Camphor poisoning

Kppel, C.; Tenczer, J.; Schirop, Th.; Ibe, K.

doi:10.1007/bf00279325

Cited by 26 publications

(7 citation statements)

References 9 publications

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“…Moreover, the same ionic structure should be present initially in the mixed ion population produced by classical electron ionization (EI) of dextromethorphan (assuming the lone pair of electrons on the nitrogen center has a relatively large ionization cross section). Indeed, the EI spectrum of dextromethorphan features a prominent ion of m/z 150 (Scheme ) 14. Moreover, we recently performed a selective low‐energy charge exchange reaction (LECHER) experiment on dextromethorphan to produce m/z 271, and upon MS/MS of this species, produced m/z 15015 We were recently able to produce a LECHER MS 6 result for m/z 271 using a modern, bench‐top ion trap with internal ionization and low pressure CI (unpublished results).This experiment will be a useful paradigm for investigating structures of switched, radical ions.…”

Section: Resultsmentioning

confidence: 99%

Ion trap MSn genealogical mapping?approaches for structure elucidation of novel products of consecutive fragmentations of morphinans

Strife

Robosky

Garrett

et al. 2000

Rapid Commun. Mass Spectrom.

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The analysis of data within multi-generational, genealogical, electrospray ionization/MS(n) fragmentation maps is discussed in reference to the structure elucidation of morphinans, an important class of pharmacological compounds. Various general approaches to separate and understand observed processes are discussed. These include: (1) Simple synthetic schemes incorporating deuterium and (13)C into morphinans to study later-generation, O-methyl group migration; (2) labeling to understand 'intense' signals for even-electron to odd-electron ion 'switching' events; (3) gas phase 'synthesis' of proposed MS(3) ions via an independent route, using chemical ionization (CI) MS/MS of naphthalenes and analysis via a bench-top El/Cl ion trap; (4) a useful synthetic paradigm for generating proposed carbonium ion structures at MS(4) via electrospray ionization (ESI) of easily synthesized amines; (5) the analysis of an oxidation product and correlation of MS(n) data of a switched, odd-electron species with electron ionization and low-pressure, low-energy charge exchange data; and (6) a new way of summarizing MS(n) data. Copyright -Copyright 2000 John Wiley & Sons, Ltd.

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Section: Resultsmentioning

confidence: 99%

Ion trap MSn genealogical mapping?approaches for structure elucidation of novel products of consecutive fragmentations of morphinans

Strife

Robosky

Garrett

et al. 2000

Rapid Commun. Mass Spectrom.

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“…C. M3 which was tentatively characterized as 2,5‐bornanedione, have been identified in human urine after taking camphor .They also described hydroxylation and oxidation of camphor at C‐3, C‐5, C‐8, and C‐9 in human body, while ours at C‐5 and C‐10. Differences in metabolic enzymes between humans and rats might be the reason of the conflicting results.…”

Section: Resultsmentioning

confidence: 96%

Vortex‐ultrasound‐assisted dispersive liquid–liquid microextraction coupled with gas chromatography–mass spectrometry for the analysis of volatile bioactive components and comparative pharmacokinetic study of the herb–herb interactions in Guanxin Shutong Capsule

Gao

et al. 2017

J of Separation Science

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Guanxin Shutong Capsule, an effective traditional Chinese medicine, is widely used for coronary heart disease clinically. Volatile components are one of its important bioactive constituents. To better understand the material basis for the therapeutic effects, the components of Guanxin Shutong Capsule absorbed into the blood and their metabolites were identified based on gas chromatography with mass spectrometry coupled with vortex-ultrasound-assisted dispersive liquid-liquid microextraction. As a result, three prototypes and 15 metabolites were identified or tentatively characterized in rat plasma. Subsequently, a pharmacokinetic study was carried out to monitor the concentrations of the main bioactive constituents and metabolites (isoborneol, borneol, eugenol, and camphor) by gas chromatography with mass spectrometry in rat plasma following oral administration of single herb extract and different combinations of herbs in this prescription. Compared to other groups, a statistically significant difference of the pharmacokinetic properties was obtained when the total complex prescription was administered, indicating possible drug-drug interactions among the complex ingredients of Guanxin Shutong Capsule. These findings provided an experimental basis concerning the clinical application and medicinal efficacy of Guanxin Shutong Capsule in the treatment of coronary heart disease.

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“…Camphor can cause spasms, confusion, irritation, and neuromuscular hyperactivity. The lethal dose ranges from 50 to 500 mg/kg . The toxic level of camphor concentration in the blood ranges from 0.3 to 0.4 mg/L, and the lethal concentration is more than 1 mg/L .…”

Section: Discussionmentioning

confidence: 99%

Fatal Ingestion of Chlumsky Disinfectant Solution

Handlos

Uvíra

Marecová

et al. 2017

Journal of Forensic Sciences

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A 32-year-old pregnant woman in the 25th week of pregnancy underwent oral glucose tolerance screening at the diabetologist's. Later that day, she was found dead in her apartment possibly poisoned with Chlumsky disinfectant solution (solutio phenoli camphorata). An autopsy revealed chemical burns in the digestive system. The lungs and the brain showed signs of severe edema. The blood of the woman and fetus was analyzed using gas chromatography with mass spectrometry and revealed phenol, its metabolites (phenyl glucuronide and phenyl sulfate) and camphor. No ethanol was found in the blood samples. Both phenol and camphor are contained in Chlumsky disinfectant solution, which is used for disinfecting surgical equipment in healthcare facilities. Further investigation revealed that the deceased woman had been accidentally administered a disinfectant instead of a glucose solution by the nurse, which resulted in acute intoxication followed by the death of the pregnant woman and the fetus.

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Camphor poisoning

Cited by 26 publications

References 9 publications

Ion trap MSn genealogical mapping?approaches for structure elucidation of novel products of consecutive fragmentations of morphinans

Ion trap MSn genealogical mapping?approaches for structure elucidation of novel products of consecutive fragmentations of morphinans

Vortex‐ultrasound‐assisted dispersive liquid–liquid microextraction coupled with gas chromatography–mass spectrometry for the analysis of volatile bioactive components and comparative pharmacokinetic study of the herb–herb interactions in Guanxin Shutong Capsule

Fatal Ingestion of Chlumsky Disinfectant Solution

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