Campylobacter jejuni infection in Guillain-Barré syndrome: A prospective case control study in a tertiary care hospital

Sharma, Avinash; Lal, Vivek; Modi, Manish; Vaishnavi, Chetana; Prabhakar, Sudesh

doi:10.4103/0028-3886.86547

Cited by 19 publications

(10 citation statements)

References 16 publications

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“…Winter predominance (484 (41.50%) patients) of occurrence of illness was noted in our study [ 23 ] followed by summer/pre-monsoon (242 (20.75%) patients) even though it was considered that GBS is sporadic without seasonal preference [ 13 ], [ 22 ]. Our observation differs from studies by Kaur et al [ 24 ], Sharma et al who reported a peak incidence between June–July and Sept–October [ 25 ] and Sriganesh K et al in 2013, who reported increased occurrence of GBS during the months of June to August and December to February [ 26 ]. In many studies, patients admitted with predisposing or associated infection constituted 40–70% of patients [ 2 ], [ 22 ], [ 27 ].…”

Section: Discussioncontrasting

confidence: 99%

Guillain-Barré syndrome: clinical profile and management

Sudulagunta

Sodalagunta²,

Sepehrar

et al. 2015

GMS German Medical Science; 13:Doc16

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Section: Discussioncontrasting

confidence: 99%

Guillain-Barré syndrome: clinical profile and management

Sudulagunta

Sodalagunta²,

Sepehrar

et al. 2015

GMS German Medical Science; 13:Doc16

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“…Month wise peaks were seen in May and July; another peak was seen in February. In the first of the Indian reports by Sharma et al, maximum incidence was seen spring and summer, with major clustering seen in spring followed by summer [6]. In contrast, our study reports maximum case clustering in summer months, followed by spring, though overall peaking is comparable in both studies considering the total incidence from February to July.…”

Section: Discussioncontrasting

confidence: 70%

“…Guillain Barre syndrome occurs throughout the year long sporadically with peaks reported at different periods. The same pattern has been reported in the studies by Sharma et al and Kannan et al [6,7]. The present paper is an attempt to comment on the seasonal peaking and gender preponderance of clinically diagnosed patients of Guillain Barre Syndrome in a tertiary institute serving as a referring base for a major region of North India.…”

Section: Introductionsupporting

confidence: 84%

Seasonal, Age & Gender Variation of Guillain Barre Syndrome in a Tertiary Referral Center in India

Sharma¹,

Sood²,

Sharma³

2013

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Background: Seasonal variation & gender preponderance have not been adequately studied in Guillain Barre Syndrome (GBS). University of Health Sciences, Rohtak is the tertiary referral facility for a large part of North West India. We conducted a prospective study to investigate differences in GBS incidence between males and females & across different seasons of the year. Methods: 65 clinically diagnosed GBS patients, aged 5-70 years, referred for nerve conduction, F-wave & EMG studies for 3 years. Results: 64.61% were males while 35.38% were females. Maximum patients were in the age group 5-20 years (46.15%). The highest incidence of GBS (41.53%) were seen in the summer months; 19 (29.23%) in the spring season, 11 (16.92%) in winter season and 8 (12.30%) in rainy season. 5 patients had diarrhoea while 12 patients had flu like syndrome 1-2 weeks before the onset of GBS. Conclusion: The peak seasonal clustering noted by us in the summer months was consistent significantly with other Asian studies. The age and sex distribution of GBS in our series, which showed children & minor preponderance with peak incidence in 5-20 years age followed by another in the age group 21-40 years, is different from most studies which report a second peak after 50 years of age.

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“…Campylobacter jejuni (C. jejuni), which is one of the leading factors associated with the development of GBS, was significantly associated with the development of GBS in all seven studies that studied this association [33][34][35][36][37]. Pneumococcal vaccine, yellow fever and human papillomavirus (HPV) in girls were other vaccines reported in the studies; none were associated with the occurrence of GBS [38][39][40][41].…”

Section: Resultsmentioning

confidence: 99%

Systematic review of factors associated with the development of Guillain–Barré syndrome 2007–2017: what has changed?

Wachira

Peixoto

Oliveira

2018

Tropical Med Int Health

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Objective The objective of this study was to describe the factors associated with the development of Guillain–Barré syndrome, both infectious and non‐infectious, during and after the A(H1N1) influenza pandemic in 2009 and the recent Zika virus epidemic in the Americas. Method Systematic review of literature on factors associated with the development of the Guillain–Barré syndrome published between 2007 and 2017 listed in EBSCO, MEDLINE and LILACS databases. The quality of the studies was evaluated using the Newcastle Ottawa Scale. Results Thirty‐four articles met inclusion criteria and were selected for analysis. Their quality was considered good in relation to most of the items evaluated. Many aetiological agents had the results of association with Guillain–Barré syndrome, among them Campylobacter jejuni, influenza vaccine – both pandemic and seasonal vaccines, respiratory infection, gastrointestinal infection among others. The aetiological agents found are, in most part, the same reported prior to the study period. The association with surgeries, chikungunya virus (CHIKV), Zika virus and quadrivalent human papillomavirus vaccine stand out as new aetiological agents in the list of the various possible agents that trigger Guillain–Barré syndrome reported in the study period. There were no Brazilian studies identified during this period. Conclusions The results of the review reaffirmed C. jejuni as the major trigger of GBS, whereas the association of influenza vaccines and GBS is less clear; Zika virus infection in association with GBS was found in only one study.

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Campylobacter jejuni infection in Guillain-Barré syndrome: A prospective case control study in a tertiary care hospital

Abstract: Preceding C. jejuni infection is common among GBS patients and is often associated with the axonal variety of GBS. Axonal variety of GBS generally presents in a younger age group as compared to AIDP.

Cited by 19 publications

References 16 publications

Guillain-Barré syndrome: clinical profile and management

Guillain-Barré syndrome: clinical profile and management

Seasonal, Age & Gender Variation of Guillain Barre Syndrome in a Tertiary Referral Center in India

Systematic review of factors associated with the development of Guillain–Barré syndrome 2007–2017: what has changed?

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Campylobacter jejuni infection in Guillain-Barré syndrome: A prospective case control study in a tertiary care hospital

Abstract: Preceding C. jejuni infection is common among GBS patients and is often associated with the axonal variety of GBS. Axonal variety of GBS generally presents in a younger age group as compared to AIDP.

Cited by 19 publications

References 16 publications

Guillain-Barré syndrome: clinical profile and management

Guillain-Barré syndrome: clinical profile and management

Seasonal, Age &amp; Gender Variation of Guillain Barre Syndrome in a Tertiary Referral Center in India

Systematic review of factors associated with the development of Guillain–Barré syndrome 2007–2017: what has changed?

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Seasonal, Age & Gender Variation of Guillain Barre Syndrome in a Tertiary Referral Center in India