Camptothecin-loaded films for the prevention of postsurgical adhesions

Abstract

CPT loaded films inhibited the formation of adhesions in the rat cecal sidewall abrasion model. HA crosslinked with 2 mM carbodiimide and containing 20% w/w glycerol and 0.6, 2.5 or 7.5% w/w CPT are flexible, mucoadhesive, biocompatible controlled release films that can be used to prevent adhesion formation.

Surface Treatment of Flexor Tendon Autografts with Carbodiimide-Derivatized Hyaluronic Acid<sbt aid="1047845">An in Vivo Canine Model</sbt>

“…The modification of hyaluronic acid with use of the carbodiimide (EDC) reaction to create new biopolymers, crosslinking with other biological molecules such as collagen, has been recently and widely investigated for applications such as anti-adhesion membranes 40,57 and biodegradable scaffolds 58,59 , for tissue regeneration, or as timed-release drug-delivery vehicles 60,61 . However, to our knowledge, we are the first to report the use of cd-HA by direct bonding to the tendon surface to improve flexor tendon grafting in vivo.…”

The prevention of peritendinous adhesions by a phospholipid polymer hydrogel formed in situ by spontaneous intermolecular interactions

“…In addition, to analyze the extent of adhesion formation, we evenly divided the tendon surface into 40 areas and used two evaluation parameters, the adhesion score and adhesion rate, for this purpose. The adhesion score was used to categorize the severity of adhesion at a particular area into grade 1-5 on the basis of the surgical findings: grade 1, no adhesion; grade 2, adhesion can be separated by blunt dissection alone; grade 3, sharp dissection is required to separate less than or equal to 50% of the adhesion area; grade 4, sharp dissection is required to separate 51-97.5% of the adhesion area; and grade 5, sharp dissection is required to separate more than 97.5% of the adhesion area [31]. The adhesion rate was used to quantify the severity of adhesion of the tendon as a whole.…”

Cross-Linked Hyaluronic Acid Films to Reduce Intra-Abdominal Postsurgical Adhesions in an Experimental Model

“…Cross-linking of HA could be a strategy to enhance its stability and thus increase the residence time of HA inside the abdomen after deployment [22,23]. In some studies, solid HA films were formulated from either pure HA [24] or by blending it with other biologically derived materials [25]. Furthermore, some cross-linked HA films have demonstrated cell antiadhesion in vitro due to the hydrophobic, polyanionic surface characteristics of the film prepared [22,26].…”