Campylobacter Pylori and Recurrence of Duodenal Ulcers— A 12-Month Follow-Up Study

Coghlan, J G; Humphries, H.; Dooley, Cornelius P.; Keane, C. T.; Gilligan, D. Rourke; McKenna, Daniel; Sweeney, E. C.; OʼMorain, C

doi:10.1016/s0140-6736(87)91545-5

Cited by 489 publications

(161 citation statements)

References 11 publications

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“…Helicobacter pylori is a polyflagellated spiral gramnegative bacterium and the main etiologic agent of duodenal ulcer (DU) (Coghlan et al 1987, Marshall et al 1988) and chronic gastritis. It is also associated with the development of MALT lymphoma (Wotherspoon et al 1993, Zucca et al 1998) and carcinoma of the stomach (Uemura et al 2001, Passaro et al 2002.…”

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confidence: 99%

Prevalence of cagA and vacA genes in isolates from patients with Helicobacter pylori-associated gastroduodenal diseases in Recife, Pernambuco, Brazil

Brito

Silva

Jucá

et al. 2003

Mem. Inst. Oswaldo Cruz

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confidence: 99%

Prevalence of cagA and vacA genes in isolates from patients with Helicobacter pylori-associated gastroduodenal diseases in Recife, Pernambuco, Brazil

Brito

Silva

Jucá

et al. 2003

Mem. Inst. Oswaldo Cruz

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“…Understanding the epidemiology of H. pylori is an essential step for the development of public health measures due to its association with gastro duodenal diseases (Shiotani et al 2000). The imbalance between the bacterium aggressive factors and the host defence mechanisms may lead to duodenal ulcers, chronic gastritis and stomach cancer (Coghlan et al 1987;Graham & Yamaoka 1998;Passaro et al 2002). The risk of H. pylori infection is high in developing countries (Al-Moagel et al 1990) while the prevalence of H. pylori in developed countries is low due to better industrialization, public health measures/ education and living conditions (Bardhan 1997;Percival & Thomas 2009).…”

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confidence: 99%

PCR assay targeting virulence genes of Helicobacter pylori isolated from drinking water and clinical samples in Lahore metropolitan, Pakistan

Samra

Javaid

Ghafoor

et al. 2011

Journal of Water and Health

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Helicobacter pylorus is considered for chronic gastritis, gastric ulcers and adenocarcinoma and its high infection rate is observed in overcrowded and lower socioeconomic groups in developing countries. This study was designed to identify the role of drinking water in the transmission and prevalence of H. pylori (HP). Selective HP medium was developed for enrichment and presumptive identification of H. pylori by urease, catalase and species specific 16S rRNA tests. The virulence genes (vacA 's' and 'm' regions and cagA) of H. pylori in 90 out of 225 H. pylori positive drinking water samples were present (40%). Ten out of 18 biopsies (55.55%) and 15 out of 50 vomiting fluids of gastric disease patients (30%) were also positive for virulence genes. Anti-H. pylori antibodies were also detected in 31 out of 50 patients' sera. The presence of virulence genes was also directly confirmed by hybridization studies using non-radioactive DNA probes of 16S rRNA, vacA and cagA genes. The presence of H. pylori in water is due to poor sanitary conditions, improper waste disposal and lack of public health education. PCR-based analysis and colony hybridization can be used for detection of H. pylori in clinical and environmental samples.

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“…The recurrence rate of duodenal ulcer was reported from 50% to 80% within one year [1][2][3] . Although Helicobacter pylori (H pylori) colonization has been considered as the most important factor related to the recurrence of duodenal ulcer, and eradication of H pylori has been proved to greatly reduce the recurrence rate [4][5][6][7][8][9][10] . Except for H pylori, there might be other factors contributing to the ulcer recurrence.…”

Section: Introductionmentioning

confidence: 99%

Deformity of duodenal bulb, gastric metaplasia of duodenal regenerating mucosa and recurrence of duodenal ulcer: A correlated study

Chang

Pan

Lien³

et al. 2005

WJG

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AIM:To investigate the correlation among the presence and degree of gastric metaplasia of duodenal regenerating mucosa, the deformity of bulb and the recurrence of duodenal ulcer. METHODS:A total of 99 patients with duodenal ulcer were treated with H 2 -antagonist with or without antimicrobial therapy. All patients received follow-up endoscopic examinations 6 wk after treatment. When the ulcer(s) were noted to be healed, two biopsies were taken from the ulcer scar for histological study of gastric metaplasia, and 4 biopsies were taken from antrum for Helicobacter pylori (H pylori) study. Out of these cases, 44 received further follow-up endoscopic examinations after 3, 6 and 12 mo respectively for studying the recurrence rate of duodenal ulcers. The correlation among ulcer recurrence, degree of gastric metaplasia of regenerating mucosa, bulbar deformity, and colonization of H pylori in the stomach was then studied. RESULTS:The results showed that there was a strong correlation between the deformity of duodenal bulb and the degree of gastric metaplasia of regenerating duodenal mucosa. The recurrence rate of duodenal ulcer had a significant difference between patients with and without H pylori colonization in the stomach (P<0.001). The greater the degree of gastric metaplasia of duodenal regenerating mucosa, the higher the recurrence rate of duodenal ulcer (P = 0.021). The more deformed the duodenal bulb, the higher the incidence of recurrence of duodenal ulcer (P = 0.03). CONCLUSION:There is a correlation among deformity of duodenal bulb, gastric metaplasia of duodenal regenerating mucosa and recurrence of duodenal ulcer. A more severely deformed duodenal bulb is closely related to a greater extent of gastric metaplasia. Both factors contribute to the recurrence of duodenal ulcer.

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Campylobacter Pylori and Recurrence of Duodenal Ulcers— A 12-Month Follow-Up Study

Cited by 489 publications

References 11 publications

Prevalence of cagA and vacA genes in isolates from patients with Helicobacter pylori-associated gastroduodenal diseases in Recife, Pernambuco, Brazil

Prevalence of cagA and vacA genes in isolates from patients with Helicobacter pylori-associated gastroduodenal diseases in Recife, Pernambuco, Brazil

PCR assay targeting virulence genes of Helicobacter pylori isolated from drinking water and clinical samples in Lahore metropolitan, Pakistan

Deformity of duodenal bulb, gastric metaplasia of duodenal regenerating mucosa and recurrence of duodenal ulcer: A correlated study

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