Can bioadhesive nanoparticles allow for more effective particle uptake from the small intestine?

Reineke, Joshua; Cho, Daniel; Dingle, Yu‐Ting L.; Cheifetz, Peter; Laulicht, Bryan; Lavin, Danya M.; Furtado, Stacia; Mathiowitz, Edith

doi:10.1016/j.jconrel.2013.05.043

Cited by 51 publications

(42 citation statements)

References 36 publications

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“…For example, these particles are hydrophobic in nature, so there may be a hydrophobic driving force "pushing" particles toward the gut walls and away from the aqueous lumen. Regardless of the specific mechanisms involved in mucus transport, we feel that it occurs and the fact that orally fed particles (in absence of effects from the artificial isolated loop administration) also experience high uptake is strong evidence of this transport (51).…”

Section: Discussionmentioning

confidence: 90%

Unique insights into the intestinal absorption, transit, and subsequent biodistribution of polymer-derived microspheres

Reineke

Cho

Dingle

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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Polymeric microspheres (MSs) have received attention for their potential to improve the delivery of drugs with poor oral bioavailability. Although MSs can be absorbed into the absorptive epithelium of the small intestine, little is known about the physiologic mechanisms that are responsible for their cellular trafficking. In these experiments, nonbiodegradable polystyrene MSs (diameter range: 500 nm to 5 μm) were delivered locally to the jejunum or ileum or by oral administration to young male rats. Following administration, MSs were taken up rapidly (≤5 min) by the small intestine and were detected by transmission electron microscopy and confocal laser scanning microscopy. Gel permeation chromatography confirmed that polymer was present in all tissue samples, including the brain. These results confirm that MSs (diameter range: 500 nm to 5 μm) were absorbed by the small intestine and distributed throughout the rat. After delivering MSs to the jejunum or ileum, high concentrations of polystyrene were detected in the liver, kidneys, and lungs. The pharmacologic inhibitors chlorpromazine, phorbol 12-myristate 13-acetate, and cytochalasin D caused a reduction in the total number of MSs absorbed in the jejunum and ileum, demonstrating that nonphagocytic processes (including endocytosis) direct the uptake of MSs in the small intestine. These results challenge the convention that phagocytic cells such as the microfold cells solely facilitate MS absorption in the small intestine.oral delivery | uptake mechanism B eginning in the 1960s, several groups (1-7) demonstrated that the small intestine could absorb microparticles with a diameter >1 μm, challenging dogma that the small intestine could only absorb small macromolecules. After this discovery, researchers began engineering microspheres (MSs) to deliver drugs with poor water solubility (8-10), poor gastrointestinal permeability (11), or poor oral bioavailability (8,9,(12)(13)(14)(15) to the small intestine. MS-based oral drug delivery systems (ODDSs) can be made from biodegradable polymers (12,(16)(17)(18), nondegradable polymers (19-21), and polysaccharides (22, 23) and can be engineered to carry polypeptides (18,24,25) and other molecules (26, 27). The motivation for using microparticulate-based ODDSs is to improve the oral bioavailability of drugs by enhancing their delivery and transit through the absorptive epithelium of the small intestine. This work may ultimately enable patients to take medications orally instead of relying on daily or weekly injections or other, less convenient routes of administration (28).More than five decades after Sanders and Ashworth discovered that the small intestine can engulf large particles (1), little is known today about the cellular mechanisms or physiologic pathways that facilitate the absorption, transit, and biodistribution of microparticles that are delivered to the small intestine. Nonetheless, the diverse physiology and multitude of cell types in the small intestine likely play a central role in these processes. The absorp...

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Section: Discussionmentioning

confidence: 90%

Unique insights into the intestinal absorption, transit, and subsequent biodistribution of polymer-derived microspheres

Reineke

Cho

Dingle

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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“…The mucoadhesive polymers prolong retention time of the particles in the mucus by steric or adhesive interactions. Coating of nonbioadhesive nanospheres with poly(butadiene-maleic anhydrideco-L-DOPA) increased the particle uptake by 10-fold in the small intestine [133]. Conjugation of immunostimulatory ligands to bioadhesive polymers should induce longer-lasting mucosal and systemic immune responses against entrapped antigens.…”

Section: Polymeric Particle-based Oral Deliverymentioning

confidence: 99%

Current and New Approaches for Mucosal Vaccine Delivery

Rhee

2020

Mucosal Vaccines

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“…19 Essentially, there are two theories explaining the consolidation step: the diffusion theory and the dehydration theory. 20 According to diffusion theory, the mucoadhesive molecules and the glycoproteins of the mucus mutually interact by means of interpenetration of their chains and the building of secondary bonds. 21 The mucoadhesive device has features whichfavor both chemical and mechanical interactions.…”

Section: Figure1: Mechanism Of Mucoadhesionmentioning

confidence: 99%

An Overview on Natural Polymer Based Mucoadhesive Buccal Films for Controlled Drug Delivery

Khade¹,

Sabale²,

Gadge³

et al. 2019

IRJPS

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Mucoadhesion is the process where polymers attach to biological substrate or a syn to mucus or an epithelial surface. When the biological substrate is attached to a mucosal layer then this phenomenon is known as mucoadhesion. The substrate possessing bioadhesive polymer can help in drug delivery for a prolonged period of time at a specific delivery site. Mucoadhesive polymers are used to improve drug delivery by enhancing the dosage form's contact time and residence time with the mucous membrane mucoadhesion and some factors which have the ability to affect the mucoadhesive properties of a polymer. Both natural and synthetic polymers are used for the preparation of mucoadhesive buccal which can be used in mucoadhesive buccal This review is an effort to summarize the work done till date and to show the future pathway of mucoadhesive buccal films preparation using natural polymer.

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Can bioadhesive nanoparticles allow for more effective particle uptake from the small intestine?

Cited by 51 publications

References 36 publications

Unique insights into the intestinal absorption, transit, and subsequent biodistribution of polymer-derived microspheres

Unique insights into the intestinal absorption, transit, and subsequent biodistribution of polymer-derived microspheres

Current and New Approaches for Mucosal Vaccine Delivery

An Overview on Natural Polymer Based Mucoadhesive Buccal Films for Controlled Drug Delivery

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