Can ABCF2 protein expression predict the prognosis of uterine cancer?

Nishimura, Sadako; Tsuda, Hiroshi; Miyagi, Yasunari; Hirasawa, Akira; Suzuki, Atsushi; Kataoka, Fumio; Nomura, Hiroyuki; Chiyoda, Tatsuyuki; Banno, Kouji; Fujii, Takuma; Susumu, Nobuyuki; Aoki, Daisuke

doi:10.1038/sj.bjc.6604734

Cited by 9 publications

(5 citation statements)

References 22 publications

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“…Previous studies have shown that ABCF2 expression correlates with cisplatin resistance in human bladder cancer T24 cell lines and clear cell ovarian cancer . ABCF2 was also indicated to be a potential marker for clear cell adenocarcinomas of the ovary and the uterine corpus . However, the precise molecular mechanism by which ABCF2 mediates cisplatin resistance is not clear.…”

Section: Discussionmentioning

confidence: 99%

“…22 ABCF2 was also indicated to be a potential marker for clear cell adenocarcinomas of the ovary and the uterine corpus. 23,33 However, the precise molecular mechanism by which ABCF2 mediates cisplatin resistance is not clear. Our study provides evidence for a direct role of ABCF2 in mediating cisplatin resistance, since ABCF2 overexpression rendered A2780 cells more resistant to cisplatin and ABCF2 knockdown rendered resistant A2780 cells more sensitive to cisplatin ( Figure 6).…”

Section: Discussionmentioning

confidence: 99%

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ABCF2, an Nrf2 target gene, contributes to cisplatin resistance in ovarian cancer cells

Bao

Dodson

et al. 2017

Molecular Carcinogenesis

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Previously, we have demonstrated that NRF2 plays a key role in mediating cisplatin resistance in ovarian cancer. To further explore the mechanism underlying NRF2-dependent cisplatin resistance, we stably overexpressed or knocked down NRF2 in parental and cisplatin-resistant human ovarian cancer cells, respectively. These two pairs of stable cell lines were then subjected to microarray analysis, where we identified 18 putative NRF2 target genes. Among these genes, ABCF2, a cytosolic member of the ABC superfamily of transporters, has previously been reported to contribute to chemoresistance in clear cell ovarian cancer. A detailed analysis on ABCF2 revealed a functional antioxidant response element (ARE) in its promoter region, establishing ABCF2 as an NRF2 target gene. Next, we investigated the contribution of ABCF2 in NRF2-mediated cisplatin resistance using our stable ovarian cancer cell lines. The NRF2-overexpressing cell line, containing high levels of ABCF2, was more resistant to cisplatin-induced apoptosis compared to its control cell line; whereas the NRF2 knockdown cell line with low levels of ABCF2, was more sensitive to cisplatin treatment than its control cell line. Furthermore, transient overexpression of ABCF2 in the parental cells decreased apoptosis and increased cell viability following cisplatin treatment. Conversely, knockdown of ABCF2 using specific siRNA notably increased apoptosis and decreased cell viability in cisplatin-resistant cells treated with cisplatin. This data indicates that the novel NRF2 target gene, ABCF2, plays a critical role in cisplatin resistance in ovarian cancer, and that targeting ABCF2 may be a new strategy to improve chemotherapeutic efficiency.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

ABCF2, an Nrf2 target gene, contributes to cisplatin resistance in ovarian cancer cells

Bao

Dodson

et al. 2017

Molecular Carcinogenesis

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“…Among three ABCF protein members, the expression level of ABCF2 is significantly higher in ovarian and cervical cancer cells but not in uterine endometrial cancer cells, thereby ABCF2 may serve as a prognostic indicator for ovarian and uterine cervical cancers 158,159 166 .…”

Section: Abcf Subfamilymentioning

confidence: 99%

“…Hence, ABCF2 was initially thought to be linked to drug resistance 157 . Among three ABCF protein members, the expression level of ABCF2 is significantly higher in ovarian and cervical cancer cells but not in uterine endometrial cancer cells, thereby ABCF2 may serve as a prognostic indicator for ovarian and uterine cervical cancers 158,159 . Additionally, ABCF2 possibly plays roles in mediating cisplatin‐induced drug resistance, evidenced by enhanced ABCF2 gene level in cisplatin‐resistant bladder cells and clear cell ovarian cancer 160–162 .…”

Section: Abc Transporter Subfamilies: Structure Function and The Rela...mentioning

confidence: 99%

ATP‐binding cassette (ABC) transporters in cancer: A review of recent updates

Wang

Yang

et al. 2021

J Evidence Based Medicine

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The ATP-binding cassette (ABC) transporter superfamily is one of the largest membrane protein families existing in wide spectrum of organisms from prokaryotes to human. ABC transporters are also known as efflux pumps because they mediate the cross-membrane transportation of various endo-and xenobiotic molecules energized by ATP hydrolysis. Therefore, ABC transporters have been considered closely to multidrug resistance (MDR) in cancer, where the efflux of structurally distinct chemotherapeutic drugs causes reduced itherapeutic efficacy. Besides, ABC transporters also play other critical biological roles in cancer such as signal transduction. During the past decades, extensive efforts have been made in understanding the structure-function relationship, transportation profile of ABC transporters, as well as the possibility to overcome MDR via targeting these transporters. In this review, we discuss the most recent knowledge regarding ABC transporters and cancer drug resistance in order to provide insights for the development of more effective therapies. INTRODUCTIONSince the first discovery of the membrane transport protein Pglycoprotein (P-gp) or ATP-binding cassette (ABC) transporter B1 (ABCB1) in resistant cancer cells in the mid-1970s, more and more members in ABC transporter superfamily such as ABCG2 (breast cancer resistance protein, BCRP) and MRPs (multidrug resistance proteins) were discovered and characterized, especially the structurefunction relationship and their roles in tumorigenesis 1 (Figure 1). ABC transporter proteins are best known for mediating multidrug resistance (MDR) in cancer and lead to failure of chemotherapy. Besides, studies also revealed their critical roles in cancer as more than efflux pumps. 2,3 ABC transporter superfamily is composed of 7 subfamilies, namely ABCA to ABCG In human the ABC transporter superfamily is divided into least 48 members with different functions.

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“…TKIs in vitro [60][61][62] . Porém, apesar desse gene ser descrito com expressão alterada em diversos tipos de tumores, como câncer de mama 63 , câncer de útero 64 , cânceres de ovário 65,66 e câncer colo retal 67…”

Section: Mecanismos De Resistência Ao Tratamentounclassified

Avaliação da resposta molecular e da expressão dos genes ABCF2, ALOX15B, PAWR, ncFOXO3A, ncMYLIP e ncSLC44A2 em pacientes com leucemia mielóide crônica em uso de inibidores de tirosina quinase de segunda geração

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Can ABCF2 protein expression predict the prognosis of uterine cancer?

Cited by 9 publications

References 22 publications

ABCF2, an Nrf2 target gene, contributes to cisplatin resistance in ovarian cancer cells

ABCF2, an Nrf2 target gene, contributes to cisplatin resistance in ovarian cancer cells

ATP‐binding cassette (ABC) transporters in cancer: A review of recent updates

Avaliação da resposta molecular e da expressão dos genes ABCF2, ALOX15B, PAWR, ncFOXO3A, ncMYLIP e ncSLC44A2 em pacientes com leucemia mielóide crônica em uso de inibidores de tirosina quinase de segunda geração

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