYVN1, TXNIP, CD36, CYP2J2, NLRP3 with details of protective role are catalogued. Obesity is clearly a dominant risk factor interacting with the genes of T2DM complications followed by inflammation, diet and stress to variable extents. This information emerging from the integrative approach used in this work could benefit further therapeutic approaches. The T2DiACoD is available at www.http://t2diacod.igib.res.in/.

show abstract

Section: Resultsmentioning

confidence: 99%

T2DiACoD: A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders

Rani

Mittal

Pramanik

et al. 2017

Sci Rep

View full text Add to dashboard Cite

show abstract

“…However, growing evidence suggests that oxidative damage plays a definitive role in the pathogenesis of DN [3]. Chronic hyperglycemia activates glomerular epithelial cells to produce reactive oxygen species (ROS), as increased cellular glucose induces ROS generation by disturbing the oxidant/ antioxidant balance such as reduction of superoxide dismutase (SOD) activity [26,27]. In addition, over-expression of human cytoplasmic Cu 2+ /Zn 2+ SOD in STZ-induced diabetic mice was found capable of attenuating diabetic renal injury [28].…”

Section: Discussionmentioning

confidence: 99%

Danshen injection ameliorates STZ-induced diabetic nephropathy in association with suppression of oxidative stress, pro-inflammatory factors and fibrosis

Shen²,

Bi³

et al. 2016

International Immunopharmacology

View full text Add to dashboard Cite

“…28,29 Consumption of camel milk is specifically sought as a medication and may have favorable effects on diabetes control and diabetic nephropathy. 30,31 Several region-specific exposures and cultural practices that can affect patients with CKD are under studies such as endemic infectious diseases, local environmental exposures, 32 religious rituals 33 and traditional practices including the use of CAM. This study has explored the specific types and patterns of different CAM practices and their sociodemographic correlates, the patient's perspectives of these practices and their impact on the interaction with the medical system.…”

Section: Discussionmentioning

confidence: 99%