Can aquaporins be used as diagnostic and prognostic markers for uterine smooth muscle tumours?

Alabalık, Ulaş; Türkçü, Gül; Keleş, Ayşe Nur; İbiloğlu, İbrahim; Özler, Ali; Urakçı, Zuhat; Büyükbayram, Hüseyin

doi:10.1080/13102818.2016.1240018

Cited by 4 publications

(1 citation statement)

References 38 publications

(38 reference statements)

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“…Staining intensity of cells: if staining was not present, the score was 0; in the presence of weak staining, the score was 1; moderate staining was determined as 2; and strong staining was determined as 3. If there was no staining in the total score, it was considered negative, 1 and 2 weakly positive, 3 and 4 moderately positive, and 5-7 strong positive [12].…”

Section: Immunohistochemical Studiesmentioning

confidence: 99%

Investigation of ZIP4, ZO-1, and CLAUDIN-1 expression in thyroid tumours by immunohistochemistry and real-time polymerase chain reaction methods

Nacir,

İbiloğlu,

Alabalık

2023

pjp

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Thyroid neoplasms are the most common endocrine malignancies. ZIP4 is an intramembranous zinc trans membrane protein. Zinc plays a central role in the activation of transcription factors, and zinc transporters. This affects tumour migration, invasion, and cell proliferation. ZO-1 and Claudin-1 are important tight junction proteins whose amounts increase and decrease in various cancers. In this study, we aimed to investigate the expression of ZIP4, ZO-1, and Claudin-1 in thyroid tumours and the relationship of this expression with tumour types and prognostic parameters. ZIP4, ZO-1, and Claudin-1 were studied in all cases by immunohistochemical and Real-Time PCR methods. ZIP4 and Claudin-1 tended to be expressed more in cases with tumours, while ZO-1 in cases with and without tumours. Expression of ZIP4 and Claudin-1 by real-time polymerase chain reaction showed a significant difference between histological subtypes, and this difference was not observed with ZO-1. It was observed that the presence of metastasis increased with the expression of ZIP4 and Claudin-1, and there was no significant change with ZO-1. We think that Claudin-1 and ZIP4 expression can be used as an important marker in terms of showing poor prognosis and susceptibility to metastasis in thyroid tumours, and in developing targeted therapy.

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Section: Immunohistochemical Studiesmentioning

confidence: 99%

Investigation of ZIP4, ZO-1, and CLAUDIN-1 expression in thyroid tumours by immunohistochemistry and real-time polymerase chain reaction methods

Nacir,

İbiloğlu,

Alabalık

2023

pjp

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Aquaporins in cancer development: opportunities for bioinorganic chemistry to contribute novel chemical probes and therapeutic agents

et al. 2018

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Aquaporins (AQPs) are membrane proteins allowing permeation of water, glycerol & hydrogen peroxide across biomembranes, and playing an important role in water homeostasis in different organs, exocrine gland secretion, urine concentration, skin moisturization, fat metabolism and neural signal transduction. Notably, a large number of studies showed that AQPs are closely associated with cancer biological functions and expressed in more than 20 human cancer cell types. Furthermore, AQP expression is positively correlated with tumour types, grades, proliferation, migration, angiogenesis, as well as tumour-associated oedema, rendering these membrane channels attractive as both diagnostic and therapeutic targets in cancer. Recent developments in the field of AQPs modulation have identified coordination metal-based complexes as potent and selective inhibitors of aquaglyceroporins, opening new avenues in the application of inorganic compounds in medicine and chemical biology. The present review is aimed at providing an overview on AQP structure and function, mainly in relation to cancer. In this context, the exploration of coordination metal compounds as possible inhibitors of aquaporins may open the way to novel chemical approaches to study AQP roles in tumour growth and potentially to new drug families. Thus, we describe recent results in the field and reflect upon the potential of inorganic chemistry in providing compounds to modulate the activity of "elusive" membrane targets as the aquaporins.

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Can EBP50 and Merlin be used as diagnostic and prognostic markers for uterine smooth muscle tumors?

Alabalik,

Keleş,

Gündüz

et al. 2024

Biotechnology & Biotechnological Equipment

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Can aquaporins be used as diagnostic and prognostic markers for uterine smooth muscle tumours?

Cited by 4 publications

References 38 publications

Investigation of ZIP4, ZO-1, and CLAUDIN-1 expression in thyroid tumours by immunohistochemistry and real-time polymerase chain reaction methods

Investigation of ZIP4, ZO-1, and CLAUDIN-1 expression in thyroid tumours by immunohistochemistry and real-time polymerase chain reaction methods

Aquaporins in cancer development: opportunities for bioinorganic chemistry to contribute novel chemical probes and therapeutic agents

Can EBP50 and Merlin be used as diagnostic and prognostic markers for uterine smooth muscle tumors?

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