We investigated phospholipid polymer hydrogels containing Fe3+ ions (PMA/PMB/Fe
hydrogel) for their use as antiadhesive materials in the healing tissues. These hydrogels were
prepared from the aqueous solutions of poly(2-methacryloyloxyethyl phosphorylcholine (MPC)-comethacrylic
acid) (PMA) and poly(MPC-co-n-butyl methacrylate) (PMB). The PMA/PMB hydrogel
is formed by the intermolecular interactions between PMA and PMB, and it reversibly dissociates
under physiological conditions. The addition of Fe3+ ions could control the gelation time and the
dissociation time. Mechanical properties such as the gelation time and viscoelastic properties can be
controlled by the FeCl3 concentration. With regard to biocompatibility, no evidence of
inflammation was observed in vivo. Therefore, the PMA/PMB/Fe hydrogel has a potential to be
used as an antiadhesive material.
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