Campaign Against Glossina in the Republic of Central Africa

Finelle, Pierre

doi:10.1016/b978-0-08-011427-9.50296-1

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(Anene, 2001;Kneeland et al, 2012;WHO, 2013). The causative agents of this disease include Trypanosoma congolense (T.congolense), T. vivax and T. brucei brucei in cattle, sheep and goats; T. evansi in horses and camels, and T. simiae in pigs (Finelle, 2002;Grebaut et al, 2009). Amongst these parasites, the subspecies T. b. brucei is acclaimed to be the most virulent in attacking domestic animals because it is covered by a dense protein layer consisting of a single protein called the variable surface glycoprotein (VSG).…”

Section: Introductionmentioning

confidence: 99%

Ameliorative Effects of Trypadim®, Trypamidium® and Novidium® on the Negative Effects on Body Temperature and Serum Chemistry in Wistar Rats Infected With Trypanosoma Brucei Brucei (Federe Strain)

AJAKAIYE¹,

MOHAMMAD²,

MAZADU³

et al. 2022

FUDMAJAAT

View full text Add to dashboard Cite

Effect of intramuscular administration of Trypanocides on body temperature and serum chemistry in Wistar rats infected with Trypanosoma brucei brucei was investigated. 25 Wistar rats with average body weights of 200-240±20 g were randomly divided into five groups. Group A was administered 0.5 mL of normal saline only, while group B was given 0.1 × 106 of T. brucei brucei only. Group C, D and E were inoculated with the same dose of the parasite as in group B and in addition, they were intramuscularly administered with 3.5 mg/kg b.w. of Trypadim® (Diminazene di-aceturate),1 mg/kg b.w. of Trypamidium® (Isometamidium chloride) and 1 mg/kg b.w. of Novidium® (Homidium chloride), respectively. Body temperature increased consistently in all groups except group A. However, there was a significant (p<0.05) difference in all treated groups compared to group B on 28day post-infection (DPI). All serum indicators increased significantly (p<0.05) in group B when compared to all other groups. Values observed for creatinine in all treated groups was only significantly (p<0.05) higher in group E when compared to group A. In conclusion, administered trypanocidal drugs possess anti-pyrexia activity and could off-set the negative effect of T.brucei.brucei on the measured serum chemistry in Wistar rats.

show abstract

Section: Introductionmentioning

confidence: 99%