Campylobacter infection in adult patients with primary antibody deficiency

Genetic stability of Campylobacter coli in patients with primary antibody deficiencies

“…In summary, in our patients, all C. coli isolates were genetically identical, suggesting a long-lasting latent infection and not a reinfection nor colonization with different strains. 1 Differently from Dion et al, 1 we hypothesized that inability to mount a specific immune response would account for colonization and infection and for the genetic stability of C. coli. As we have previously suggested, 1 periodic stool cultures with highly sensitive techniques should be performed in PAD.…”

Renal Abscess and Recurrent Bacteremia Caused by Campylobacter Infection in an Adult With Common Variable Immunodeficiency

“…Bacteremia is detected in less than 1% of patients, occurring more frequently in immunocompromised patients, in which the bacterial translocation process is favored, facilitating the passage of bacteria from the intestinal mucosa to the bloodstream [ 1 ]. In patients with PAD, bacteremia and extradigestive localizations are more frequent (25% versus 0.15%-2% and 22% versus 7%, respectively) [ 4 , 5 ], and the recurrence rate is higher (42%) compared with 1.2% in the general population [ 4 , 6 ]. This may lead to repeated hospitalizations and impaired quality of life.…”

“…Despite frequent hospitalizations, the overall prognosis is good, as described in one series where, in 45 patients with 97 episodes of Campylobacter infection, one death occurred [ 4 ]. In this study, it is suggested that reinfection is more likely than persistent colonization since the molecular profiles of strains from patients with recurrent infections were all different, although colonization with multiple strains cannot be excluded [ 4 ]. Campylobacter infection in patients with CVID also tends to be more resistant to therapy when compared to healthy individuals [ 4 , 7 ].…”

“…In this study, it is suggested that reinfection is more likely than persistent colonization since the molecular profiles of strains from patients with recurrent infections were all different, although colonization with multiple strains cannot be excluded [ 4 ]. Campylobacter infection in patients with CVID also tends to be more resistant to therapy when compared to healthy individuals [ 4 , 7 ]. We report the clinical case of an immunocompromised female with a previously undescribed complication of Campylobacter jejuni infection - renal abscess - and recurrent Campylobacter bacteremia that is difficult to manage, with the need of multiple antibiotic treatments, human IV immunoglobulin (IVIg) adjustments, and secondary prophylactic antibiotherapy to prevent recurrence.…”

Primary Immunodeficiencies and Non Malignant Hematologic Disease Associated with Disorders of Hepatic Vessels

“…It is the most frequent form of clinically significant primary immune deficiency, affecting between 1/25000 to 1/500000 of the population. CVID patients are highly susceptible to respiratory infections due to encapsulated bacteria and are also prone to intestinal infections due, among others, to Giardia, Campylobacter, Salmonella or Norovirus [3][4][5]. CVID patients have a tendency to develop a range of associated non-infectious complications.…”