Can a Strychnos species be used as antiulcer agent? Ulcer healing action from alkaloid fraction of Strychnos pseudoquina St. Hil. (Loganiaceae)

Abstract

The expressive gastric healing effect by increasing cellular proliferation together with expression of SOD activity and antibacterial action against Helicobacter pylori confirm the efficacy of this species in heal gastric mucosa and these results are a important contribution to the knowledge of a crude drug presents at the Brazilian Official Pharmacopoeia since 1929.

Antimicrobial activity of natural products against Helicobacter pylori: a review

“… Myrtaceae Fruit Acetone Extract In vitro [ 34 ] Strychnos pseudoquina A. St. Hil. Loganiaceae Leaves Methanol extract/alkaloid enriched fraction In vitro and in vivo [ 35 ] Bixa orellana L. Bixaceae Seed Ethanol Extract In vitro [ 4 ] Chamomilla recutita L. Asteraceae Inflorescence Ethanol Extract In vitro [ 4 ] Ilex paraguariensis A. St.-Hil. Aquifoliaceae Green leaves Ethanol Extract In vitro [ 4 ] Ilex paraguariensis A. St.-Hil.…”

Antiulcer activities of the hydroethanolic extract of Sedum dendroideum Moc et Sessé ex DC. (balsam)

“…This model most closely simulates human gastric ulceration because acetic acid penetrates and directly affects the gastric mucosa, submucosa, and the muscle layer (Bonamin et al, 2011). ESD and cimetidine achieved a rate of cure of chronic ulcers of 92.99% and 77.16%, respectively, which was significantly higher than that of the negative controls (Table 4).…”

Gastroprotective and antioxidant potentials of ethanolic stem bark extract of Margaritaria discoidea (Euphorbiaceae) in rats

“…It acts by transforming ROS into less reactive hydrogen peroxide and protects the cells from damage through the removal of the excess radicals. The SOD activity level represents the intracellular antioxidant ability of the cell (Bonamin et al, 2011). Catalase controls the accumulation of ROS generated through numerous metabolic processes such as the breakdown of ethanol in the stomach.…”