Can calcitonin nasal spray reduce the risk of recurrence of central giant cell granuloma of the jaws? A double-blind clinical trial

Fardisi, Sorena; Zamiri, Bardia; Amanpour, Sara; Karagah, Tuba

doi:10.1016/j.ijom.2016.02.016

Cited by 16 publications

(8 citation statements)

References 20 publications

(34 reference statements)

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“…Subcutaneous or intranasal calcitonin administration has also been proposed as a treatment with or without surgery [15]. Its usage was studied in a randomized, double-blind, and placebo-controlled trial, in which the researchers reveal a significantly lower recurrence rate when treating GCG by aggressive surgical management followed by intranasal calcitonin [16]. A final therapeutic strategy uses denosumab targeted therapy without surgical treatment.…”

Section: Commentsmentioning

confidence: 99%

Giant-cell granuloma: 2 case reports

Abdelqader

Roche

Manfredi

et al. 2018

J Oral Med Oral Surg

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Introduction: Giant-cell granuloma (GCG) is a benign tumor occurring almost exclusively in the jaws. These lesions remain rare but can sometime have an aggressive behavior. In this article, we will describe and follow two cases of GCG. Observations: The first case is a referred female patient, who presents a mandibular swelling. Its clinical and radiological aspects lead us to do a biopsy, with a histological result of GCG. The second case is a patient with a terminal kidney failure, referred for a buccal swelling in the upper left jaw. The cone-beam computed tomography X-ray shows a compartmentalized lesion with blurry limits. An excisional biopsy is performed and the histological diagnosis is a GCG. Discussion: Although the first patient suffers from no systemic disease, the second one presents a terminal kidney failure resulting in a chronic hyperparathyroidism. Hyperparathyroidism can activate osteoclastic resorption and create bone lesions such as brown tumors. Conclusion: The slow and asymptomatic growth of these lesions often result in a late diagnosis. It should be kept in mind as a differential diagnosis when dealing with an osteolytic lesion of the jaws with no clear etiology, especially if hyperparathyroidism or kidney failure is associated.

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Section: Commentsmentioning

confidence: 99%

Giant-cell granuloma: 2 case reports

Abdelqader

Roche

Manfredi

et al. 2018

J Oral Med Oral Surg

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“…This is in agreement with Suárez-Roa et al, 2009 (43) and Tabrizi et al, 2012. (44) But, in disagreement with Munzenmayer J et al, 2013 (45) who reported that surgical curettage is not an effective therapy for CGCG in young people who show aggressive signs and symptoms.…”

Section: Discussionmentioning

confidence: 96%

An aggressive central giant cell granuloma of maxilla: Diagnostic dilemma, Precise differential diagnosis and successful traditional surgical approach: A case report

Elmezwghi

Alarabi

Elsagali

et al. 2020

Egyptian Dental Journal

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Central Giant Cell Granuloma (CGCG) is a benign, proliferative, intraosseous and nonodontogenic lesion of unknown etiology accounting for approximately 10% of all benign lesions of the jawbones. Lesion usually occurs in patients younger than 30 years, is more common in females than males, and is more common in mandible than maxilla. The clinical feature of CGCG ranges from a slow growing asymptomatic swelling to a rapidly enlarging aggressive lesion. CGCG of the jaws are histologically benign lesions characterized by the presence of giant cells in the richly vascularized stroma of the spindle cells. Differential diagnosis should be performed with other lesions that have multinucleated giant cells (MGCs). Definitive diagnosis relies on correct interpretation of clinical, radiographical and histopathological data. The treatment of CGCG ranges from curettage to resection. Alternative treatments are worthy of consideration, although surgical excision remains the treatment of choice. The aim of this presented case highlights a diagnostic challenge of an aggressive CGCG arising from the maxilla and to discuss a precise differential diagnosis, as well as the surgical approach and follow up which is decisive for successful conventional surgical treatment with no lesion recurrence.

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“…Complete secondary resection, if possible, is beneficial for patients with recurrence. Pharmacological agents, including calcitonin [9, 10], IFN-α [8], and denosumab [11], are promising alternatives to surgical management. Pharmacological agents have the potential to decrease the recurrence rate, minimizing the morbidity associated with surgery, and even prevent the need for surgical intervention [9, 12, 13].…”

Section: Discussionmentioning

confidence: 99%

Radiotherapy for recurrent central Giant cell granuloma: a case report

Zhang

Wang

et al. 2019

Radiat Oncol

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Background Central giant cell granuloma (CGCG) is a rare, non-neoplastic, benign lesion that exhibits expansive and osteolytic biological behavior. CGCG treatment and management is challenging for clinicians. Case presentation This report presents the treatment and management of recurrent, aggressive CGCG after surgical resection. After informed consent was obtained, the patient underwent radiotherapy. The lesion size was reduced significantly, with no evidence of recurrence or malignant transformation. Conclusions This treatment experience indicates that radiotherapy can be used as a rescue treatment for complicated CGCG involving vital neurovascular structures of the cranial base.

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Can calcitonin nasal spray reduce the risk of recurrence of central giant cell granuloma of the jaws? A double-blind clinical trial

Cited by 16 publications

References 20 publications

Giant-cell granuloma: 2 case reports

Giant-cell granuloma: 2 case reports

An aggressive central giant cell granuloma of maxilla: Diagnostic dilemma, Precise differential diagnosis and successful traditional surgical approach: A case report

Radiotherapy for recurrent central Giant cell granuloma: a case report

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