Camphor ingestion for abortion (case report)

Rabl, Walter; Katzgraber, F.; Steinlechner, Martin

doi:10.1016/s0379-0738(97)00099-6

Cited by 37 publications

(14 citation statements)

References 5 publications

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“…Camphor accounted for about 1.5 g/100 g of this plant [17]. Rabl and coworkers have reported that camphor crosses the placenta and may lead to abortion [18]. In another study, Linjawi reported that camphor induces significant structural changes on uterus of pregnant rats [19].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Cytotoxicity and Antifertility Effect ofArtemisia kopetdaghensis

Oliaee

Boroushaki

Oliaee

et al. 2014

Advances in Pharmacological Sciences

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To date, there is no report on safety of Artemisia Kopetdaghensis. This study aimed to determine the possible undesirable effects of A. Kopetdaghensis on reproduction of female rats. The pregnant rats were treated (i.p.) with vehicle or 200 and 400 mg/kg of A. Kopetdaghensis hydroalcoholic extract from the 2nd to 8th day of pregnancy. Then, number and weight of neonates, duration of pregnancy, and percent of dead fetuses were determined. Also, cytotoxicity of this plant was tested using fibroblast (L929) and ovary (Cho) cell lines. The A. Kopetdaghensis had no significant effect on duration of pregnancy, average number of neonates, and weight of neonates. However, administration of 200 and 400 mg/kg of the extract led to 30 and 44% abortion in animals, respectively. The extract at concentrations ≥200 μg/mL significantly (P < 0.001) inhibited the proliferation of L929 fibroblast cells. Regarding the Cho cells, the extract induced toxicity only at concentration of 800 μg/mL (P < 0.01). Our results showed that continuous consumption of A. Kopetdaghensis in pregnancy may increase the risk of abortion and also may have toxic effect on some cells.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Cytotoxicity and Antifertility Effect ofArtemisia kopetdaghensis

Oliaee

Boroushaki

Oliaee

et al. 2014

Advances in Pharmacological Sciences

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“…There were four cases of solid camphor ingestion reported in three articles (17,54,55). Toxicity, characterized by hallucinations, agitation, anxiety and tachycardia occurred in two young adult men following the ingestion of 6-10 g (17).…”

Section: Acute Camphor Ingestions In Patients 6 Years Of Age or Oldermentioning

confidence: 99%

“…Toxicity, characterized by hallucinations, agitation, anxiety and tachycardia occurred in two young adult men following the ingestion of 6-10 g (17). A 16-year-old pregnant girl developed nausea, dizziness, cramping, and shortness of breath following the ingestion of 30 g of camphor dissolved in red wine as an abortifacient (55). The lowest dose associated with severe toxicity with convulsions was 3 drams of camphor.…”

Section: Acute Camphor Ingestions In Patients 6 Years Of Age or Oldermentioning

confidence: 99%

Camphor Poisoning: an Evidence-Based Practice Guideline for Out-of-Hospital Management

Manoguerra

Erdman

Wax

et al. 2006

Clinical Toxicology

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“…5 However, camphor ingestion may lead to abortion and/or a death of the fetus because camphor crosses the placenta and fetuses lack the enzymes needed to hydroxylate and conjugate with glucuronic acid. 6 Animal studies: Carcinogenicity tests in animals have been negative. Neuronal necrosis produced experimentally in mice by administration of multiple doses.…”

Section: Introductionmentioning

confidence: 99%

Toxopathological effects of camphor on some organs of female rats

Al-Muswie

Alomer

Al-Fartosi

2017

IMJ

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Objective The effects of camphor in the histological change on some organs of female rats. In Iraq, camphor in the form of tablets was added to wash dead bodies, and thus putting washers in great risk, especially female washers. Though, the literature concerning its histological toxicity has not been documented. It has long been used in dead bodies washed. In our study, we used high dose of camphor to investigate the effect of camphor in histological change on some organs. Methods The rats were divided into three groups (n = 6), the first group (A) was a control group and treated with distilled water, the second and third groups (B and C) treated with 50 mg camphor/kg and 75 mg camphor/kg, respectively. At the end of the first month of treatment, animals were anesthetized; liver, kidney, spleen, and ovary were removed for serial sections, and histological staining.Results The results showed vaculation in hepatocytes, and infiltration of inflammatory cells loss of most of the architecture and cell boundaries in liver of group (B), while in group (C), there was congestion in area of Portia, detachment of some hepatocytes, and inflammatory cells. Kidney of group B showed edematous glomerulus, glomerular lobulation, and increased number of nuclei. Also, there were swollen glomerulus, increase number of nuclei, and congestion of blood cells in kidney of group C. Spleen of groups B and C revealed non-active lymphoid tissue and degenerated lymphocytes cells, congestion in lymphoid tissue, and depletion of white pulp mainly neutrophils and macrophage. Also, the results showed congestion in follicles (B) and hemorrhage (C), detachment in oocytes in treatment groups compared with control group. Conclusions The oral administration of varying concentration of camphor solution to the animal rat has a cytotoxic effect on organs, such as the liver, kidney, spleen, and ovary.

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Camphor ingestion for abortion (case report)

Cited by 37 publications

References 5 publications

Evaluation of Cytotoxicity and Antifertility Effect ofArtemisia kopetdaghensis

Evaluation of Cytotoxicity and Antifertility Effect ofArtemisia kopetdaghensis

Camphor Poisoning: an Evidence-Based Practice Guideline for Out-of-Hospital Management

Toxopathological effects of camphor on some organs of female rats

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