Camptothecin-loaded holmium ferrite nanocarrier. Expanded activity on breast cancer cells

Kaliyamoorthi, Kiruthiga; Ramasamy, Sivaraj; Pillai, Archana Sumohan; Alexander, Aleyamma; Arivarasu, Anitha; Enoch, Israel V.M.V.

doi:10.1016/j.matlet.2020.129164

Cited by 18 publications

(5 citation statements)

References 19 publications

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“…The application of camptothecin in cancer treatment is limited due to its poor water solubility. However, modification with nanotechnology makes it feasible to be used in cancer therapy [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

Nanoparticle-Encapsulated Camptothecin: Epigenetic Modulation in DNA Repair Mechanisms in Colon Cancer Cells

et al. 2021

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Molecular crosstalk between the cellular epigenome and genome converge as a synergistic driver of oncogenic transformations. Besides other pathways, epigenetic regulatory circuits exert their effect towards cancer progression through the induction of DNA repair deficiencies. We explored this mechanism using a camptothecin encapsulated in β-cyclodextrin–EDTA–Fe3O4 nanoparticles (CPT-CEF)-treated HT29 cells model. We previously demonstrated that CPT-CEF treatment of HT29 cells effectively induces apoptosis and cell cycle arrest, stalling cancer progression. A comparative transcriptome analysis of CPT-CEF-treated versus untreated HT29 cells indicated that genes controlling mismatch repair, base excision repair, and homologues recombination were downregulated in these cancer cells. Our study demonstrated that treatment with CPT-CEF alleviated this repression. We observed that CPT-CEF exerts its effect by possibly affecting the DNA repair mechanism through epigenetic modulation involving genes of HMGB1, APEX1, and POLE3. Hence, we propose that CPT-CEF could be a DNA repair modulator that harnesses the cell’s epigenomic plasticity to amend DNA repair deficiencies in cancer cells.

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Section: Resultsmentioning

confidence: 99%

Nanoparticle-Encapsulated Camptothecin: Epigenetic Modulation in DNA Repair Mechanisms in Colon Cancer Cells

et al. 2021

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“…For example, the holmium ferrite nanoparticles coated with cyclodextrin and polyethylene glycol loaded with camptothecin, an anticancer drug revealed anticancer potential 79.42% when tested at 250 μg mL −1 . 53 A similar nanocarrier system based on holmium ferrite was described for the potential treatment of human glioma cancer. 54 The anticancer mechanism of the rare earth lanthanides is mostly ascribed to the oxidative stress generated by the reactive oxygen species, retarding the calcium transport, direct interaction with cellular organelle and DNA, endoplasmic reticulum stress, activating the mitogen-activated protein kinase (MAPK) etc.…”

Section: Discussionmentioning

confidence: 99%

Phyto-fabrication of ultrafine nanoscale holmium oxide HT-Ho₂O₃ NPs and their biomedical potential

Ahmed Mohamed,

Khalil,

Hkiri

et al. 2023

RSC Adv.

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“…In addition, the release of the drug is preferred to be sustained and slow. 31 Therefore, the drug loading and the drug-release kinetics were investigated in vitro. The experimental procedures have been elaborated in the methods section.…”

Section: Drug-loading and Releasementioning

confidence: 99%

Camptothecin-Carrying Cuco2s4 Nanoparticles: Sustained Drug Release And Anticancer Activity

Pillai

Alexander

Manikantan

et al. 2021

Preprint

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Nanocarriers of anticancer drugs are delicately designed with precision addition at every attempt. In this paper, we report CuCo2S4 nanoparticles that show light-absorption in the NIR-II wavelength range and possess magnetic characteristics. The synthesized nanoparticles are characterized employing XRD, SEM, DLS, TGA, and XPS methods. The nanoparticles form a composite with biocompatible polymeric β-cyclodextrin. The nanoparticles possess a band gap energy of 2.25 eV. The magnetic property arises due to the cobalt-incorporation in the nanoparticles. The anticancer drug, camptothecin, is loaded in the nanocarrier with an 89% adsorption efficiency. The in vitro release of the drug occurs in a sustained fashion. Further, the in vitro anticancer potential of the nanocarrier is examined on breast cancer (MDA=MB-231) cell lines and the activities of the free- and the drug-loaded nanocarrier are compared. The cobalt-containing copper sulfide nanoparticle-poly-β-cyclodextrin composite works as a promising nanocarrier of camptothecin.

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Camptothecin-loaded holmium ferrite nanocarrier. Expanded activity on breast cancer cells

Cited by 18 publications

References 19 publications

Nanoparticle-Encapsulated Camptothecin: Epigenetic Modulation in DNA Repair Mechanisms in Colon Cancer Cells

Nanoparticle-Encapsulated Camptothecin: Epigenetic Modulation in DNA Repair Mechanisms in Colon Cancer Cells

Phyto-fabrication of ultrafine nanoscale holmium oxide HT-Ho₂O₃ NPs and their biomedical potential

Camptothecin-Carrying Cuco2s4 Nanoparticles: Sustained Drug Release And Anticancer Activity

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Camptothecin-loaded holmium ferrite nanocarrier. Expanded activity on breast cancer cells

Cited by 18 publications

References 19 publications

Nanoparticle-Encapsulated Camptothecin: Epigenetic Modulation in DNA Repair Mechanisms in Colon Cancer Cells

Nanoparticle-Encapsulated Camptothecin: Epigenetic Modulation in DNA Repair Mechanisms in Colon Cancer Cells

Phyto-fabrication of ultrafine nanoscale holmium oxide HT-Ho2O3 NPs and their biomedical potential

Camptothecin-Carrying Cuco2s4 Nanoparticles: Sustained Drug Release And Anticancer Activity

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Phyto-fabrication of ultrafine nanoscale holmium oxide HT-Ho₂O₃ NPs and their biomedical potential