Campylobacteriosis in man: Pathogenic mechanisms and review of 91 bloodstream infections

Guerrant, Richard L.; Lahita, Robert G.; Winn, Washington C.; Roberts, Richard B.

doi:10.1016/0002-9343(78)90845-8

Cited by 238 publications

(93 citation statements)

References 60 publications

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“…results of previous studies (Guerrant et al, 1978;Ruiz-Palacios et al, 1983 ;Johnson and Lior, 1984) and further supports the general consensus on the absence of ST-like enterotoxin production by C. jejuni. Similarly, other studies showed that CT from C. jejuni did not induce fluid secretion in rat ligated ileal loops (Klipstein et al, 1985).…”

Section: Discussionsupporting

confidence: 86%

In-vitro and in-vivo studies of a cytotoxin from Campylobacter jejuni

Pang.¹,

Wong²,

Puthucheary³

et al. 1987

Journal of Medical Microbiology

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Summary. Studies were performed on a cytotoxin (CT) from human strains of Campylobacter jejuni isolated in Malaysia. CT was detected by cytopathic effect (CPE) on HeLa cells at titres from 8 to 32, in culture filtrates from 14 (48%) of 29 human isolates. The CPE correlated well with a quantitative 'lcr-release assay where a specific release of 5 4 6 8 % was noted. CT production was lost after 5-7 subcultures. CT activity was also detected in 5 (26%) of 19 faecal filtrates from which CTproducing isolates were subsequently obtained. The mol. wt of CT was estimated by Sephadex G-50 chromatography to be > 30 000. In a suckling-mouse assay, CT consistently failed to demonstrate fluid accumulation after intragastric inoculation of culture filtrate. The Removable Intestinal Tie Adult Rabbit Diarrhoea (RITARD) assay was also used. Rabbits given CT-producing strains of C. jejuni developed bacteraemia and severe watery mucus-containing diarrhoea for the duration of the experiment with death of some animals. Rabbits given CT non-producing strains had less severe disease and none died. Rabbits given partially-purified CT had diarrhoea for 3 days but none died.

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Section: Discussionsupporting

confidence: 86%

In-vitro and in-vivo studies of a cytotoxin from Campylobacter jejuni

Pang.¹,

Wong²,

Puthucheary³

et al. 1987

Journal of Medical Microbiology

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“…The last major review of campylobacter bacteraemia was published in the USA in 1978 before it was widely known that campylobacter enteritis was a common infection [1]. In that review, reports of bacteraemia due to Campylobacter fetus outnumbered those due to C. jejuni (C. fetus subsp.…”

Section: Introductionmentioning

confidence: 99%

Campylobacter bacteraemia in England and Wales, 1981-91

et al. 1993

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SUMMARYRoutine surveillance of infection in England and Wales detected 394 cases of campylobacter bacteraemia in 11 years. This represented an average incidence of 1-5 per 1000 intestinal campylobacter infections, with a range of 03/1000 in children aged 1-4 years to 5 9/1000 in patients aged 65 years or more. Definitive identification of 257 isolates showed that 89% were Campylobacter jejuni or C. coli; other species were C. fetus (8-6%), C. lari (0-8%), C. upsaliensis (0-8%), Helicobacter (Campylobacter) fennelliae (0-8 %), and Helicobacter (Campylobacter) cinaedi (0 4%). Most (71 %) of the C. jejuni/C. coli bacteraemias were in patients with acute enteritis. Of the patients with C. fetus bacteraemia only 27 % had diarrhoea; they were older than patients with C. jejuni or C. coli bacteraemia (54 1 v. 45*9 years) and proportionally more of them were male (M:F ratio 2 7: 1 v. 19: 1); 41 % had endovascular pathology or cellulitis. There was a higher proportion of C. jejuni serogroup 0 4 (Penner) and 0 18 strains among blood than faecal isolates, which suggests that they were unusually serum resistant and/or invasive.

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“…Campylobacter fetus is an opportunistic bacterial pathogen causing infectious abortion and infertility in ungulates (27) and systemic diseases in immunocompromised humans (5,9,17,20). There are two serotypes of C. fetus (A and B), a property based on LPS characteristics (33).…”

mentioning

confidence: 99%

Reattachment of surface array proteins to Campylobacter fetus cells

et al. 1992

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Campylobacterfetus strains may be of serotype A or B, a property associated with lipopolysaccharide (LPS) structure. Wild-type C. fetus strains contain surface array proteins (S-layer proteins) that may be extracted in water and that are critical for virulence. To explore the relationship of S-layer proteins to other surface components, we reattached S-layer proteins onto S-template cells generated by spontaneous mutation or by serial extractions of S' cells with water. Crystalline surface layers have been observed as the outermost component of the bacterial cell envelopes in numerous gram-positive and gram-negative species (38) and are composed of protein subunits assembled over the cell surface into two-dimensional arrays with hexagonal (p6), square (p4), or oblique (p2) symmetry (36). For the majority of bacteria, the surface layer is formed from a single species of protein, known as a surface array protein (S-layer protein), which is acidic and generally hydrophobic (36,38). In gram-negative bacteria, the constituent subunits of most S-layers interact with each other and with the underlying outer membrane components (3,35,37,40), such as outer membrane proteins in an Acinetobacter sp. (41), lipid-lipopolysaccharide (LPS) in Spirillum serpens (11), and LPS in Aeromonas salmonicida (2, 22), and many S-layers require divalent cations for assembly (10,37,40).

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Campylobacteriosis in man: Pathogenic mechanisms and review of 91 bloodstream infections

Cited by 238 publications

References 60 publications

In-vitro and in-vivo studies of a cytotoxin from Campylobacter jejuni

In-vitro and in-vivo studies of a cytotoxin from Campylobacter jejuni

Campylobacter bacteraemia in England and Wales, 1981-91

Reattachment of surface array proteins to Campylobacter fetus cells

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