Campylobacter fetus bacteremia in a young healthy adult transmitted by khat chewing

Kohlitz, Patrick; Chaudhary, Preeti; Hegazy, Housam

doi:10.1016/j.jinf.2011.11.020

Cited by 16 publications

(8 citation statements)

References 14 publications

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“…However, in this report we describe a C. fetus infection in an immunocompetent patient who apparently was not exposed to any obvious source. Similar cases have been reported previously (Zonios et al, 2005;Mart ınez-Balzano et al, 2013).…”

Section: Campylobacter Iguaniorum Strain 1485esupporting

confidence: 91%

“…The dwells in the Amazon region do not have walls, and domestic animals roam freely in their interior and can potentially contaminate food with secretions. It is worth mentioning that vegetables have been also implicated in human infection previously (Mart ınez-Balzano et al, 2013). Finally, it is possible that the patient inadvertently ingested food which contained raw milk or other uncooked animal products.…”

Section: Campylobacter Iguaniorum Strain 1485ementioning

confidence: 99%

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Campylobacter fetus Bacteremia in a Healthy Patient Returning from a Trip to the Ecuadorian Amazonia

Chávez

Barrera

León³

et al. 2016

Zoonoses and Public Health

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Campylobacter fetus is an opportunistic pathogen which causes bacteremia and other invasive infections in immunocompromised patients who have been exposed to livestock or ingested animal products (uncooked meat or unpasteurized milk). The present report describes a C. fetus infection in a healthy adult (immunocompetent) who returned from a visit to the Ecuadorian Amazonia and who did not report exposure to the typical sources of infection.

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Section: Campylobacter Iguaniorum Strain 1485esupporting

confidence: 91%

Section: Campylobacter Iguaniorum Strain 1485ementioning

confidence: 99%

Campylobacter fetus Bacteremia in a Healthy Patient Returning from a Trip to the Ecuadorian Amazonia

Chávez

Barrera

León³

et al. 2016

Zoonoses and Public Health

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“…Overall, 82 % reported the presence of skin or mucosal lesions at the time of infection. Whether these observations are pointing to a possible route of infection, as suggested previously [ 46 ], remains to be shown.…”

Section: Discussionmentioning

confidence: 58%

Clinical and epidemiological analysis of Campylobacter fetus subsp. fetus infections in humans and comparative genetic analysis with strains isolated from cattle

et al. 2016

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BackgroundCampylobacter fetus subspecies fetus (CFF) is an important pathogen for both cattle and humans. We performed a systematic epidemiological and clinical study of patients and evaluated the genetic relatedness of 17 human and 17 bovine CFF isolates by using different genotyping methods. In addition, the serotype, the dissemination of the genomic island containing a type IV secretion system (T4SS) and resistance determinants for tetracycline and streptomycin were also evaluated.MethodsThe isolates from patients diagnosed with CFF infection as well as those from faecal samples of healthy calves were genotyped using pulsed-field gel electrophoresis (PFGE), multilocus sequence typing (MLST), as well as single locus sequence typing (SLST) targeting cmp1 and cmp2 genes encoding two major outer membrane proteins in CFF. The presence of the genomic island and identification of serotype was determined by PCRs targeting genes of the T4SS and the sap locus, respectively. Tetracycline and streptomycin resistance phenotypes were determined by minimal inhibitory concentration. Clinical data obtained from medical records and laboratory data were supplemented by data obtained via telephone interviews with the patients and treating physicians.ResultsPFGE analysis defined two major clusters; cluster A containing 16 bovine (80 %) isolates and cluster B containing 13 human (92 %) isolates, suggesting a host preference. Further genotypic analysis using MLST, SLST as well as sap and T4SS PCR showed the presence of genotypically identical isolates in cattle and humans. The low diversity observed within the cmp alleles of CFF corroborates the clonal nature of this pathogen. The genomic island containing the tetracycline and streptomycin resistance determinants was found in 55 % of the isolates in cluster A and correlated with phenotypic antibiotic resistance.ConclusionsMost human and bovine isolates were separated on two phylogenetic clusters. However, several human and bovine isolates were identical by diverse genotyping methods, indicating a possible link between strains from these two hosts.

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“…To our knowledge, no reported C. fetus infection manifested as meningitis and endocarditis, but endocarditis was excluded by echocardiography for only 2 previous meningitis cases (5,11). These two infectious loci are probably secondary to bacteremia.…”

mentioning

confidence: 96%

“…Unfortunately, stool cultures to identify C. fetus were not done in Lebanon. Some C. fetus infection case reports have described indirect transmission: through raw milk (3), insufficiently cooked chicken, beef, or sheep meat or liver (4), or khat chewing (5). Several cases of inoculation Case Report via a peritoneal dialysis catheter (6) or in slaughterhouse workers (7) have been published.…”

mentioning

confidence: 99%

Meningitis and Endocarditis Caused by Campylobacter fetus after Raw-Liver Ingestion

et al. 2013

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Campylobacter fetus bacteremia in a young healthy adult transmitted by khat chewing

Cited by 16 publications

References 14 publications

Campylobacter fetus Bacteremia in a Healthy Patient Returning from a Trip to the Ecuadorian Amazonia

Campylobacter fetus Bacteremia in a Healthy Patient Returning from a Trip to the Ecuadorian Amazonia

Clinical and epidemiological analysis of Campylobacter fetus subsp. fetus infections in humans and comparative genetic analysis with strains isolated from cattle

Meningitis and Endocarditis Caused by Campylobacter fetus after Raw-Liver Ingestion

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