Campylobacter fetus infections

Cypierre, A.; Denès, E.; Barraud, Olivier; Jamilloux, Yvan; Jacques, J.; Durox, H.; Pinet, P.; Weinbreck, P.

doi:10.1016/j.medmal.2014.02.001

Cited by 14 publications

(12 citation statements)

References 22 publications

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“…A minority of patients in our study were immunosuppressed or immunocompromised, and impairment of the immunological response might favour the occurrence of CFF infection, as does diabetes mellitus and alcohol abuse. Furthermore CFF has a predilection for spreading to sites of implanted medical devices [ 3 , 6 , 7 , 9 , 11 ]. In contrast to one published report, antibiotic therapy alone failed to eradicate CFF of joint prosthesis infections in our cases.…”

Section: Discussionmentioning

confidence: 99%

Clinical and epidemiological analysis of Campylobacter fetus subsp. fetus infections in humans and comparative genetic analysis with strains isolated from cattle

et al. 2016

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BackgroundCampylobacter fetus subspecies fetus (CFF) is an important pathogen for both cattle and humans. We performed a systematic epidemiological and clinical study of patients and evaluated the genetic relatedness of 17 human and 17 bovine CFF isolates by using different genotyping methods. In addition, the serotype, the dissemination of the genomic island containing a type IV secretion system (T4SS) and resistance determinants for tetracycline and streptomycin were also evaluated.MethodsThe isolates from patients diagnosed with CFF infection as well as those from faecal samples of healthy calves were genotyped using pulsed-field gel electrophoresis (PFGE), multilocus sequence typing (MLST), as well as single locus sequence typing (SLST) targeting cmp1 and cmp2 genes encoding two major outer membrane proteins in CFF. The presence of the genomic island and identification of serotype was determined by PCRs targeting genes of the T4SS and the sap locus, respectively. Tetracycline and streptomycin resistance phenotypes were determined by minimal inhibitory concentration. Clinical data obtained from medical records and laboratory data were supplemented by data obtained via telephone interviews with the patients and treating physicians.ResultsPFGE analysis defined two major clusters; cluster A containing 16 bovine (80 %) isolates and cluster B containing 13 human (92 %) isolates, suggesting a host preference. Further genotypic analysis using MLST, SLST as well as sap and T4SS PCR showed the presence of genotypically identical isolates in cattle and humans. The low diversity observed within the cmp alleles of CFF corroborates the clonal nature of this pathogen. The genomic island containing the tetracycline and streptomycin resistance determinants was found in 55 % of the isolates in cluster A and correlated with phenotypic antibiotic resistance.ConclusionsMost human and bovine isolates were separated on two phylogenetic clusters. However, several human and bovine isolates were identical by diverse genotyping methods, indicating a possible link between strains from these two hosts.

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Section: Discussionmentioning

confidence: 99%

Clinical and epidemiological analysis of Campylobacter fetus subsp. fetus infections in humans and comparative genetic analysis with strains isolated from cattle

et al. 2016

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“…Biochemical identification and MALDI-TOF is used to identify C. fetus. 15 In conclusion, despite C. fetus infections are low, and case reports are rare in current literature, the actual incidence of Campylobacter infections has not been known due to its rare occasion and the specific growth conditions. For this reason, the possibility that infections can occur with these bacteria should not be overlooked in the clinical laboratory.…”

Section: Discussionmentioning

confidence: 92%

“…Unlike C. jejuni, C. fetus rarely causes diarrhea, but it is known to cause isolated bacteremia. 15 A limitation of our study is the absence of the molecular analysis in the bacteriological identification. Correct identification needs molecular analysis, but we could not use molecular methods for a single case because of the high cost.…”

Section: Discussionmentioning

confidence: 97%

Campylobacter fetus subsp. fetus bacteremia in a patient with myelodysplastic syndrome: A case report

Dagi¹

2014

Jmid

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Campylobacter fetus is an important pathogen of extra intestinal infections in patients with immunodeficiency. A case of Campylobacter fetus subsp. fetus bacteremia in a patient with myelodysplastic syndrome was presented in this study.A 78-year-old woman with myelodysplastic syndrome was admitted to the emergency due to chest pain and dyspnea. A diagnosis of pneumonia was made, and blood, throat, and urine samples were obtained for microbiological tests. Trimethoprim-sulfamethoxazole and piperacillin-tazobactam were empirically initiated. C. fetus subsp. fetus was isolated from blood cultures and clarithromycin was added. The patient responded an overall 21-day antimicrobial treatment. Because repeated blood cultures were negative, and her general condition improved, upon that she was discharged from the hospital.In conclusion, the incidence of C. fetus infections was low, and case reports are rare in current literature in Turkey. The infections can occur with these bacteria should not be overlooked in the clinical laboratory.

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“…C. fetus infections are rare and occur in patients presenting with underlying immune deficiencies, malignancy, diabetes mellitus, chronic liver disease, elderly age or under immunosuppressive treatment [ 3 ]. They cause bacteremia which may be related or not to secondary localizations.…”

Section: Introductionmentioning

confidence: 99%

“…They cause bacteremia which may be related or not to secondary localizations. When metastatic infection is present, the most common localizations are the vascular system (aneurysms or vascular prosthesis infections) or cutaneous [ 3 ]. The protein surface layer of this microorganism allows it to evade opsonization, leading to easier invasion of extraintestinal infectious focus with particular tropism for the human vascular endothelium due to bacterial surface receptors [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Campylobacter fetus Cellulitis

Bastos¹,

Gomes²,

Pocinho³

et al. 2023

Cureus

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Campylobacter fetus , a bacteria of the Campylobacter genus that are a group of bacteria known to cause intestinal infections, is a particular microbial agent due to its most common presentation being as a non-intestinal systemic infection and rarely as a focal infection, most frequently cellulitis. C. fetus ’s main reservoirs are cattle and sheep. Humans are usually infected by consuming raw milk and/or meat. Infection in humans is rare and generally related to immune deficiencies, malignancy, chronic liver disease, diabetes mellitus and elderly age, among other factors. Diagnosis is usually achieved by blood cultures due to the lack of focalized signs/symptoms and the pathogen’s endovascular tropism. The authors present a case of cellulitis due to Campylobacter fetus , a microbial agent that affects susceptible patients with a mortality rate of up to 14%. We aim to emphasize the importance of potential bacterial seeding sites secondary to bacteremia given the agent tropism for vascular tissue. The medical diagnosis was performed by the identification of bacteria in blood cultures. Campylobacter spp. infections are more frequently related to undercooked poultry or meat, but in this case, the consumption of fresh cheese was considered the most likely source of infection. A literature review showed that, in patients with previous antibiotic cycles, a combination of carbapenem and gentamicin had better outcomes and lower relapse rates. Due to typical surface antigenic variation, immune control may not be attainable and may account for relapsing infections, even after appropriate therapy. The duration of treatment has yet to be well established. Based on other reported cases, we considered a four-week treatment to be sufficient, given clinical improvement and absence of recurrence in the follow-up time.

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Campylobacter fetus infections

Cited by 14 publications

References 22 publications

Clinical and epidemiological analysis of Campylobacter fetus subsp. fetus infections in humans and comparative genetic analysis with strains isolated from cattle

Clinical and epidemiological analysis of Campylobacter fetus subsp. fetus infections in humans and comparative genetic analysis with strains isolated from cattle

Campylobacter fetus subsp. fetus bacteremia in a patient with myelodysplastic syndrome: A case report

Campylobacter fetus Cellulitis

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